Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ronald E. Johnston"'
Publikováno v:
STRENGTH AND CONDITIONING JOURNAL. 17:7
Publikováno v:
Toxicology and Applied Pharmacology. 30:90-95
Cadmium administration potentiated the duration of hexobarbital sleep time in the male rat but did not influence the onset time for anesthesia. The threshold dose levels of hexobarbital required for sleep induction determined by extrapolation from th
Autor:
Gertrude B. Elion, Walter E. Tucker, Paulo de Miranda, Alexander W. Macklin, George M. Szczech, Robert J. Szot, Ronald E. Johnston
Publikováno v:
Fundamental and Applied Toxicology. 3:569-572
Topical formulations of acyclovir (ACV) were tested in animals to define potential for tissue irritation and systemic toxicity. Acyclovir ointments (5 and 10% concentrations in polyethylene glycol vehicle) produced no sign of dermal irritation or sys
Autor:
George M. Szczech, Walter E. Tucker, Ronald E. Johnston, Gertrude B. Elion, Paulo de Miranda, Alexander W. Macklin, Robert J. Szot
Publikováno v:
Fundamental and Applied Toxicology. 3:573-578
Acyclovir (ACV), a new antiherpes drug, was evaluated for toxicity in a series of acute and subchronic toxicity tests. Oral LD50 values were greater than 10 000 mg/kg in male ICR mice and greater than 20 000 mg/kg in male Long Evans rats. When ACV wa
Publikováno v:
Biochemical Pharmacology. 24:877-881
Three days after a single cadmium dose (2 mg/kg), the duration of response to subsequently administered hexobarbital or zoxazolamine was potentiated. Duration of sleep was prolonged (225 per cent) in cadmium-treated rats, but the awakening plasma hex
Facilitated avoidance learning and stress-induced corticosterone levels as a function of age in rats
Publikováno v:
Physiologybehavior. 12(2)
Three month and 6 month old rats were trained in a two-way shuttle box active avoidance task. The procedure consisted of giving each rat 60 acquisition trials which were immediately followed by 60 extinction trials. The older animals acquired the con