Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Ronald E Chance"'
Autor:
Ronald E. Chance, James M. Pettee, Allen H. Pekar, Elmer M. Schirmer, Melvin G. Johnson, Bruce H. Frank
Publikováno v:
International Journal of Peptide and Protein Research. 23:506-515
A genetic variant of bovine proinsulin has been isolated using preparative reverse-phase HPLC. The new proinsulin (bovine proinsulin II) differs from the known proinsulin (bovine proinsulin I) by a single amino acid residue at position C-48 in the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906e2e9dbd9559391796e52f1d40f5dd
https://doi.org/10.1111/j.1399-3011.1984.tb02751.x
https://doi.org/10.1111/j.1399-3011.1984.tb02751.x
Autor:
Amy L. Cox, Ronald E. Chance, David S. McClellan, Sharon R. Myers, Mark L. Brader, Allen H. Pekar, David B. Flora, Lynnie A. Irwin, Muppalla Sukumar
Publikováno v:
Nature Biotechnology. 20:800-804
The ability to tailor the release profile of a drug by manipulating its formulation matrix offers important therapeutic advantages. We show here that human insulin can be cocrystallized at preselected ratios with the fully active lipophilically modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8790eb3ca0b2a121ab35819f7e94f75a
https://doi.org/10.1038/nbt722
https://doi.org/10.1038/nbt722
Autor:
Ronald R. Bowsher, Ronald E. Chance, William E. Legan, James R. Woodworth, Renee A. Lynch, Patricia Brown-Augsburger, Paula F. Santa
Publikováno v:
Clinical Chemistry. 45:104-110
Insulin lispro is an insulin analog in which the primary sequence has been altered by the inversion of amino acids B28 and B29. To date, it has not been possible to specifically measure insulin lispro in the presence of endogenous insulin because of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aab26e78f7f86be8e5fe12baba09f735
https://doi.org/10.1093/clinchem/45.1.104
https://doi.org/10.1093/clinchem/45.1.104
Autor:
Richard D. DiMarchi, B. Bradley, Ronald E. Chance, J. Braaten, J. Radziuk, Ronald R. Bowsher, S. Pye, P. Roach, L. Vignati
Publikováno v:
Diabetologia. 41:116-120
[Ne-palmitoyl Lys (B29)] human insulin is a fatty acid-acylated derivative of insulin with extended action compared to unmodified insulin when infused intravenously (i. v.) secondary to its binding to circulating albumin. The duration and activity pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a40e011f0fd670f444971047076cdf8
https://doi.org/10.1007/s001250050876
https://doi.org/10.1007/s001250050876
Autor:
David B. Flora, Mary P. Stickelmeyer, Ronald E. Chance, Bruce H. Frank, Jane P. Richards, Michael Rosario Defelippis
Publikováno v:
Pharmaceutical Research. 15:1434-1441
Purpose. The purpose of the current study was to investigate the effects of two important excipients, zinc and m-cresol, on the self-association properties of a series of monomeric insulin analogs. In this way, the effects on formulation behavior of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2464cf3128097c18cf4896df3d2e27b
https://doi.org/10.1023/a:1011961923870
https://doi.org/10.1023/a:1011961923870
Autor:
Shai N. Gozani, Bruce H. Frank, Qing Xin Hua, Ronald E. Chance, James Arthur Hoffmann, Michael A. Weiss
Publikováno v:
Nature Structural & Molecular Biology. 2:129-138
We have determined the structure of a metastable disulphide isomer of human insulin. Although not observed for proinsulin folding or insulin-chain recombination, the isomer retains ordered secondary structure and a compact hydrophobic core. Compariso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc23b574942f1bf0faafa81d39c3ded
https://doi.org/10.1038/nsb0295-129
https://doi.org/10.1038/nsb0295-129
Publikováno v:
Hormone Research. 41:93-96
The Diabetes Control and Complications Trial has emphasized the need for improved control of blood glucose as a means to diminish long-term complications of diabetes. LysPro-insulin is an analog of human insulin whose design was modeled on structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3e626c6fb6f1ca1631163b97fc1f2c
https://doi.org/10.1159/000183967
https://doi.org/10.1159/000183967
Autor:
Bruce H. Frank, Ronald E. Chance
Publikováno v:
Diabetes Care. 16:133-142
This paper provides some historical aspects on the research and development of Humulin® (rDNA origin), the first human health-care product derived from rDNA technology more than a decade ago. Also referred to as biosynthetic human insulin, Humulin®
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145ed7f5d20d3de51e4c97183a0b9e97
https://doi.org/10.2337/diacare.16.3.133
https://doi.org/10.2337/diacare.16.3.133
Autor:
Gary G. Berntson, Ronald E. Chance, James Arthur Hoffman, William B. Zipf, Thomas M. O'Dorisio
Publikováno v:
Peptides. 14:497-503
Prader-Willi syndrome is characterized by dramatic hyperphagia and morbid obesity, and is associated with a deficiency in basal and meal-stimulated serum pancreatic polypeptide (PP) levels. Intravenous infusions of pancreatic polypeptide (90 min, 50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0025eba94eea832481add28a8358e032
https://doi.org/10.1016/0196-9781(93)90138-7
https://doi.org/10.1016/0196-9781(93)90138-7
Autor:
John B. Hanks, Holly A. Jones, James A. Hoffmann, Dana K. Andersen, Arthur E. Freedlender, Dariush Elahi, Ronald E. Chance, Stephen B. Cox, Henry M. Prillaman, Gregory E. Cornett, Terry L. Flanagan
Publikováno v:
Annals of Surgery. 216:574-582
Surgical alterations of the pancreas result in anatomic changes that can affect postoperative glucose metabolism. Pancreas transplantation results in reduction of beta-cell mass, systemic release of insulin, and denervation. The authors hypothesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3dd8d72acc94ac1fa01d65210b43294
https://doi.org/10.1097/00000658-199211000-00009
https://doi.org/10.1097/00000658-199211000-00009