Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Ronald E Cannon"'
Autor:
Birandra K. Sinha, Carl D. Bortner, Alan K. Jarmusch, Erik J. Tokar, Carri Murphy, Xian Wu, Heather Winter, Ronald E. Cannon
Publikováno v:
Cells, Vol 12, Iss 12, p 1626 (2023)
Our recent studies show that the treatment of human ovarian tumor cells with NCX4040 results in significant depletions of cellular glutathione, the formation of reactive oxygen/nitrogen species and cell death. NCX4040 is also cytotoxic to several hum
Externí odkaz:
https://doaj.org/article/a81615ed59ff4015be0775e09dc25c83
Autor:
Birandra Kumar Sinha, Carl D Bortner, Alan K Jatmusch, Erik J Tokar, Carri Murphey, Xian Wu, Heather Winter, Ronald E Cannon
Our recent studies showed that the treatment of human ovarian tumor cells with NCX4040 resulted in significant depletions of cellular glutathione, formation of reactive oxygen/nitrogen species and cell death. NCX4040 is also cytotoxic to several huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16c034952c57ad15038c6e76e7e09baf
https://doi.org/10.20944/preprints202305.1679.v1
https://doi.org/10.20944/preprints202305.1679.v1
Autor:
Sascha C.T. Nicklisch, Andrew W Trexler, Ronald E. Cannon, Linda S. Birnbaum, Gabriel A. Knudsen
Publikováno v:
Toxicol Sci
2,4,6-Tribromophenol (TBP, CAS No. 118-79-6) is a brominated chemical used in the production of flame-retardant epoxy resins and as a wood preservative. In marine environments, TBP is incorporated into shellfish and consumed by predatory fish. Food p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00229803edadcd3275bf123556a5209c
https://doi.org/10.1093/toxsci/kfz155
https://doi.org/10.1093/toxsci/kfz155
Publikováno v:
Toxicol Sci
Tetrabromobisphenol A (TBBPA, CAS No. 79-94-7) is a brominated flame retardant used in 90% of epoxy coated circuit boards. Exposures to TBBPA can induce neurotoxicity and disrupt MAPK, estrogen, thyroid, and PPAR-associated signaling pathways. Becaus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dece77f65dde83e146e01827394a8ae
https://doi.org/10.1093/toxsci/kfz059
https://doi.org/10.1093/toxsci/kfz059
Autor:
Ronald E. Cannon, Linda S. Birnbaum, Christopher T. Juberg, Andrew W. Trexler, Alicia C. Richards, Gabriel A. Knudsen, Birandra K. Sinha
Publikováno v:
Environmental Health Perspectives
Background: Ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid (GenX) is a replacement for perfluorooctanoic acid in the production of fluoropolymers used in a variety of consumer products. GenX alters fetal development and antibody pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8739f572ba7ae67bfd3217397377d5
https://doi.org/10.1289/ehp5884
https://doi.org/10.1289/ehp5884
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1862:2806-2814
Background Development of resistance to chemotherapy drugs is a significant problem in treating human malignancies in the clinic. Overexpression of drug efflux proteins, including P-170 glycoprotein (P-gp), an ATP-dependent efflux protein, is one of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c0b385d43ae8b0cb4adde81ae06741
https://doi.org/10.1016/j.bbagen.2018.08.021
https://doi.org/10.1016/j.bbagen.2018.08.021
Publikováno v:
BioTechniques, Vol 27, Iss 2, Pp 278-280 (1999)
Externí odkaz:
https://doaj.org/article/f5fb15a630d6493c8fda8582883b69bb
Autor:
David B. Banks, Gary N.Y. Chan, David S. Miller, Emily V. Mesev, Ronald E. Cannon, Rebecca A Evans
Publikováno v:
Neuroscience Letters. 639:103-113
P-glycoprotein (P-gp), Breast cancer resistance protein (BCRP) and Multidrug resistance-associated protein 2 (MRP2) residing at the blood-brain barrier (BBB) and the blood-spinal cord barrier (BSCB) are major obstacles for drug delivery to the Centra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7fa4fc0f681fbdbbe0cfe0f45e5a27
https://doi.org/10.1016/j.neulet.2016.12.049
https://doi.org/10.1016/j.neulet.2016.12.049
Publikováno v:
Molecular Pharmacology. 91:373-382
P-glycoprotein, an ATP-driven efflux pump, regulates permeability of the blood-brain barrier (BBB). Sphingolipids, endogenous to brain tissue, influence inflammatory responses and cell survival in vitro. Our laboratory has previously shown that sphin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b26f2ba9b60ab42c80a3d2c01f755c
https://doi.org/10.1124/mol.116.107169
https://doi.org/10.1124/mol.116.107169
Publikováno v:
Cancers, Vol 13, Iss 1680, p 1680 (2021)
Cancers
Volume 13
Issue 7
Cancers
Volume 13
Issue 7
The emergence of multidrug resistance (MDR) in the clinic is a significant problem for a successful treatment of human cancers. Overexpression of various ABC transporters (P-gp, BCRP and MRP’s), which remove anticancer drugs in an ATP-dependent man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93817f5c79e7c81d66a5cd9bdd05ead5
https://doi.org/10.3390/cancers13071680
https://doi.org/10.3390/cancers13071680