Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ronald Dirkx"'
Publikováno v:
Circulation Research. 121
Epicardium-derived progenitor cell (EPDC) activation after injury is a cardio-restorative mechanism in the zebrafish heart, but this response is limited in adult mammals. Identification of mechanisms that regulate adult EPDC function is critical to e
Autor:
Michael A Trembley, Deanne M Mickelson, Ronald Dirkx, Jeffrey D Alexis, Christine Moravec, Eric M Small
Publikováno v:
Circulation Research. 121
Intercellular communication is essential for coordinating the contraction of cardiomyocytes. This synchrony is established by coupling electrical activity and force transmission at specialized junctions called intercalated discs (ICDs). We have recen
Autor:
Britta Schroth-Diez, Mihail Sarov, Thomas Kurth, Michele Solimena, Andreas Müller, Stephan Speier, B. P. Mulligan, Konstantinos Anastassiadis, Yannis Kalaidzidis, Carla Münster, Yanmei Liu, Michael Gerlach, Ronald Dirkx, Anna Ivanova, Cordula Andree, Marc Bickle
Publikováno v:
Diabetes
Insulin is stored within the secretory granules of pancreatic β-cells, and impairment of its release is the hallmark of type 2 diabetes. Preferential exocytosis of newly synthesized insulin suggests that granule aging is a key factor influencing ins
Autor:
Michele Solimena, Ronald Dirkx
Publikováno v:
Journal of Diabetes Investigation. 3:339-346
The failure of pancreatic β-cells to supply insulin in quantities sufficient to maintain euglycemia is a hallmark of type 2 diabetes. Perturbation of β-cell cholesterol homeostasis, culminating in elevated intracellular cholesterol levels, impairs
Autor:
Michele Solimena, Erdinc Sezgin, Michal Grzybek, Kai Simons, Petra Schwille, Ünal Coskun, Theresia Gutmann, Ilya Levental, Ronald Dirkx, Tomasz Buhl
Publikováno v:
PLoS ONE 10:e0123930 (2015)
PLoS One
PLoS ONE, Vol 10, Iss 4, p e0123930 (2015)
PLoS ONE
PLoS One
PLoS ONE, Vol 10, Iss 4, p e0123930 (2015)
PLoS ONE
Lateral compositional and physicochemical heterogeneity is a ubiquitous feature of cellular membranes on various length scales, from molecular assemblies to micrometric domains. Segregated lipid domains of increased local order, referred to as rafts,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d514dde3671ecc714440f4c486b96297
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=44477
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=44477
Autor:
Juha M. Torkko, Antje Viehrig, Michele Solimena, Barbara Borgonovo, Martina Lachnit, Carolin Wegbrod, Ronald Dirkx, Carla Münster, Anke Sönmez, Mario R. Ermácora, Mauricio P. Sica, María E. Primo, Anne Friedrich, Elisa Vergari
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
The type 1 diabetes autoantigen ICA512/IA-2/RPTPN is a receptor protein tyrosine phosphatase of the insulin secretory granules (SGs) which regulates the size of granule stores, possibly via cleavage/signaling of its cytosolic tail. The role of its ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905548a7104ac267c0ed211014503c1a
http://sedici.unlp.edu.ar/handle/10915/86902
http://sedici.unlp.edu.ar/handle/10915/86902
Autor:
Ronald, Dirkx, Michele, Solimena
Publikováno v:
Journal of Diabetes Investigation
The failure of pancreatic β‐cells to supply insulin in quantities sufficient to maintain euglycemia is a hallmark of type 2 diabetes. Perturbation of β‐cell cholesterol homeostasis, culminating in elevated intracellular cholesterol levels, impa
Publikováno v:
European Journal of Neuroscience. 11:2609-2620
The autoantigen of type I diabetes ICA512 is a receptor tyrosine phosphatase-like protein enriched in the secretory granule membranes of neurons and peptide secreting endocrine cells. While the function of ICA512 remains unknown, it is thought to lin
Publikováno v:
Endocrinology. 139:2727-2733
Treatment with 1 nM estradiol, 300 nM insulin, and 5 nM epidermal growth factor induces secretory granule accumulation and prolactin storage in GH4C1 rat pituitary tumor cells. The same triple treatment induced more than 6-fold accumulation of both t
Autor:
Ronald Dirkx, Ela Sharma, Feisha Zhao, Janice R. Naegele, Erika Lukacsi, Michele Solimena, Abel Bult, Paul J. Lombroso
Publikováno v:
Scopus-Elsevier
The STEP family of protein tyrosine phosphatases is highly enriched within the CNS. Members of this family are alternatively spliced to produce both transmembrane and cytosolic variants. This manuscript describes the distinctive intracellular distrib