Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ronald De Vlaming"'
Autor:
Hans van Kippersluis, Pietro Biroli, Rita Dias Pereira, Titus J. Galama, Stephanie von Hinke, S. Fleur W. Meddens, Dilnoza Muslimova, Eric A. W. Slob, Ronald de Vlaming, Cornelius A. Rietveld
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Measurement error in polygenic indices (PGIs) attenuates the estimation of their effects in regression models. We analyze and compare two approaches addressing this attenuation bias: Obviously Related Instrumental Variables (ORIV) and the PG
Externí odkaz:
https://doaj.org/article/9b2301c9e74b47289315b4c95041393b
Multivariate estimation of factor structures of complex traits using SNP-based genomic relationships
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Heritability and genetic correlation can be estimated from genome-wide single-nucleotide polymorphism (SNP) data using various methods. We recently developed multivariate genomic-relatedness-based restricted maximum likelihood (MG
Externí odkaz:
https://doaj.org/article/4fc565e0deb04703976500ec4dd8d233
The identification of mediating effects using genome-based restricted maximum likelihood estimation.
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010638 (2023)
Mediation analysis is commonly used to identify mechanisms and intermediate factors between causes and outcomes. Studies drawing on polygenic scores (PGSs) can readily employ traditional regression-based procedures to assess whether trait M mediates
Externí odkaz:
https://doaj.org/article/7f914e77cff64f77854d736e19623472
Autor:
Ronald de Vlaming, Eric A. W. Slob, Philip R. Jansen, Alain Dagher, Philipp D. Koellinger, Patrick J. F. Groenen, Cornelius A. Rietveld
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Ronald de Vlaming and Eric Slob et al. present MGREML, a multivariate tool to estimate pairwise genetic correlations between multiple traits. They apply MGREML to UK Biobank data for 74 brain imaging phenotypes and 8 behavioral traits, demonstrating
Externí odkaz:
https://doaj.org/article/61965f8c3cfa45558858895d9c0d260e
Autor:
Travis T. Mallard, Richard Karlsson Linnér, Andrew D. Grotzinger, Sandra Sanchez-Roige, Jakob Seidlitz, Aysu Okbay, Ronald de Vlaming, S. Fleur W. Meddens, Abraham A. Palmer, Lea K. Davis, Elliot M. Tucker-Drob, Kenneth S. Kendler, Matthew C. Keller, Philipp D. Koellinger, K. Paige Harden
Publikováno v:
Cell Genomics, Vol 2, Iss 6, Pp 100140- (2022)
Summary: Understanding which biological pathways are specific versus general across diagnostic categories and levels of symptom severity is critical to improving nosology and treatment of psychopathology. Here, we combine transdiagnostic and dimensio
Externí odkaz:
https://doaj.org/article/e46aa5b1293c4d778b4c92cbacfead66
Autor:
Ronald de Vlaming, Aysu Okbay, Cornelius A Rietveld, Magnus Johannesson, Patrik K E Magnusson, André G Uitterlinden, Frank J A van Rooij, Albert Hofman, Patrick J F Groenen, A Roy Thurik, Philipp D Koellinger
Publikováno v:
PLoS Genetics, Vol 13, Iss 1, p e1006495 (2017)
Large-scale genome-wide association results are typically obtained from a fixed-effects meta-analysis of GWAS summary statistics from multiple studies spanning different regions and/or time periods. This approach averages the estimated effects of gen
Externí odkaz:
https://doaj.org/article/39f9049b84b84185a20acd38803b72da
Autor:
Scott I. Vrieze, Mengzhen Liu, K. Paige Harden, Trey Ideker, Karin J. H. Verweij, Kathleen Mullan Harris, Sandra Sanchez-Roige, Abraham A. Palmer, Ronald de Vlaming, Dajiang J. Liu, Irwin D. Waldman, Philipp Koellinger, Richard Karlsson Linnér, James W. Madole, Peter B. Barr, Joel Gelernter, Andrew D. Grotzinger, Morgan N. Driver, Rachel L. Kember, Emma C. Johnson, Jorim J. Tielbeek, Henry R. Kranzler, Sara Brin Rosenthal, Holly E. Poore, Elliot M. Tucker-Drob, Danielle M. Dick, Travis T. Mallard, Hang Zhou, Joëlle A. Pasman
Publikováno v:
Nature Neuroscience, 376
Nature Neuroscience, 376, 1835
Nature Neuroscience, 24(10), 1367-1376. Nature Publishing Group
Nature neuroscience, 24(10), 1367-1376. Nature Publishing Group
COGA Collaborators 2021, ' Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction ', Nature Neuroscience, vol. 24, no. 10, pp. 1367-1376 . https://doi.org/10.1038/s41593-021-00908-3
Nature Neuroscience, 376, 1835
Nature Neuroscience, 24(10), 1367-1376. Nature Publishing Group
Nature neuroscience, 24(10), 1367-1376. Nature Publishing Group
COGA Collaborators 2021, ' Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction ', Nature Neuroscience, vol. 24, no. 10, pp. 1367-1376 . https://doi.org/10.1038/s41593-021-00908-3
Contains fulltext : 237013.pdf (Publisher’s version ) (Closed access) Behaviors and disorders related to self-regulation, such as substance use, antisocial behavior and attention-deficit/hyperactivity disorder, are collectively referred to as exter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33064b7be824a83f9adfe5dee2684fcb
http://www.scopus.com/inward/record.url?scp=85114020547&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85114020547&partnerID=8YFLogxK
Autor:
Philip R. Jansen, Patrick J. F. Groenen, Cornelius A. Rietveld, Ronald de Vlaming, Alain Dagher, Philipp Koellinger, Eric A. W. Slob
Publikováno v:
Communications Biology
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P D, Groenen, P J F & Rietveld, C A 2021, ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ', Communications biology, vol. 4, 1180, pp. 1-9 . https://doi.org/10.1038/s42003-021-02712-y
Communications Biology, 4(1):1180. Springer Nature
Communications biology, 4:1180, 1-9. Nature Research
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P D, Groenen, P J F & Rietveld, C A 2021, ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ', Communications Biology, vol. 4, no. 1, 1180 . https://doi.org/10.1038/s42003-021-02712-y
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P, Groenen, P J F & Rietveld, C A 2021 ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ' bioRxiv, bioRxiv . https://doi.org/10.1101/2021.04.19.440478
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P D, Groenen, P J F & Rietveld, C A 2021, ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ', Communications biology, vol. 4, 1180, pp. 1-9 . https://doi.org/10.1038/s42003-021-02712-y
Communications Biology, 4(1):1180. Springer Nature
Communications biology, 4:1180, 1-9. Nature Research
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P D, Groenen, P J F & Rietveld, C A 2021, ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ', Communications Biology, vol. 4, no. 1, 1180 . https://doi.org/10.1038/s42003-021-02712-y
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P, Groenen, P J F & Rietveld, C A 2021 ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ' bioRxiv, bioRxiv . https://doi.org/10.1101/2021.04.19.440478
Human variation in brain morphology and behavior are related and highly heritable. Yet, it is largely unknown to what extent specific features of brain morphology and behavior are genetically related. Here, we introduce a computationally efficient ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c069ca86ebfb6186627a8a306e0d249
https://doi.org/10.1038/s42003-021-02712-y
https://doi.org/10.1038/s42003-021-02712-y
Autor:
Fumiaki Imamura, George Davey Smith, Chanwook Lee, Nicholas J. Wareham, M. Arfan Ikram, George McMahon, Aysu Okbay, Frank J. A. van Rooij, Peter Bowers, Carson C. Chow, Patrick Turley, Ronald de Vlaming, Jian'an Luan, Oscar H. Franco, Trudy Voortman, Daniel J. Benjamin, André G. Uitterlinden, Casper A.P. Burik, Nita G. Forouhi, K. Paige Harden, Pauline M Emmett, Cornelius A. Rietveld, Juan R. González, Bruce H. R. Wolffenbuttel, Philipp Koellinger, Mark Alan Fontana, James J. Lee, David Cesarini, Harold Snieder, Kim Valeska Emilie Braun, Emma L Anderson, Jana V. van Vliet-Ostaptchouk, Peter J. van der Most, Richard Karlsson Linnér, Susan M. Ring, Claudia Langenberg, Tonũ Esko, Fernando Rivadeneira, Kaitlin H Wade, Jessica C. Kiefte-de Jong, Taulant Muka, Mohsen Ghanbari, S. Fleur W. Meddens
Publikováno v:
Molecular Psychiatry, 26, 2056-2069. NATURE PUBLISHING GROUP
the 23 and Me Research Team 2020, ' Genomic analysis of diet composition finds novel loci and associations with health and lifestyle ', Molecular Psychiatry, vol. 2020 . https://doi.org/10.1038/s41380-020-0697-5
Molecular Psychiatry. Nature Publishing Group
Molecular Psychiatry
23Andme Research Team, EPIC-InterAct Consortium & LifeLines Cohort Study 2020, ' Genomic analysis of diet composition finds novel loci and associations with health and lifestyle ', Molecular Psychiatry, vol. 26, no. 6, pp. 2056-2069 . https://doi.org/10.1038/s41380-020-0697-5
Molecular psychiatry, vol 26, iss 6
Molecular Psychiatry, 26. Nature Publishing Group
Molecular Psychiatry, 26(6), 2056-2069. Nature Publishing Group
the 23 and Me Research Team 2020, ' Genomic analysis of diet composition finds novel loci and associations with health and lifestyle ', Molecular Psychiatry, vol. 2020 . https://doi.org/10.1038/s41380-020-0697-5
Molecular Psychiatry. Nature Publishing Group
Molecular Psychiatry
23Andme Research Team, EPIC-InterAct Consortium & LifeLines Cohort Study 2020, ' Genomic analysis of diet composition finds novel loci and associations with health and lifestyle ', Molecular Psychiatry, vol. 26, no. 6, pp. 2056-2069 . https://doi.org/10.1038/s41380-020-0697-5
Molecular psychiatry, vol 26, iss 6
Molecular Psychiatry, 26. Nature Publishing Group
Molecular Psychiatry, 26(6), 2056-2069. Nature Publishing Group
We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We identified 21 unique, approximately independent lead SNPs. Fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d8d05f37a3c2c398c885bc70c40da9
https://www.nature.com/articles/s41380-020-0697-5
https://www.nature.com/articles/s41380-020-0697-5
Autor:
Ronald de Vlaming, Aysu Okbay, Hyeokmoon Kweon, Kathryn Paige Harden, Daphne Martschenko, Philipp Koellinger, Thomas A. DiPrete, Casper A.P. Burik, Richard Karlsson Linnér
Publikováno v:
SSRN Electronic Journal.
We develop a polygenic index for individual income and examine random differences in this index with lifetime outcomes in a sample of ~35,000 biological siblings. We find that genetic fortune for higher income causes greater socio-economic status and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47350624f56a3f3633a0c9241e49e779
https://doi.org/10.2139/ssrn.3682041
https://doi.org/10.2139/ssrn.3682041