Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Ronald D.G. McKay"'
Autor:
Abigail Mariga, Ian M. Hardern, Huijun Wei, Roland Bürli, Daniel R. Weinberger, Steven Wesolowski, Ronald D.G. McKay, Alan J. Cross, Hongming Chen, Kara Herlihy, Glen Ernst, James C. Barrow, Nicholas J. Brandon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3231-3235
Due to increased interest in As(III) S-adenosylmethionine methyltransferase (AS3MT), a search for chemical probes that can help elucidate function was initiated. A homology model was built based on related enzymes, and virtual screening produced 426
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df456334df7ee822874b062b9778e38c
https://doi.org/10.1016/j.bmcl.2018.08.012
https://doi.org/10.1016/j.bmcl.2018.08.012
Autor:
Ronald D.G. McKay, Suel Kee Kim, Anne L. Plant, Daniel J. Hoeppner, Peter Bajcsy, Steven P. Lund, Ya-Shian Li-Baboud, Adele P. Peskin, Josh G. Chenoweth, Oleg Aulov, Michael Halter
The visual inspection of pluripotent stem cell colonies by microscopy is widely used as a primary method to assess the quality of the preparations and degree of pluripotency. The lack of ground truth and the possible inconsistency of evaluations from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbfc3ffd44168a8d17e0d6246dab4eea
Autor:
Daniel R. Weinberger, Marcelo Diaz-Bustamante, Nicolas A. Olivares, Pasko Rakic, Suel Kee Kim, Roland Bürli, Seungmae Seo, Shaojie Ma, Nicholas J. Brandon, Josh G. Chenoweth, Nicola Micali, Daniel J. Hoeppner, Elana J. Fertig, Yanhong Wang, Jon I. Arellano, Brian G. Rash, Genevieve Stein-O’Brien, Alan J. Cross, Kristen R. Maynard, Carlo Colantuoni, Nenad Sestan, Joo Heon Shin, Ronald D.G. McKay
Publikováno v:
Cell reports
Cell Reports, Vol 31, Iss 5, Pp-(2020)
Cell Reports, Vol 31, Iss 5, Pp-(2020)
SUMMARY Better understanding of the progression of neural stem cells (NSCs) in the developing cerebral cortex is important for modeling neurogenesis and defining the pathogenesis of neuropsychiatric disorders. Here, we use RNA sequencing, cell imagin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb805a5b3d34d2c707163eee1a5b4e10
https://doi.org/10.1101/577544
https://doi.org/10.1101/577544
Autor:
Marcelo Diaz-Bustamante, Dennisse V. Jimenez, Keri Martinowich, Ahmad Jalloh, Briony J. Catlow, Daniel Paredes, Amritha Jaishankar, Ronald D.G. McKay, Seungmae Seo, Daniel J. Hoeppner
Publikováno v:
Brain Research. 1754:147254
Schizophrenia is a neurodevelopmental psychiatric disorder, encompassing genetic and environmental risk factors. For several decades, investigators have been implementing the use of lesions of the neonatal rodent hippocampus to model schizophrenia, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c31d358b72c526741cb54e2c8e8ce6b9
https://doi.org/10.1016/j.brainres.2020.147254
https://doi.org/10.1016/j.brainres.2020.147254
Autor:
Michael F. Ochs, Elana J. Fertig, Michael Considine, Alexander V. Favorov, Shawn Sivy, Daria A. Gaykalova, Sijia Li, Emily Flam, Ronald D.G. McKay, Luigi Marchionni, Genevieve Stein-O’Brien, Thomas Sherman, Theresa Guo, Carlo Colantuoni, Jacob Carey, Wai Shing Lee
Publikováno v:
Bioinformatics. 33:1892-1894
Summary Non-negative Matrix Factorization (NMF) algorithms associate gene expression with biological processes (e.g. time-course dynamics or disease subtypes). Compared with univariate associations, the relative weights of NMF solutions can obscure b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6953a22abf5bf7598814a1e785c4c4
https://doi.org/10.1093/bioinformatics/btx058
https://doi.org/10.1093/bioinformatics/btx058
Autor:
Amritha Jaishankar, Brady J. Maher, Alana Lescure, Kamel Shibbani, Ronald D.G. McKay, Leonardo Collado-Torres, Daniel J Hiler, William S Ulrich, Thomas M. Hyde, Alan J. Cross, Jose A. Apud, Josh G. Chenoweth, Gregory R. Hamersky, Nicola Micali, Keri Martinowich, Emily E. Burke, Stephanie Cerceo Page, Nicholas J. Brandon, Suel Kee Kim, BaDoi N. Phan, Stephen A. Semick, Anandita Rajpurohit, Joel E. Kleinman, Richard E. Straub, Andrew E. Jaffe, Yanhong Wang, Huei Ying Chen, Amanda J. Price, Daniel J. Hoeppner, Daniel R. Weinberger, Joo Heon Shin, James C. Barrow, Cristian Valencia, Roland Bürli, Karen F. Berman
SummaryHuman induced pluripotent stem cells (hiPSCs) are a powerful model of neural differentiation and maturation. We present a hiPSC transcriptomics resource on corticogenesis from 5 iPSC donor and 13 subclonal lines across nine time points over 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90733a635473e79527a5be7ab30e380
Autor:
Michael M. Gottesman, Wei Zheng, Kevin G. Chen, Kye-Yoon Park, Barbara S. Mallon, Ronald D.G. McKay, Pamela Gehron Robey
Publikováno v:
Trends in molecular medicine. 24(9)
Use of human pluripotent stem cells (hPSCs) and their differentiated derivatives have led to recent proof-of-principle drug discoveries, defining a pathway to the implementation of hPSC-based drug discovery (hPDD). Current hPDD strategies, however, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec3383aa5a0c6daff7a8bf46febf9b5
https://pubmed.ncbi.nlm.nih.gov/30006147
https://pubmed.ncbi.nlm.nih.gov/30006147
Autor:
Josh G. Chenoweth, Andreas Androutsellis-Theotokis, Carlo Colantuoni, Steven W. Poser, Jimmy Masjkur, George P. Chrousos, Stefan R. Bornstein, Ronald D.G. McKay
Publikováno v:
Stem Cells Translational Medicine. 4:1251-1257
Interest is great in the new molecular concepts that explain, at the level of signal transduction, the process of reprogramming. Usually, transcription factors with developmental importance are used, but these approaches give limited information on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c9527a50d6316cf0450975465ab144
https://doi.org/10.5966/sctm.2015-0105
https://doi.org/10.5966/sctm.2015-0105
Publikováno v:
Stem cells (Dayton, Ohio). 36(1)
Lineage commitment and differentiation of skeletal stem cells/bone marrow stromal cells (SSCs/BMSCs, often called bone marrow-derived “mesenchymal stem/stromal” cells) offer an important opportunity to study skeletal and hematopoietic diseases, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59363f265e16fa379f4d3a7d4a1d511
https://pubmed.ncbi.nlm.nih.gov/28948674
https://pubmed.ncbi.nlm.nih.gov/28948674
Autor:
Olivia Corradin, Gabriel E. Zentner, Paul J. Tesar, Peter C. Scacheri, Alina Saiakhova, Ronald D.G. McKay, Gregory E. Crawford, Daniel C. Factor, Josh G. Chenoweth, Lingyun Song
Publikováno v:
Cell Stem Cell. 14:854-863
Summary Naive mouse embryonic stem cells (mESCs) and primed epiblast stem cells (mEpiSCs) represent successive snapshots of pluripotency during embryogenesis. Using transcriptomic and epigenomic mapping we show that a small fraction of transcripts ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba01f0587949185560ad50fffe8084f
https://doi.org/10.1016/j.stem.2014.05.005
https://doi.org/10.1016/j.stem.2014.05.005