Zobrazeno 1 - 10
of 343
pro vyhledávání: '"Ronald D Vale"'
Autor:
Alexandra M Schnoes, Noah H Green, Thi A Nguyen, Ronald D Vale, Sarah S Goodwin, Shannon L Behrman
Publikováno v:
PLoS Biology, Vol 22, Iss 1, p e3002458 (2024)
iBiology Courses provide trainees with just-in-time learning resources to become effective researchers. These courses can help scientists build core research skills, plan their research projects and careers, and learn from scientists with diverse bac
Externí odkaz:
https://doaj.org/article/8d416095738743598d9aebb6254da43c
Publikováno v:
eLife, Vol 10 (2021)
Macrophages destroy pathogens and diseased cells through Fcγ receptor (FcγR)-driven phagocytosis of antibody-opsonized targets. Phagocytosis requires activation of multiple FcγRs, but the mechanism controlling the threshold for response is unclear
Externí odkaz:
https://doaj.org/article/22326acb213c44e0bb2e15c5800764e0
Autor:
Jonathon A Ditlev, Anthony R Vega, Darius Vasco Köster, Xiaolei Su, Tomomi Tani, Ashley M Lakoduk, Ronald D Vale, Satyajit Mayor, Khuloud Jaqaman, Michael K Rosen
Publikováno v:
eLife, Vol 8 (2019)
During T cell activation, biomolecular condensates form at the immunological synapse (IS) through multivalency-driven phase separation of LAT, Grb2, Sos1, SLP-76, Nck, and WASP. These condensates move radially at the IS, traversing successive radiall
Externí odkaz:
https://doaj.org/article/4967687a42254a76a7c714088eb669a4
Publikováno v:
eLife, Vol 7 (2018)
Centrioles are cylindrical assemblies comprised of 9 singlet, doublet, or triplet microtubules, essential for the formation of motile and sensory cilia. While the structure of the cilium is being defined at increasing resolution, centriolar structure
Externí odkaz:
https://doaj.org/article/991ce68f72a448a09fb216ca15a158a9
Autor:
Kara L McKinley, Nico Stuurman, Loic A Royer, Christoph Schartner, David Castillo-Azofeifa, Markus Delling, Ophir D Klein, Ronald D Vale
Publikováno v:
eLife, Vol 7 (2018)
Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches. The mechanisms that
Externí odkaz:
https://doaj.org/article/1ecc5bf280c04ae08f3035b81a637af0
Autor:
Meghan A Morrissey, Adam P Williamson, Adriana M Steinbach, Edward W Roberts, Nadja Kern, Mark B Headley, Ronald D Vale
Publikováno v:
eLife, Vol 7 (2018)
Chimeric antigen receptors (CARs) are synthetic receptors that reprogram T cells to kill cancer. The success of CAR-T cell therapies highlights the promise of programmed immunity and suggests that applying CAR strategies to other immune cell lineages
Externí odkaz:
https://doaj.org/article/b6c213511ca34e6e95a2eeaeb0ed0238
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 5, p e1005473 (2017)
Externí odkaz:
https://doaj.org/article/a55322c833fb4c2bbc8f0321782b838c
Autor:
Ronald D Vale, Anthony A Hyman
Publikováno v:
eLife, Vol 5 (2016)
The job of a scientist is to make a discovery and then communicate this new knowledge to others. For a scientist to be successful, he or she needs to be able to claim credit or priority for discoveries throughout their career. However, despite being
Externí odkaz:
https://doaj.org/article/2be3c6b9a643437c9117d37ebef3f312
Publikováno v:
eLife, Vol 4 (2015)
Passage through mitosis is driven by precisely-timed changes in transcriptional regulation and protein degradation. However, the importance of translational regulation during mitosis remains poorly understood. Here, using ribosome profiling, we find
Externí odkaz:
https://doaj.org/article/c939c288f3024637853fb86b8491c48d
A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region
Publikováno v:
eLife, Vol 3 (2014)
Cytoplasmic dynein, a microtubule-based motor protein, transports many intracellular cargos by means of its light intermediate chain (LIC). In this study, we have determined the crystal structure of the conserved LIC domain, which binds the motor hea
Externí odkaz:
https://doaj.org/article/fb088b2b884a4368904703967d69fa52