Zobrazeno 1 - 10
of 521
pro vyhledávání: '"Ronald D Vale"'
Autor:
Alexandra M. Schnoes, Noah H. Green, Thi A. Nguyen, Ronald D. Vale, Sarah S. Goodwin, Shannon L. Behrman
Publikováno v:
PLoS Biology, Vol 22, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/ca705919ba234c80828485f40df7e9e6
Publikováno v:
eLife, Vol 10 (2021)
Macrophages destroy pathogens and diseased cells through Fcγ receptor (FcγR)-driven phagocytosis of antibody-opsonized targets. Phagocytosis requires activation of multiple FcγRs, but the mechanism controlling the threshold for response is unclear
Externí odkaz:
https://doaj.org/article/22326acb213c44e0bb2e15c5800764e0
Autor:
Jonathon A Ditlev, Anthony R Vega, Darius Vasco Köster, Xiaolei Su, Tomomi Tani, Ashley M Lakoduk, Ronald D Vale, Satyajit Mayor, Khuloud Jaqaman, Michael K Rosen
Publikováno v:
eLife, Vol 8 (2019)
During T cell activation, biomolecular condensates form at the immunological synapse (IS) through multivalency-driven phase separation of LAT, Grb2, Sos1, SLP-76, Nck, and WASP. These condensates move radially at the IS, traversing successive radiall
Externí odkaz:
https://doaj.org/article/4967687a42254a76a7c714088eb669a4
Autor:
Crystal L. Mackall, Ronald D. Vale, Alexander R. Dunn, Peng Xu, Rachel C. Lynn, Johanna Theruvath, Volker Wiebking, Sang M. Nguyen, Sabine Heitzeneder, Rebecca M. Richards, Aidan M. Tousley, Evan W. Weber, Meena Kadapakkam, June H. Myklebust, Louai Labanieh, Vipul T. Vachharajani, Rui Dong, Elena Sotillo, Skyler P. Rietberg, Robbie G. Majzner
Supplemental Table 1 Supplementary Figures 1-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311f40ebf949712905c9428d4941d39e
https://doi.org/10.1158/2159-8290.22535654.v1
https://doi.org/10.1158/2159-8290.22535654.v1
Autor:
Crystal L. Mackall, Ronald D. Vale, Alexander R. Dunn, Peng Xu, Rachel C. Lynn, Johanna Theruvath, Volker Wiebking, Sang M. Nguyen, Sabine Heitzeneder, Rebecca M. Richards, Aidan M. Tousley, Evan W. Weber, Meena Kadapakkam, June H. Myklebust, Louai Labanieh, Vipul T. Vachharajani, Rui Dong, Elena Sotillo, Skyler P. Rietberg, Robbie G. Majzner
Insufficient reactivity against cells with low antigen density has emerged as an important cause of chimeric antigen receptor (CAR) T-cell resistance. Little is known about factors that modulate the threshold for antigen recognition. We demonstrate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f70c30aecf09a358b25065ab2c1e623f
https://doi.org/10.1158/2159-8290.c.6547904.v1
https://doi.org/10.1158/2159-8290.c.6547904.v1
Autor:
Zhen Chen, Garrett A. Greenan, Momoko Shiozaki, Yanxin Liu, Will M. Skinner, Xiaowei Zhao, Shumei Zhao, Rui Yan, Zhiheng Yu, Polina V. Lishko, David A. Agard, Ronald D. Vale
Publikováno v:
Nature structural & molecular biology, vol 30, iss 3
The flagella of mammalian sperm display non-planar, asymmetric beating, in contrast to the planar, symmetric beating of flagella from sea urchin sperm and unicellular organisms. The molecular basis of this difference is unclear. Here, we perform in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881cae4ee42ed31ec076b0a409842aac
https://escholarship.org/uc/item/37m6f29w
https://escholarship.org/uc/item/37m6f29w
Autor:
Michael R. Das, Yeonji Chang, Rachel Anderson, Reuben A. Saunders, Nan Zhang, Colson P. Tomberlin, Ronald D. Vale, Ankur Jain
Publikováno v:
Proceedings of the National Academy of Sciences. 120
CAG trinucleotide repeat expansions cause several neurodegenerative diseases, including Huntington's disease and spinocerebellar ataxia. RNAs with expanded CAG repeats contribute to disease in two unusual ways. First, these repeat-containing RNAs may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18feb7a6fa2fcb97c1e9175bdba33cd9
https://doi.org/10.1073/pnas.2215071120
https://doi.org/10.1073/pnas.2215071120
Publikováno v:
eLife, Vol 7 (2018)
Centrioles are cylindrical assemblies comprised of 9 singlet, doublet, or triplet microtubules, essential for the formation of motile and sensory cilia. While the structure of the cilium is being defined at increasing resolution, centriolar structure
Externí odkaz:
https://doaj.org/article/991ce68f72a448a09fb216ca15a158a9
Autor:
Kara L McKinley, Nico Stuurman, Loic A Royer, Christoph Schartner, David Castillo-Azofeifa, Markus Delling, Ophir D Klein, Ronald D Vale
Publikováno v:
eLife, Vol 7 (2018)
Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches. The mechanisms that
Externí odkaz:
https://doaj.org/article/1ecc5bf280c04ae08f3035b81a637af0
Autor:
Meghan A Morrissey, Adam P Williamson, Adriana M Steinbach, Edward W Roberts, Nadja Kern, Mark B Headley, Ronald D Vale
Publikováno v:
eLife, Vol 7 (2018)
Chimeric antigen receptors (CARs) are synthetic receptors that reprogram T cells to kill cancer. The success of CAR-T cell therapies highlights the promise of programmed immunity and suggests that applying CAR strategies to other immune cell lineages
Externí odkaz:
https://doaj.org/article/b6c213511ca34e6e95a2eeaeb0ed0238