Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ronald D Seidel"'
Autor:
Sarah C Garrett-Thomson, Aldo Massimi, Elena V Fedorov, Jeffrey B Bonanno, Lisa Scandiuzzi, Brandan Hillerich, Ronald D Seidel, James D Love, Scott J Garforth, Chandan Guha, Steven C Almo
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233578 (2020)
The B7 family represents one of the best-studied subgroups within the Ig superfamily, yet new interactions continue to be discovered. However, this binding promiscuity represents a major challenge for defining the biological contribution of each spec
Externí odkaz:
https://doaj.org/article/27e3018279ae454bb113285e87c0fa4f
Autor:
Suwen Zhao, Ayano Sakai, Xinshuai Zhang, Matthew W Vetting, Ritesh Kumar, Brandan Hillerich, Brian San Francisco, Jose Solbiati, Adam Steves, Shoshana Brown, Eyal Akiva, Alan Barber, Ronald D Seidel, Patricia C Babbitt, Steven C Almo, John A Gerlt, Matthew P Jacobson
Publikováno v:
eLife, Vol 3 (2014)
Metabolic pathways in eubacteria and archaea often are encoded by operons and/or gene clusters (genome neighborhoods) that provide important clues for assignment of both enzyme functions and metabolic pathways. We describe a bioinformatic approach (g
Externí odkaz:
https://doaj.org/article/987f7767be6744a18463d2a7fd3a79e8
Autor:
Susan T Mashiyama, M Merced Malabanan, Eyal Akiva, Rahul Bhosle, Megan C Branch, Brandan Hillerich, Kevin Jagessar, Jungwook Kim, Yury Patskovsky, Ronald D Seidel, Mark Stead, Rafael Toro, Matthew W Vetting, Steven C Almo, Richard N Armstrong, Patricia C Babbitt
Publikováno v:
PLoS Biology, Vol 12, Iss 4, p e1001843 (2014)
The cytosolic glutathione transferase (cytGST) superfamily comprises more than 13,000 nonredundant sequences found throughout the biosphere. Their key roles in metabolism and defense against oxidative damage have led to thousands of studies over seve
Externí odkaz:
https://doaj.org/article/dd598339e1bd44de93570af2d943bd14
Autor:
Jian-Jung Pan, Jose O. Solbiati, Gurusankar Ramamoorthy, Brandan S. Hillerich, Ronald D. Seidel, John E. Cronan, Steven C. Almo, C. Dale Poulter
Publikováno v:
ACS Central Science, Vol 1, Iss 2, Pp 77-82 (2015)
Externí odkaz:
https://doaj.org/article/b1d25fd683124830885d3b7367f32a68
Autor:
Richard T. Piszczatowski, Emily Schwenger, Sriram Sundaravel, Catarina M. Stein, Yang Liu, Pamela Stanley, Amit Verma, Deyou Zheng, Ronald D. Seidel, Steven C. Almo, Robert A. Townley, Hannes E. Bülow, Ulrich Steidl
Publikováno v:
The Journal of experimental medicine. 219(11)
Cell surfaces display a wide array of molecules that confer identity. While flow cytometry and cluster of differentiation (CD) markers have revolutionized cell characterization and purification, functionally heterogeneous cellular subtypes remain unr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58b3995329adca22572b705fc84b1f0
https://pubmed.ncbi.nlm.nih.gov/36066492
https://pubmed.ncbi.nlm.nih.gov/36066492
Autor:
Hang Su, Mengyan Li, Ronald D. Seidel, Rodolfo J. Chaparro, Kaitlyn E. O'Connor, Harris Goldstein, A. Celikgil, R. Brad Jones, Ravit Arav-Boger, Danica M Lee, Scott J. Garforth, Steven C. Almo
Publikováno v:
J Clin Invest
To delineate the in vivo role of different costimulatory signals in activating and expanding highly functional virus-specific cytotoxic CD8+ T cells, we designed synTacs, infusible biologics which recapitulate antigen-specific T-cell activation signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668701f42053f153eb184c19db021aa4
https://pubmed.ncbi.nlm.nih.gov/34673568
https://pubmed.ncbi.nlm.nih.gov/34673568
Publikováno v:
Journal of the American Chemical Society. 129:4834-4839
The study of bound-state conformations of ligands interacting with proteins is important to the understanding of protein function and the design of drugs that alter function. Traditionally, transferred nuclear Overhauser effects (trNOEs), measured fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8c39ee8afb636977e321b2ace193fb
https://doi.org/10.1021/ja069145h
https://doi.org/10.1021/ja069145h
Autor:
Ronald D. Seidel, Frank M. Raushel, Rafael Toro, Jeffrey B. Bonanno, Alexander Fedorov, Nigel G. J. Richards, Yury Patskovsky, Elena V. Fedorov, B. Hillerich, Steven C. Almo, Anna Vladimirova
Publikováno v:
Journal of the American Chemical Society
5-Carboxyvanillate decarboxylase (LigW) catalyzes the conversion of 5-carboxyvanillate to vanillate in the biochemical pathway for the degradation of lignin. This enzyme was shown to require Mn(2+) for catalytic activity and the kinetic constants for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971482919ca27333f298d6d99efb1267
https://pubmed.ncbi.nlm.nih.gov/26714575
https://pubmed.ncbi.nlm.nih.gov/26714575
Publikováno v:
Biochemistry. 43:15393-15403
ADP ribosylation factors (Arfs) are members of a family of Ras-related GTPases that regulate a wide variety of intracellular signaling pathways, including the regulation of membrane traffic and organelle morphology. Arfs perform these functions throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06aeea6fd1beb4055d96b699141e8ee0
https://doi.org/10.1021/bi0490385
https://doi.org/10.1021/bi0490385
Publikováno v:
Journal of Biological Chemistry. 279:48307-48318
Conformational changes associated with nucleotide exchange or truncation of the N-terminal alpha-helix of human Arf1 have been investigated by using forms of easily acquired NMR data, including residual dipolar couplings and amide proton exchange rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9db99d24072c271f462f157f41804c
https://doi.org/10.1074/jbc.m402109200
https://doi.org/10.1074/jbc.m402109200