Emerging approaches in predictive toxicology

Autor: Nigel Greene, Ronald D. Snyder, Luoping Zhang, Marilyn J. Aardema, Shambhu K Roy, Cliona M. McHale, Sundaresan Venkatactahalam, Ivan N. Rich, Stefan Pfuhler

Publikováno v: Environmental and Molecular Mutagenesis. 55:679-688

Predictive toxicology plays an important role in the assessment of toxicity of chemicals and the drug development process. While there are several well-established in vitro and in vivo assays that are suitable for predictive toxicology, recent advanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcac1f8a02ae6e00d99fbbb72f021e8d
https://doi.org/10.1002/em.21885

Genetic toxicology in silico protocol

Autor: Markus Frericks, Franck Atienzar, Nichola Gellatly, Candice Y. Johnson, Lisa Beilke, Alessandro Brigo, Laura Custer, Brian A. Wall, Dave Bower, Penny Leavitt, Angela White, Helga Gerets, Ray Kemper, Krista L. Dobo, David Jones, Naomi L. Kruhlak, Ian Crooks, Tara S. Barton-Maclaren, Craig Zwickl, Mark T. D. Cronin, Kevin P. Cross, Michelle O. Kenyon, Jui-Hua Hsieh, Véronique Gervais, Anna Vuorinen, Andrea-Nicole Richarz, David Faulkner, Zoryana Cammerer, Ronald D. Snyder, Jedd Hillegass, Kristine L. Witt, James Harvey, Alexandre Paulino, Glenn J. Myatt, Phillip Bellion, Romualdo Benigni, Marie C. Fortin, Alexander Amberg, Robert A. Jolly, Ernst Ahlberg, Lidiya Stavitskaya, M. Vijayaray Reddy, Chia-Wen Hsu, Mark Powley, Tatyana Y. Doktorova, Scott Miller, Chandrika Moudgal, Masamitsu Honma, Benoît Schilter, Donald P. Quigley, David Woolley, Raymond R. Tice, Samantha E. Gad-McDonald, Pete Watts, Joerg Wichard, Reinhard Stidl, Joel P. Bercu, Andrew Teasdale, Wolfgang Muster, Catrin Hasselgren, Susanne Glowienke, Elena Lo Piparo, Yumi Akahori, Adam Woolley, Klaus Kümmerer, David T. Szabo, Jacky Van Gompel, Sunil Kulkarni, Alejandra Trejo-Martin, Lennart T. Anger, Scott A. Masten, Kevin A. Ford, Scott S. Auerbach, Ewan D. Booth

Publikováno v: Regul Toxicol Pharmacol
Hasselgren, C, Ahlberg, E, Akahori, Y, Amberg, A, Anger, L T, Atienzar, F, Auerbach, S, Beilke, L, Bellion, P, Benigni, R, Bercu, J, Booth, E D, Bower, D, Brigo, A, Cammerer, Z, Cronin, M T D, Crooks, I, Cross, K P, Custer, L, Dobo, K, Doktorova, T, Faulkner, D, Ford, K A, Fortin, M C, Frericks, M, Gad-McDonald, S E, Gellatly, N, Gerets, H, Gervais, V, Glowienke, S, Van Gompel, J, Harvey, J S, Hillegass, J, Honma, M, Hsieh, J H, Hsu, C W, Barton-Maclaren, T S, Johnson, C, Jolly, R, Jones, D, Kemper, R, Kenyon, M O, Kruhlak, N L, Kulkarni, S A, Kümmerer, K, Leavitt, P, Masten, S, Miller, S, Moudgal, C, Muster, W, Paulino, A, Lo Piparo, E, Powley, M, Quigley, D P, Reddy, M V, Richarz, A N, Schilter, B, Snyder, R D, Stavitskaya, L, Stidl, R, Szabo, D T, Teasdale, A, Tice, R R, Trejo-Martin, A, Vuorinen, A, Wall, B A, Watts, P, White, A T, Wichard, J, Witt, K L, Woolley, A, Woolley, D, Zwickl, C & Myatt, G J 2019, ' Genetic toxicology in silico protocol ', Regulatory Toxicology and Pharmacology, vol. 107, no. 104403, 104403 . https://doi.org/10.1016/j.yrtph.2019.104403

In silico toxicology (IST) approaches to rapidly assess chemical hazard, and usage of such methods is increasing in all applications but especially for regulatory submissions, such as for assessing chemicals under REACH as well as the ICH M7 guidelin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79c7543ee11579b9576d130b0cc8e19f
https://doi.org/10.1016/j.yrtph.2019.104403

Genetic toxicology in the 21st century: Reflections and future directions

Autor: Ann M. Richard, Ronald D. Snyder, Michael D. Waters, Brinda Mahadevan, Raymond A. Kemper, R. Daniel Benz, Raymond R. Tice

Publikováno v: Environmental and Molecular Mutagenesis. 52:339-354

A symposium at the 40th anniversary of the Environmental Mutagen Society, held from October 24–28, 2009 in St. Louis, MO, surveyed the current status and future directions of genetic toxicology. This article summarizes the presentations and provide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c822d337d505792a97fe9cebdbfdee31
https://doi.org/10.1002/em.20653

Possible structural and functional determinants contributing to the clastogenicity of pharmaceuticals

Autor: Ronald D. Snyder

Publikováno v: Environmental and Molecular Mutagenesis. 51:800-814

The battery of regulatory genotoxicity studies required in support of new drug registration has remained largely static since its inception some thirty years ago. The Ames mutagenicity assay still forms the foundation for this testing being highly re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c729a515cfeebde80186e46debc0c04
https://doi.org/10.1002/em.20626

Exploratory drug safety: A discovery strategy to reduce attrition in development

Autor: Craig Mahon, Mark E. Cartwright, Ronald D. Snyder, Paul McNamara, Prudence Bradley, John C. Hunter, Richard Morrison, Ying-Ying Zhou, Alan S. Bass

Publikováno v: Journal of Pharmacological and Toxicological Methods. 60:69-78

Identification of novel new molecules which hold the greatest promise of safe and effective therapies remains a continuous challenge to the pharmaceutical industry. This has led the industry to implement strategies for identification of the most prom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395fd4cdd38fffd79456e18d14baea2f
https://doi.org/10.1016/j.vascn.2009.04.194