Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ronald D, Fiedler"'
Autor:
Susan D. O'Lone, Maria Engel, Ronald D. Fiedler, Maik Schuler, Kelley E. Sanok, Krista L. Dobo, Catherine J. Thiffeault, Stephanie L. Coffing, Donna A. Dickinson, William C. Gunther, Thomas J. Shutsky
Publikováno v:
Environmental and Molecular Mutagenesis. 55:492-499
Ethyl methanesulfonate (EMS) was evaluated as part of the validation effort for the rat Pig-a mutation assay and compared with other well-established in vivo genotoxicity endpoints. Male Sprague-Dawley (SD) rats were given a daily dose of 0, 6.25, 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c0f71d6e3dccac49af2f77952153c43
https://doi.org/10.1002/em.21863
https://doi.org/10.1002/em.21863
Autor:
Zoryana Cammerer, Maik Schuler, Ronald D. Fiedler, Stephanie L. Coffing, Catherine J. Thiffeault, Krista L. Dobo, Thomas J. Shutsky, William C. Gunther
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 725:13-21
In recent years, experimental evidence has accumulated that supports the existence of sublinear dose–response relationships at low doses of DNA reactive mutagens. However, creating the in vivo data necessary to allow for a more detailed dose–resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d6685417e80cd573216b3ec6f58ab1
https://doi.org/10.1016/j.mrgentox.2011.06.005
https://doi.org/10.1016/j.mrgentox.2011.06.005
Autor:
William C. Gunther, Ann Schuermans, John Nicolette, Fabrice Nesslany, Ronald D. Fiedler, Stephen D. Dertinger, Céline Defrain, Laura Custer, Thomas J. Shutsky, Catherine J. Thiffeault, Robert H. Heflich, Paul Sonders, Amanda Giddings, Ljubica Krsmanovic, Javed A. Bhalli, Eleanor C. Wilde, Anthony M. Lynch, James T. MacGregor, Kevin Sweder, Osamu Tajima, Takafumi Kimoto, Andrew Henwood, Jing Shi, Terry Van Doninck, Souk Phonethepswath, Carol Gleason, Bas-jan M. van der Leede, Hans-Werner Vohr, Daniel J. Roberts, Pamela Weller, Azeddine Elhajouji, Yoshie Hiwata, Leon F. Stankowski, Joel Murray, Julia Kenny, Kentaro Tanaka
Publikováno v:
Environmental and Molecular Mutagenesis. 52:690-698
A collaborative international trial was conducted to evaluate the reproducibility and transferability of an in vivo mutation assay based on the enumeration of CD59-negative rat erythrocytes, a phenotype that is indicative of Pig-a gene mutation. Four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f313510d8a658754853218a9f4fc7a2
https://doi.org/10.1002/em.20672
https://doi.org/10.1002/em.20672
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 703:122-129
The aim of this study was to evaluate a modified flow cytometric method for the quantification of micronuclei in rat bone marrow reticulocytes. The method identified uses the erythrocyte pure fraction from cellulose filtered bone marrow with slight m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529447f976d0519f44eea1d55fe6681e
https://doi.org/10.1016/j.mrgentox.2010.08.006
https://doi.org/10.1016/j.mrgentox.2010.08.006
Autor:
William C, Gunther, Stephanie L, Coffing, Donna A, Dickinson, Maria E, Engel, Ronald D, Fiedler, Susan D, O'Lone, Kelley E, Sanok, Catherine J, Thiffeault, Thomas J, Shutsky, Maik J, Schuler, Krista L, Dobo
Publikováno v:
Environmental and molecular mutagenesis. 55(6)
Ethyl methanesulfonate (EMS) was evaluated as part of the validation effort for the rat Pig-a mutation assay and compared with other well-established in vivo genotoxicity endpoints. Male Sprague-Dawley (SD) rats were given a daily dose of 0, 6.25, 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f283fe0fbef317707abfa4b5e8cf0816
https://pubmed.ncbi.nlm.nih.gov/24599777
https://pubmed.ncbi.nlm.nih.gov/24599777
Autor:
Javed A. Bhalli, Maria Engel, Catherine J. Thiffeault, Ronald D. Fiedler, Mason G. Pearce, Zoryana Cammerer, Thomas J. Shutsky, Stephanie L. Coffing, Vasily N. Dobrovolsky, Xuefei Cao, Robert H. Heflich, William C. Gunther, Joseph G. Shaddock, Maik Schuler, Krista L. Dobo, Donna A. Dickinson
Publikováno v:
Environmental and molecular mutagenesis. 52(9)
N-Ethyl-N-nitrosourea (ENU) was evaluated as part of the Stage III trial for the rat Pig-a gene mutation assay. Groups of six- to eight-week-old male Sprague Dawley (SD) or Fischer 344 (F344) rats were given 28 daily doses of the phosphate buffered s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a99e0ee85a81564a9bc7d29a193ecb
https://pubmed.ncbi.nlm.nih.gov/22167886
https://pubmed.ncbi.nlm.nih.gov/22167886
Publikováno v:
Mutation research. 352(1-2)
The bacterial gyrase inhibitors, ciprofloxacin and PD 124816, were tested for clastogenic and aneugenic activity in V79 Chinese hamster lung cells in vitro. Cells were exposed for 3 h, washed free of drug, and subcultured for assessment of various en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f32fd70fba30108c80338c183540fb
https://pubmed.ncbi.nlm.nih.gov/8676903
https://pubmed.ncbi.nlm.nih.gov/8676903