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pro vyhledávání: '"Ronald Cepe Ramos"'
Autor:
Warren P. Mason, Ashley Adile, Eric Chen, Gelareh Zadeh, Ronald Cepe Ramos, Seth Andrew Climans, Stephanie Baker, Madeline Phillips, Pegah Ghiassi
Publikováno v:
Journal of Clinical Oncology. 39:e14026-e14026
e14026 Background: Isocitrate dehydrogenase (IDH) mutations are frequently observed in low grade gliomas and secondary glioblastoma. Mutant IDH enzymes aberrantly convert α-ketoglutarate (αKG) to 2-hydroxyglutarate (2HG). Accumulation of 2HG inhibi