Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Ronald C. Wek"'
Autor:
Michael J. Holmes, Matheus S. Bastos, Vishakha Dey, Vanessa Severo, Ronald C. Wek, William J. Sullivan
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT The protozoan parasite Toxoplasma gondii causes serious opportunistic disease due to its ability to persist in patients as latent tissue cysts. The molecular mechanisms coordinating conversion between proliferative parasites (tachyzoites) an
Externí odkaz:
https://doaj.org/article/a8cceeb976764713b579ecae1aea342e
Autor:
Leonardo Augusto, Jennifer Martynowicz, Parth H. Amin, Kenneth R. Carlson, Ronald C. Wek, William J. Sullivan
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Toxoplasma gondii
Externí odkaz:
https://doaj.org/article/535c051da52e490ca0480dd67306add6
Autor:
Leonardo Augusto, Jennifer Martynowicz, Parth H. Amin, Nada S. Alakhras, Mark H. Kaplan, Ronald C. Wek, William J. Sullivan
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT Toxoplasma gondii is an intracellular parasite that reconfigures its host cell to promote pathogenesis. One consequence of Toxoplasma parasitism is increased migratory activity of host cells, which facilitates dissemination. Here, we show th
Externí odkaz:
https://doaj.org/article/3d630c390fc84de5b6a66b41628efa5f
Autor:
Rana J. T. Al-Baghdadi, Inna A. Nikonorova, Emily T. Mirek, Yongping Wang, Jinhee Park, William J. Belden, Ronald C. Wek, Tracy G. Anthony
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The anti-leukemic agent asparaginase activates the integrated stress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1). The study objective was to investigate the protective role of acti
Externí odkaz:
https://doaj.org/article/8c386a86451643b7ab9901fa57812237
Publikováno v:
mSphere, Vol 4, Iss 3 (2019)
ABSTRACT Toxoplasma gondii is a ubiquitous obligate intracellular parasite that infects the nucleated cells of warm-blooded animals. From within the parasitophorous vacuole in which they reside, Toxoplasma tachyzoites secrete an arsenal of effector p
Externí odkaz:
https://doaj.org/article/66647780fabc4a5db5d2da1e3f7b81f0
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT Toxoplasma gondii is an intracellular parasite that has infected one-third of humans. The infection is permanent because the replicative form (tachyzoite) converts into a latent tissue cyst form (bradyzoite) that evades host immunity and is
Externí odkaz:
https://doaj.org/article/d35ccbb0218b4cf990eec818a552d435
Autor:
Mimi A. Trinh, Hanoch Kaphzan, Ronald C. Wek, Philippe Pierre, Douglas R. Cavener, Eric Klann
Publikováno v:
Cell Reports, Vol 1, Iss 6, Pp 676-688 (2012)
Translational control depends on phosphorylation of eIF2α by PKR-like ER kinase (PERK). To examine the role of PERK in cognitive function, we selectively disrupted PERK expression in the adult mouse forebrain. In the prefrontal cortex (PFC) of PERK-
Externí odkaz:
https://doaj.org/article/4072491586314068aff23161f4c9f3e0
Autor:
Erik A Koppes, Marie A Johnson, James J Moresco, Patrizia Luppi, Dale W Lewis, Donna B Stolz, Jolene K Diedrich, John R Yates, Ronald C Wek, Simon C Watkins, Susanne M Gollin, Hyun Jung Park, Peter Drain, Robert D Nicholls
Publikováno v:
PLoS Genetics, Vol 19, Iss 4, p e1010710 (2023)
Prader-Willi syndrome (PWS) is a multisystem disorder with neurobehavioral, metabolic, and hormonal phenotypes, caused by loss of expression of a paternally-expressed imprinted gene cluster. Prior evidence from a PWS mouse model identified abnormal p
Externí odkaz:
https://doaj.org/article/511e07a3ded143c49933e62d23762e4c
Autor:
Ricardo A Cordova, Jagannath Misra, Parth H Amin, Anglea J Klunk, Nur P Damayanti, Kenneth R Carlson, Andrew J Elmendorf, Hyeong-Geug Kim, Emily T Mirek, Bennet D Elzey, Marcus J Miller, X Charlie Dong, Liang Cheng, Tracy G Anthony, Roberto Pili, Ronald C Wek, Kirk A Staschke
Publikováno v:
eLife, Vol 11 (2022)
A stress adaptation pathway termed the integrated stress response has been suggested to be active in many cancers including prostate cancer (PCa). Here, we demonstrate that the eIF2 kinase GCN2 is required for sustained growth in androgen-sensitive a
Externí odkaz:
https://doaj.org/article/0e190e2bb8b949968cf1c2d48ee6413b
Autor:
Danni Jin, Sheree A. Wek, Ricardo A. Cordova, Ronald C. Wek, Didier Lacombe, Vincent Michaud, Karin Musier‐Forsyth
Publikováno v:
Clinical Genetics. 103:358-363
Aminoacyl-tRNA synthetases are enzymes that ensure accurate protein synthesis. Variants of the dual-functional cytoplasmic human glutamyl-prolyl-tRNA synthetase, EPRS1, have been associated with leukodystrophy, diabetes and bone disease. Here, we rep