Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ronald C. Griffith"'
Autor:
Louis R. Freedman, H. Steve White, Ranjit Ray, James C. Blosser, Sally A. McCreedy, Gene C. Palmer, George E. Garske, Ronald C. Griffith, Jose H. Woodhead, Eric W. Harris, Ewart A. Swinyard, Napier James J
Publikováno v:
Epilepsy Research. 9:161-174
Studies conducted by Fisons Pharmaceuticals and the Antiepileptic Drug Development Program (ADD Program) of the Epilepsy Branch (NINDS, NIH) revealed that ‘remacemide’ (FPL 12924, formerly PR 934-423) was effective orally in the prevention of max
Autor:
Gene C. Palmer, James J. Napiera, Mary L. Stagnitto, Jose H. Woodhead, H. Steve White, Robert J. Gentile, Ronald C. Griffith, Ewart A. Swinyard, J.Mark Ordy
Publikováno v:
Epilepsy Research. 8:36-48
Stereoisomers of remacemide (racemate form) were compared for anticonvulsant efficacy and safety in mice. In the maximal electroshock seizure (MES) test for oral efficacy, the (-) stereoisomer, FPL 14145, was more potent than the racemate or the (+)
Autor:
Mary L. Stagnitto, Jerry M. Frankenheim, H. Steve White, Gene C. Palmer, Ewart A. Swinyard, Robert J. Gentile, Jose H. Woodhead, Ronald C. Griffith, C.N. Becker, J.Mark Ordy, George E. Garske, Napier James J
Publikováno v:
Epilepsy Research. 7:11-28
Anticonvulsant tests in mice revealed specific, potent actions of remacemide for protection of mice against maximal electroshock seizures (MES). Comparisons of oral efficacy to reference compounds yielded the following ED50 values (expressed as mg/kg
Autor:
Ila, Sircar, Kristjan S, Gudmundsson, Richard, Martin, Jimmy, Liang, Sumihiro, Nomura, Honnappa, Jayakumar, Bradley R, Teegarden, Dawn M, Nowlin, Pina M, Cardarelli, Jason R, Mah, Samuel, Connell, Ronald C, Griffith, Elias, Lazarides
Publikováno v:
Bioorganicmedicinal chemistry. 10(6)
alpha(4)beta(1) and alpha(4)beta(7) integrins are key regulators of physiologic and pathologic responses in inflammation and autoimmune disease. The effectiveness of anti-integrin antibodies to attenuate a number of inflammatory/immune conditions pro
Autor:
Ronald C. Griffith, Robert J. Murray, George B. Mullen, Anthony C. Machulskis, Sally A. McCreedy, James C. Blosser, Edwin S. C. Wu, James T. Loch, Alex Kover
Publikováno v:
Journal of medicinal chemistry. 38(9)
The cholinergic hypothesis of Alzheimer's disease suggests that cholinergic agonists may have therapeutic potential for treating the attendant memory deficits of the disease. As part of a program aimed at preparing metabolically stable, nonquaternary
Autor:
James J. Napier, George E. Garske, Metro Fedorchuk, Robert J. Murray, Ronald C. Griffith, Ranjit Ray, Mark S. Eisman, Mary L. Stagnitto, Theresa C.M. Wilson, Gene C. Palmer
Publikováno v:
Epilepsy research. 12(1)
Remacemide hydrochloride ((±)-2-amino-N-(1-methyl-1,2-diphenylethyl)-acetamide hydrochloride or FPL 12924AA) is a novel compound undergoing clinical trials for patients with generalized tonic/clonic and complex partial epilepsy. Remacemide exhibits
Publikováno v:
Tetrahedron Letters. 17:1465-1468
Publikováno v:
The Journal of Organic Chemistry. 44:3580-3583
Publikováno v:
The Journal of Organic Chemistry. 40:3726-3729
High-resolution ^(13)C pulse Fourier transform nuclear magnetic resonance has been used to study the effects of charge-transfer complexation between trinitrobenzene and aromatic donor molecules: benzene, mesitylene, naphthalene, and anthracene. Plots
Publikováno v:
Journal of Medicinal Chemistry. 27:995-1003
Molecular modelling studies suggested the synthesis of cis-1,3,4,6,7, 11b-hexahydro-2-methyl-7-phenyl-2H-pyrazino[2,1-a]isoquinoline (7a) as a rigid analogue of the atypical antidepressant mianserin. Acylation of 2,2-diphenylethylamine with chloroace