Zobrazeno 1 - 10
of 261
pro vyhledávání: '"Ronald C Montelaro"'
Autor:
Jodi K Craigo, Corin Ezzelarab, Sheila J Cook, Chong Liu, David Horohov, Charles J Issel, Ronald C Montelaro
Publikováno v:
PLoS Pathogens, Vol 11, Iss 1, p e1004610 (2015)
Lentiviral Envelope (Env) antigenic variation and related immune evasion present major hurdles to effective vaccine development. Centralized Env immunogens that minimize the genetic distance between vaccine proteins and circulating viral isolates are
Externí odkaz:
https://doaj.org/article/ad2b2be5aff544ec8d3ccfbd59af18a6
Publikováno v:
F1000Research, Vol 2 (2013)
Background: Host-derived (LL-37) and synthetic (WLBU-2) cationic antimicrobial peptides (CAPs) are known for their membrane-active bactericidal properties. LL-37 is an important mediator for immunomodulation, while the mechanism of action of WLBU-2 r
Externí odkaz:
https://doaj.org/article/33181c6d9f21485ea1fb5e6a4813914d
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e65220 (2013)
Substantial controversy surrounds the membrane topology of the HIV-1 gp41 C-terminal tail (CTT). While few studies have been designed to directly address the topology of the CTT, results from envelope (Env) protein trafficking studies suggest that th
Externí odkaz:
https://doaj.org/article/56d9ff26693b462c8894ac7bca53cfbb
Autor:
Jodi K Craigo, Corin Ezzelarab, Sheila J Cook, Liu Chong, David Horohov, Charles J Issel, Ronald C Montelaro
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66093 (2013)
Lentiviral envelope (Env) antigenic variation and associated immune evasion present major obstacles to vaccine development. The concept that Env is a critical determinant for vaccine efficacy is well accepted, however defined correlates of protection
Externí odkaz:
https://doaj.org/article/80877b18412448dc8b050d12a9fbc57d
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32539 (2012)
Although there are different strains of HIV-1 in a chronically infected individual, only one or limited virus strains are successfully transmitted to a new individual. The reason for this "transmission bottleneck" is as yet unknown.A human cervical e
Externí odkaz:
https://doaj.org/article/d467656964bc4d9d9875673d89cd3e1c
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15261 (2010)
The C-terminal tail (CTT) of the HIV-1 gp41 envelope (Env) protein is increasingly recognized as an important determinant of Env structure and functional properties, including fusogenicity and antigenicity. While the CTT has been commonly referred to
Externí odkaz:
https://doaj.org/article/0bce9e6f090e4255831e611876b2136e
Autor:
Collin R Diedrich, Joshua T Mattila, Edwin Klein, Chris Janssen, Jiayao Phuah, Timothy J Sturgeon, Ronald C Montelaro, Philana Ling Lin, Joanne L Flynn
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9611 (2010)
HIV-infected individuals with latent Mycobacterium tuberculosis (Mtb) infection are at significantly greater risk of reactivation tuberculosis (TB) than HIV-negative individuals with latent TB, even while CD4 T cell numbers are well preserved. Factor
Externí odkaz:
https://doaj.org/article/0ecd581b9015435bbfbecc3cd9e8b29f
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6551 (2009)
Retroviral Gag polyproteins are necessary and sufficient for virus budding. Productive HIV-1 Gag assembly takes place at the plasma membrane. However, little is known about the mechanisms by which thousands of Gag molecules are targeted to the plasma
Externí odkaz:
https://doaj.org/article/16867a239da1467ea7634b34c77bc12d
Publikováno v:
Pharmaceutics, Vol 12, Iss 6, p 501 (2020)
The increasing rate of antibiotic resistance constitutes a global health crisis. Antimicrobial peptides (AMPs) have the property to selectively kill bacteria regardless of resistance to traditional antibiotics. However, several challenges (e.g., redu
Externí odkaz:
https://doaj.org/article/22c468f2a1e74d199282d4c5b4fa6739
Autor:
Ronald C. Montelaro, Jan H. Beumer, Julie L. Eiseman, Berthony Deslouches, Jianxia Guo, Jonathan D. Steckbeck, Robert A. Parise, Evan C. Ray, Jonas Scemama
Publikováno v:
Curr Rev Clin Exp Pharmacol
Background: To address multidrug resistance, we developed engineered Cationic Antimicrobial Peptides (eCAPs). Lead eCAP WLBU2 displays potent activity against drug-resistant bacteria and effectively treats lethal bacterial infections in mice, reducin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971296bd3979f7e32e268ce243fcacdf
https://doi.org/10.2174/1574884715666200810094201
https://doi.org/10.2174/1574884715666200810094201