Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ronald Breaker"'
Autor:
Michael Mohsen, Ronald Breaker
Publikováno v:
Bio-Protocol, Vol 13, Iss 13 (2023)
Engineered aptamers for new compounds are typically produced by using in vitro selection methods. However, aptamers that are developed in vitro might not function as expected when introduced into complex cellular environments. One approach that addre
Externí odkaz:
https://doaj.org/article/dcbb3fd7ad8b423da7312d20af403ced
Autor:
Zizhen Yao, Jeffrey Barrick, Zasha Weinberg, Shane Neph, Ronald Breaker, Martin Tompa, Walter L Ruzzo
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 7, p e126 (2007)
Noncoding RNAs (ncRNAs) are important functional RNAs that do not code for proteins. We present a highly efficient computational pipeline for discovering cis-regulatory ncRNA motifs de novo. The pipeline differs from previous methods in that it is st
Externí odkaz:
https://doaj.org/article/b23bdf9e4ba245169c20fb881430c0e0
Autor:
Ronald Breaker
Publikováno v:
Biochemistry. 61:137-149
More than 55 distinct classes of riboswitches that respond to small metabolites or elemental ions have been experimentally validated to date. The ligands sensed by these riboswitches are biased in favor of fundamental compounds or ions that are likel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e20e04f700d82fc6772cfe59f18b96
https://doi.org/10.1021/acs.biochem.1c00765
https://doi.org/10.1021/acs.biochem.1c00765
Autor:
Ronald Breaker
Publikováno v:
ACS Chem Biol
Biocatalysis is dominated by protein enzymes, and only a few classes of ribozymes are known to contribute to the task of promoting biochemical transformations. The RNA World theory encompasses the notion that earlier forms of life made use of a much
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463e657339db264a1d619864ae9903c5
https://doi.org/10.1021/acschembio.0c00214
https://doi.org/10.1021/acschembio.0c00214
Publikováno v:
Journal of Biological Chemistry. 299:104221
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6b1979a8443d0167b2755d9aee15b01
https://doi.org/10.1016/j.jbc.2023.104221
https://doi.org/10.1016/j.jbc.2023.104221
Autor:
Sarah Malkowski, João Trindade Marques, Christina E. Weinberg, née Lünse, Ronald Breaker, Etienne Greenlee, Ruben Atilho, Eric Aguiar
Publikováno v:
RNA
The Fibro-purF motif is a putative structured noncoding RNA domain that was discovered previously in species of Fibrobacter by using comparative sequence analysis methods. An updated bioinformatics search yielded a total of only 30 unique-sequence re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22cb1d7394410a9e07449f09453449d
https://europepmc.org/articles/PMC7668255/
https://europepmc.org/articles/PMC7668255/
Publikováno v:
BioTechniques. 54:337-343
DNA molecules that encode a small, high-speed self-hydrolyzing deoxyribozyme are used as templates for rolling circle amplification (RCA) to produce single-stranded DNAs (ssDNAs) of single- and multiple-unit lengths. Including self-cleaving deoxyribo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2c9e79e7be952232057ff785e68c05
https://doi.org/10.2144/000114009
https://doi.org/10.2144/000114009
Autor:
Ronald Breaker
Publikováno v:
Science. 319:1795-1797
Using simple biochemical tricks, metabolite-binding riboswitches take on gene control functions that have long been thought to be the work of protein factors. Although modern riboswitches might be the last holdouts of primitive genetic elements, some
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4eebe484362a393f8892d5fee11cc9
https://doi.org/10.1126/science.1152621
https://doi.org/10.1126/science.1152621
Autor:
Ronald Breaker
Publikováno v:
Nature biotechnology. 15(5)
Biological catalysis is dominated by enzymes that are made of protein, but several distinct classes of catalytic RNAs are known to promote chemical transformations that are fundamental to cellular metabolism. Is biological catalysis limited only to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df810a2d3cad1063670940e202a1ca20
https://pubmed.ncbi.nlm.nih.gov/9131619
https://pubmed.ncbi.nlm.nih.gov/9131619
Autor:
Ronald Breaker
Publikováno v:
Trends in Biotechnology. 16:52-53
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30d83809f366df8ea628fb2d653035ad
https://doi.org/10.1016/s0167-7799(98)01131-7
https://doi.org/10.1016/s0167-7799(98)01131-7