Differential DNA methylation of vocal and facial anatomy genes in modern humans

Autor: David Gokhman, Malka Nissim-Rafinia, Lily Agranat-Tamir, Genevieve Housman, Raquel García-Pérez, Esther Lizano, Olivia Cheronet, Swapan Mallick, Maria A. Nieves-Colón, Heng Li, Songül Alpaslan-Roodenberg, Mario Novak, Hongcang Gu, Jason M. Osinski, Manuel Ferrando-Bernal, Pere Gelabert, Iddi Lipende, Deus Mjungu, Ivanela Kondova, Ronald Bontrop, Ottmar Kullmer, Gerhard Weber, Tal Shahar, Mona Dvir-Ginzberg, Marina Faerman, Ellen E. Quillen, Alexander Meissner, Yonatan Lahav, Leonid Kandel, Meir Liebergall, María E. Prada, Julio M. Vidal, Richard M. Gronostajski, Anne C. Stone, Benjamin Yakir, Carles Lalueza-Fox, Ron Pinhasi, David Reich, Tomas Marques-Bonet, Eran Meshorer, Liran Carmel

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)

How traits specific to modern humans have evolved is difficult to study. Here, Gokhman et al. compare measured and reconstructed DNA methylation maps of present-day humans, archaic humans and chimpanzees and find that genes that affect vocal tract an

Externí odkaz: https://doaj.org/article/f72a64784f804644b521ad8a4ae77ab7

Human Oocyte-Derived Methylation Differences Persist in the Placenta Revealing Widespread Transient Imprinting.

Autor: Marta Sanchez-Delgado, Franck Court, Enrique Vidal, Jose Medrano, Ana Monteagudo-Sánchez, Alex Martin-Trujillo, Chiharu Tayama, Isabel Iglesias-Platas, Ivanela Kondova, Ronald Bontrop, Maria Eugenia Poo-Llanillo, Tomas Marques-Bonet, Kazuhiko Nakabayashi, Carlos Simón, David Monk

Publikováno v: PLoS Genetics, Vol 12, Iss 11, p e1006427 (2016)

Thousands of regions in gametes have opposing methylation profiles that are largely resolved during the post-fertilization epigenetic reprogramming. However some specific sequences associated with imprinted loci survive this demethylation process. He

Externí odkaz: https://doaj.org/article/0e4b89b8a6004bec95c52f9a1c7cafd9

Origins of De Novo Genes in Human and Chimpanzee.

Autor: Jorge Ruiz-Orera, Jessica Hernandez-Rodriguez, Cristina Chiva, Eduard Sabidó, Ivanela Kondova, Ronald Bontrop, Tomàs Marqués-Bonet, M Mar Albà

Publikováno v: PLoS Genetics, Vol 11, Iss 12, p e1005721 (2015)

The birth of new genes is an important motor of evolutionary innovation. Whereas many new genes arise by gene duplication, others originate at genomic regions that did not contain any genes or gene copies. Some of these newly expressed genes may acqu

Externí odkaz: https://doaj.org/article/b37e05c0001944ad9e2d1be6d3974105

Extreme selective sweeps independently targeted the X chromosomes of the great apes

Autor: Marta Mele, Irene Herreaz, Timothy O'Connor, Carlos D. Bustamante, Aurora Ruiz-Herrera, Ivo Gut, Christina Hvilsom, Tomas Marques-Bonet, Mikkel Heide Schierup, Jessica Hernandez-Rodriguez, Laurie Stevison, Simon Myers, Kasper Munch, Ronald Bontrop, Michael Wilson, Kiwoong Nam, Aida Andres, Anne Pusey, Marc Pybus, Asger Hobolth, Javier Prado-Martinez, Mario Ventura, Joshua Akey

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 112, iss 20
Proceedings of the National Academy of Sciences of the United States of America 20 (112), 6413-6418. (2015)
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (20), pp.6413-6418. ⟨10.1073/pnas.1419306112⟩
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (20), pp.6413-6418. ⟨10.1073/pnas.1419306112⟩
Europe PubMed Central
Nam, K, Munch, K, Hobolth, A, Dutheil, J Y, Veeramah, K R, Woerner, A E, Hammer, M F, Mailund, T, Schierup, M H & Great Ape Genome Diversity Project 2015, ' Extreme selective sweeps independently targeted the X chromosomes of the great apes ', Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 20 . https://doi.org/10.1073/pnas.1419306112

International audience; The unique inheritance pattern of the X chromosome exposes it to natural selection in a way that is different from that of the autosomes, potentially resulting in accelerated evolution. We perform a comparative analysis of X c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31287355910179886e93be4dc3ec9d02
https://escholarship.org/uc/item/82b7b5d6

Patent report

Autor: Walter Bodmer, Ronald Bontrop

Publikováno v: Human Immunology. 60:361-395

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86cc46c7b7b038dadba80b16bdb7290a
https://doi.org/10.1016/s0198-8859(99)00042-7