Výsledky vyhledávání - "Ronald B DeMattos"

Akademický článek

Amyloid-β (Aβ) immunotherapy induced microhemorrhages are linked to vascular inflammation and cerebrovascular damage in a mouse model of Alzheimer’s disease

Autor: Xavier Taylor, Harun N. Noristani, Griffin J. Fitzgerald, Herold Oluoch, Nick Babb, Tyler McGathey, Lindsay Carter, Justin T. Hole, Pascale N. Lacor, Ronald B. DeMattos, Yaming Wang

Publikováno v: Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-16 (2024)

Abstract Background Anti-amyloid-β (Aβ) immunotherapy trials have revealed amyloid-related imaging abnormalities (ARIA) as the most prevalent and serious adverse events linked to pathological changes in cerebral vasculature. Recent studies undersco

Externí odkaz: https://doaj.org/article/8fe976e4e14749c59a9eec8996d28a36

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Akademický článek

Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice

Autor: Xavier Taylor, Isaiah M. Clark, Griffin J. Fitzgerald, Herold Oluoch, Justin T. Hole, Ronald B. DeMattos, Yaming Wang, Feng Pan

Publikováno v: Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-16 (2023)

Abstract Background Amyloid-related imaging abnormalities (ARIA) have been identified as the most common and serious adverse events resulting from pathological changes in the cerebral vasculature during several recent anti-amyloid-β (Aβ) immunother

Externí odkaz: https://doaj.org/article/92504fa84574440fa1b3fbeddb47ce41

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Akademický článek

Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model

Publikováno v: Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-19 (2018)

Abstract Background Activation of microglia, the resident immune cells of the central nervous system, is a prominent pathological hallmark of Alzheimer’s disease (AD). However, the gene expression changes underlying microglia activation in response

Externí odkaz: https://doaj.org/article/96f83b1cdfe5461fbb9ab739a9f3c4f2

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Akademický článek

Advancing combination therapy for Alzheimer's disease

Autor: Stephen P. Salloway, Jeff Sevingy, Kumar Budur, Jan Torleif Pederson, Ronald B. DeMattos, Philipp Von Rosenstiel, Antonio Paez, Rebecca Evans, Christopher J. Weber, James A. Hendrix, Susan Worley, Lisa J. Bain, Maria C. Carrillo

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)

Abstract The study of Alzheimer's disease (AD) has led to an increased understanding of the multiple pathologies and pathways of the disease. As such, it has been proposed that AD and its various stages might be most effectively treated with a combin

Externí odkaz: https://doaj.org/article/28b75d0afd1f436897e12b900a8ab760

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