Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Ronald Allan M. Panganiban"'
Autor:
Ronald Allan M. Panganiban, Zhiping Yang, Maoyun Sun, Chan Young Park, David I. Kasahara, Niccole Schaible, Ramaswamy Krishnan, Alvin T. Kho, Elliot Israel, Marc B. Hershenson, Scott T. Weiss, Blanca E. Himes, Jeffrey J. Fredberg, Kelan G. Tantisira, Stephanie A. Shore, Quan Lu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
The underlying mechanisms of how obesity increases asthma prevalence and severity are not well understood. Here, the authors show that antagonizing cholecystokinin and its receptor, CCKAR, in the lung attenuates obesity-associated airway hyperrespons
Externí odkaz:
https://doaj.org/article/627590137e8e4854b2f7c749238e36dd
Autor:
Alvin T. Kho, Michael J. McGeachie, Ronald Allan M Panganiban, Scott T. Weiss, Jiang Li, Leanna Farnam, Quan Lu, Kelan G. Tantisira, Robert P. Chase
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 202:65-72
Rationale: Inhaled corticosteroids (ICS) are key treatments for controlling asthma and preventing asthma attacks. However, the responsiveness to ICS varies among individuals. MicroRNAs (miRNAs) hav...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8dfc59835351a2a74af2670c9fcb879
https://doi.org/10.1164/rccm.201907-1454oc
https://doi.org/10.1164/rccm.201907-1454oc
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Arsenic (As) exposure adversely affects neurodevelopment in children. Accumulation of misfolded proteins in cells exposed to As leads to endoplasmic reticulum (ER) stress response, which, if not relieved, results in cell death. Despite the potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd77e95218169332c030bcae9b4214c
https://doaj.org/article/5b5fa3571846481a828594723012b8be
https://doaj.org/article/5b5fa3571846481a828594723012b8be
Autor:
William O.C.M. Cookson, Wonil Chung, Lu Qi, Blanca E. Himes, Zhaozhong Zhu, Carlos A. Camargo, Cong-Lin Liu, Quan Lu, Kohei Hasegawa, Frank B. Hu, Miriam F. Moffatt, Liming Liang, Huwenbo Shi, Ronald Allan M Panganiban, Luke J. O’Connor, Steven Gazal, Yanjun Guo
Publikováno v:
Journal of Allergy and Clinical Immunology. 145:537-549
Background Clinical and epidemiologic studies have shown that obesity is associated with asthma and that these associations differ by asthma subtype. Little is known about the shared genetic components between obesity and asthma. Objective We sought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa216a77c6c387b79a68ff4488b4f73f
https://doi.org/10.1016/j.jaci.2019.09.035
https://doi.org/10.1016/j.jaci.2019.09.035
Autor:
Ann Chen Wu, Quan Lu, Esteban G. Burchard, Amber Dahlin, Max A. Seibold, Kelan G. Tantisira, Alberta L. Wang, Sam S. Oh, Michael J. McGeachie, Alvin T. Kho, Ronald Allan M Panganiban, Rachel S. Kelly, Sharon M. Lutz, Celeste Eng, Joanne E. Sordillo, Jose R. Rodriguez-Santana, B. Saef, Angel C.Y. Mak, Damien C. Croteau-Chonka, Satria Sajuthi, Benjamin A. Raby, Cydney Urbanek, Scott T. Weiss
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-8 (2020)
Respiratory research, vol 21, iss 1
Respiratory Research
Respiratory research, vol 21, iss 1
Respiratory Research
Background Global gene expression levels are known to be highly dependent upon gross demographic features including age, yet identification of age-related genomic indicators has yet to be comprehensively undertaken in a disease and treatment-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d13fb6535f919686bee5c972880004f
https://doaj.org/article/fffacd0e6d1c4c46ad483388a089547f
https://doaj.org/article/fffacd0e6d1c4c46ad483388a089547f
Autor:
Gabrielle Webb, Joseph P. Allen, Blanca E. Himes, Michael O'Sullivan, Jose Vallarino, David C. Christiani, Maya Shumyatcher, Hae-Ryung Park, Charlotte Wirth, Ronald Allan M Panganiban, Jin-Ah Park, Quan Lu
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
The widespread use of electronic cigarettes (e-cig) is a serious public health concern; however, mechanisms by which e-cig impair the function of airway epithelial cells—the direct target of e-cig smoke—are not fully understood. Here we report tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13e5d9556eb0ea90f892ced95e3eb79
https://doi.org/10.1038/s41598-021-97013-z
https://doi.org/10.1038/s41598-021-97013-z
Autor:
Ronald Allan M, Panganiban, Zhiping, Yang, Maoyun, Sun, Chan Young, Park, David I, Kasahara, Niccole, Schaible, Ramaswamy, Krishnan, Alvin T, Kho, Elliot, Israel, Marc B, Hershenson, Scott T, Weiss, Blanca E, Himes, Jeffrey J, Fredberg, Kelan G, Tantisira, Stephanie A, Shore, Quan, Lu
Publikováno v:
Nature communications. 14(1)
Obesity increases asthma prevalence and severity. However, the underlying mechanisms are poorly understood, and consequently, therapeutic options for asthma patients with obesity remain limited. Here we report that cholecystokinin-a metabolic hormone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::716f984ceea845e45c2a23e6bec029a6
https://pubmed.ncbi.nlm.nih.gov/36599824
https://pubmed.ncbi.nlm.nih.gov/36599824
Autor:
Maoyun Sun, Blanca E. Himes, Maya Shumyatcher, Quan Lu, Ronald Allan M Panganiban, Hae-Ryung Park
Publikováno v:
Proceedings of the National Academy of Sciences. 116:13384-13393
Sensing misfolded proteins in the endoplasmic reticulum (ER), cells initiate the ER stress response and, when overwhelmed, undergo apoptosis. However, little is known about how cells prevent excessive ER stress response and cell death to restore home
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2cf410ab2a9a3659d67804f317a9995
https://doi.org/10.1073/pnas.1906275116
https://doi.org/10.1073/pnas.1906275116
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/65446303952d4f81b22bd93738192406