Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Ronald A. Seifert"'
Publikováno v:
Journal of Biological Chemistry. 285:10487-10496
Phogrin is a transmembrane protein expressed in cells with stimulus-coupled peptide hormone secretion, including pancreatic beta cells, in which it is localized to the membrane of insulin-containing dense-core vesicles. By sequence, phogrin is a memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f76c5a41a5031081249e8d644b6381
https://doi.org/10.1074/jbc.m109.066563
https://doi.org/10.1074/jbc.m109.066563
Autor:
Friedemann J. Schaub, Kirsten Sayson, Nicola Ferri, Ronald A. Seifert, W. Conrad Liles, Daniel F. Bowen-Pope
Publikováno v:
Circulation Research. 93:515-522
We previously reported that treatment of human vascular smooth muscle cells (SMCs) with proapoptotic stimuli, including Fas ligand plus cycloheximide (FasL/Chx), or overexpression of Fas-associated death domain protein (FADD) result in increased expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ad038e31329007336a1137e582166a
https://doi.org/10.1161/01.res.0000093205.42313.7c
https://doi.org/10.1161/01.res.0000093205.42313.7c
Autor:
Daniel F. Bowen-Pope, Jeffrey R. Crosby, Ronald A. Seifert, Bernard S. Buetow, Kristen A. Tappan
Publikováno v:
The American Journal of Pathology. 163:979-984
The carotid artery shows a common response to many forms of injury, including a rapid activation of smooth muscle cell (SMC) proliferation in the media and migration of SMCs into the intima to form a neointima. Platelet-derived growth factor (PDGF) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca672703efb8f2dcd901f3e8af38becb
https://doi.org/10.1016/s0002-9440(10)63457-8
https://doi.org/10.1016/s0002-9440(10)63457-8
Autor:
Ronald A. Seifert, Bernard S. Buetow, Wolfgang E. Kaminski, Jeffrey R. Crosby, Paul J. Martin, Elaine W. Raines, Daniel F. Bowen-Pope, Ravi K. Ramachandran, Per Lindahl, Christer Betsholtz
Publikováno v:
The American Journal of Pathology. 159:1869-1876
The hypothesis that wound repair is augmented by delivery of platelet-derived growth factor (PDGF) from platelets and macrophages is an attractive extrapolation from the known activities of PDGF in cell culture and in vivo. To test this hypothesis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305c6c10f1406de02d8f02d1f53efbd0
https://doi.org/10.1016/s0002-9440(10)63033-7
https://doi.org/10.1016/s0002-9440(10)63033-7
Autor:
Richard D. Kenagy, David Hasenstab, Ronald A. Seifert, David P. Mason, Suzanne Hawkins, Scott A. Coats, Alexander W. Clowes, Daniel F. Bowen-Pope
Publikováno v:
Circulation Research. 85:1179-1185
Abstract —Matrix metalloproteinase-9 (MMP-9) has been implicated in the pathogenesis of atherosclerosis as well as intimal hyperplasia after vascular injury. We used Fischer rat smooth muscle cells (SMCs) overexpressing MMP-9 to determine the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b9035922c560c9d21c187aee1e0d0c
https://doi.org/10.1161/01.res.85.12.1179
https://doi.org/10.1161/01.res.85.12.1179
Publikováno v:
Experimental Cell Research. 247:257-266
The product of the Wilm's tumor suppressor gene, WT1, is a zinc-finger DNA-binding protein, which is thought to be a transcription factor. Two genes, those encoding epidermal growth factor receptor and syndecan-1, are known to be endogenous targets o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb94e098789a94a61881393fdd630ae0
https://doi.org/10.1006/excr.1998.4361
https://doi.org/10.1006/excr.1998.4361
Publikováno v:
Nature Genetics. 18:385-388
Blood vessels originate as simple endothelial cell tubes. It has been proposed that platelet-derived growth factor B polypeptide (Pdgfb) secreted by these endothelial cells drives the formation of the surrounding muscular wall by recruiting nearby me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d73ae739bd33457ba0c180db3b4629
https://doi.org/10.1038/ng0498-385
https://doi.org/10.1038/ng0498-385
Publikováno v:
Journal of Cellular Physiology. 169:126-138
Immunocytochemical data has indicated that platelet-derived growth factor receptor beta-subunit (PDGFR beta) expression by connective tissue cells is up-regulated in many disease states. To investigate potential causes of this up-regulation, we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a45cd49470cd6379cafc2832050142f
https://doi.org/10.1002/(sici)1097-4652(199610)169:1<126::aid-jcp13>3.0.co
https://doi.org/10.1002/(sici)1097-4652(199610)169:1<126::aid-jcp13>3.0.co
Publikováno v:
Journal of Biological Chemistry. 269:13951-13955
Mitogenic stimulation of connective tissue cells by transforming growth factor-beta (TGF-beta) has two unusual properties; entry into S-phase is delayed compared with that induced by other mitogens, and the dose response is biphasic, with low concent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16b93dcb8f948eaf30c153b84a89846a
https://doi.org/10.1016/s0021-9258(17)36740-6
https://doi.org/10.1016/s0021-9258(17)36740-6
Autor:
Larry W. Kraiss, Thomas B. Barrett, Alexander W. Clowes, Charles E. Hart, Russell Ross, Daniel F. Bowen-Pope, Ronald A. Seifert, Josiah N. Wilcox, Elaine W. Raines, Thomas R. Kirkman
Publikováno v:
Journal of Clinical Investigation. 92:338-348
Healing baboon polytetrafluoroethylene grafts express PDGF mRNA in the neointima. Perfusates of graft segments also contain PDGF-like mitogenic activity. To extend these findings, we studied the expression and regional distribution of the PDGF protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8728f7fe1f52372d8e0261f1f637a926
https://doi.org/10.1172/jci116572
https://doi.org/10.1172/jci116572