Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Ronald A Merrill"'
Publikováno v:
eLife, Vol 4 (2015)
While the dynamin GTPase Drp1 plays a critical role during mitochondrial fission, mechanisms controlling its recruitment to fission sites are unclear. A current assumption is that cytosolic Drp1 is recruited directly to fission sites immediately prio
Externí odkaz:
https://doaj.org/article/386eba9dcc3c4ce5a95a25e7c2a96bd0
Autor:
Deng-Fu Guo, Ronald A. Merrill, Lan Qian, Ying Hsu, Qihong Zhang, Zhihong Lin, Daniel R. Thedens, Yuriy M. Usachev, Isabella Grumbach, Val C. Sheffield, Stefan Strack, Kamal Rahmouni
Publikováno v:
Molecular Metabolism, Vol 90, Iss , Pp 102038- (2024)
Externí odkaz:
https://doaj.org/article/a5863d78d79f4d7793bc4c8b5114c71c
Autor:
Ronald A Merrill, Ruben K Dagda, Audrey S Dickey, J Thomas Cribbs, Steven H Green, Yuriy M Usachev, Stefan Strack
Publikováno v:
PLoS Biology, Vol 9, Iss 4, p e1000612 (2011)
Mitochondrial shape is determined by fission and fusion reactions catalyzed by large GTPases of the dynamin family, mutation of which can cause neurological dysfunction. While fission-inducing protein phosphatases have been identified, the identity o
Externí odkaz:
https://doaj.org/article/9416d933b26d4774ad931fda500fafb0
Autor:
Steven Findlay, Remya Nair, Ronald A Merrill, Zafir Kaiser, Alexandre Cajelot, Zahra Aryanpour, John Heath, Catherine St-Louis, David Papadopoli, Ivan Topisirovic, Julie St-Pierre, Michael Sebag, Aparna H Kesarwala, Laura Hulea, Eric B Taylor, Mala Shanmugam, Alexandre Orthwein
Publikováno v:
Blood Advances.
Multiple myeloma (MM) is a hematological malignancy that emerges from antibody-producing plasma B cells. Proteasome inhibitors, including the FDA-approved bortezomib (BTZ) and carfilzomib (CFZ), are frequently used for the treatment of MM patients. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92ee2781719047fd98f2fe44115ad74b
https://doi.org/10.1182/bloodadvances.2022008345
https://doi.org/10.1182/bloodadvances.2022008345
Autor:
Cheng-Guo Wu, Vijaya K. Balakrishnan, Pankaj S. Parihar, Kirill Konovolov, Yu-Chia Chen, Ronald A Merrill, Hui Wei, Bridget Carragher, Ramya Sundaresan, Qiang Cui, Brian E. Wadzinski, Mark R. Swingle, Alla Musiyenko, Richard Honkanen, Wendy K. Chung, Aussie Suzuki, Stefan Strack, Xuhui Huang, Yongna Xing
An increasing number of mutations associated with devastating human diseases are diagnosed by whole-genome/exon sequencing. Recurrentde novomissense mutations have been discovered in B56δ (encoded byPPP2R5D), a regulatory subunit of protein phosphat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8c7723ac5bfc49c8706fa023d5ad09e
https://doi.org/10.1101/2023.03.09.530109
https://doi.org/10.1101/2023.03.09.530109
Publikováno v:
Cells, Vol 9, Iss 2, p 298 (2020)
Best known as the powerhouse of the cell, mitochondria have many other important functions such as buffering intracellular calcium and reactive oxygen species levels, initiating apoptosis and supporting cell proliferation and survival. Mitochondria a
Externí odkaz:
https://doaj.org/article/bf2f25dbf62c4fe08b5ce7640a5d6817
Autor:
Deng-Fu Guo, Ronald A. Merrill, Lan Qian, Ying Hsu, Qihong Zhang, Zhihong Lin, Daniel R. Thedens, Yuriy M. Usachev, Isabella Grumbach, Val C. Sheffield, Stefan Strack, Kamal Rahmouni
Publikováno v:
Molecular metabolism. 67
The essential role of mitochondria in regulation of metabolic function and other physiological processes has garnered enormous interest in understanding the mechanisms controlling the function of this organelle. We assessed the role of the BBSome, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d682ab26d289b2f2771deb2421fc16
https://pubmed.ncbi.nlm.nih.gov/36513220
https://pubmed.ncbi.nlm.nih.gov/36513220
Publikováno v:
Hypertension. 79
Mitochondria are best known as the powerhouse of the cell playing a critical role in energy metabolism with important implications in the development of obesity, a major cause of type 2 diabetes and hypertension. A-kinase anchoring protein 1 (AKAP1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8a98d8ca44079fbe41cc6cd019839e5
https://doi.org/10.1161/hyp.79.suppl_1.109
https://doi.org/10.1161/hyp.79.suppl_1.109
Autor:
Lee M. Graves, Emily M. Wilkerson, Ronald A. Merrill, Chian Ju Jong, Laura E. Herring, Stefan Strack
Publikováno v:
J Biol Chem
Protein phosphatase 2A (PP2A) is a large enzyme family responsible for most cellular Ser/Thr dephosphorylation events. PP2A substrate specificity, localization, and regulation by second messengers rely on more than a dozen regulatory subunits (includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588998eae06a06e2c15af82aa1b52b94
https://doi.org/10.1074/jbc.ra119.011270
https://doi.org/10.1074/jbc.ra119.011270
Publikováno v:
J Cell Sci
Neurodevelopmental disorders (NDDs), including intellectual disability (ID), autism and schizophrenia, have high socioeconomic impact, yet poorly understood etiologies. A recent surge of large-scale genome or exome sequencing studies has identified a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e18afabae66aa4f954c044ffa1eeee
https://doi.org/10.1242/jcs.248187
https://doi.org/10.1242/jcs.248187