Zobrazeno 1 - 10
of 468
pro vyhledávání: '"Ronald A Lubet"'
Autor:
David L McCormick, Thomas L Horn, William D Johnson, Xinjian Peng, Ronald A Lubet, Vernon E Steele
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141849 (2015)
Peroxisome-proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor that regulates cell proliferation, differentiation, and apoptosis. In vivo studies were performed to evaluate the activities of two thiazolidinedione PP
Externí odkaz:
https://doaj.org/article/56ce08f91b1a421f9bdca714484e37aa
Autor:
Haitao Li, Feng Zhu, Yanwen Sun, Bing Li, Naomi Oi, Hanyong Chen, Ronald A Lubet, Ann M Bode, Zigang Dong
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76452 (2013)
Recent clinical trials raised concerns regarding the cardiovascular toxicity of selective cyclooxygenase-2 (COX-2) inhibitors. Many active dietary factors are reported to suppress carcinogenesis by targeting COX-2. A major question was accordingly ra
Externí odkaz:
https://doaj.org/article/e5ae3c7251064df2997bdbc8a1fa9fbe
Autor:
Kooresh I Shoghi, Jinbin Xu, Yi Su, June He, Douglas Rowland, Ying Yan, Joel R Garbow, Zhude Tu, Lynne A Jones, Ryuji Higashikubo, Kenneth T Wheeler, Ronald A Lubet, Robert H Mach, Ming You
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74188 (2013)
The sigma-2 receptor is expressed in higher density in proliferating (P) tumor cells versus quiescent (Q) tumor cells, thus providing an attractive target for imaging the proliferative status (i.e., P:Q ratio) of solid tumors. Here we evaluate the ut
Externí odkaz:
https://doaj.org/article/c5a3854f8bff403898b8262dcd16b9ea
Autor:
Hanyong Chen, Ke Yao, Janos Nadas, Ann M Bode, Margarita Malakhova, Naomi Oi, Haitao Li, Ronald A Lubet, Zigang Dong
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38261 (2012)
Plant-based polyphenols (i.e., phytochemicals) have been used as treatments for human ailments for centuries. The mechanisms of action of these plant-derived compounds are now a major area of investigation. Thousands of phytochemicals have been isola
Externí odkaz:
https://doaj.org/article/6b8767255c4f4de8a0f3d80118ce82dd
Autor:
Sang Beom Lee, Jing Pan, Donghai Xiong, Katie Palen, Bryon Johnson, Ronald A. Lubet, Robert H. Shoemaker, Jeffrey E. Green, Romaine Ingrid Fernando, Shizuko Sei, Ming You, Yian Wang
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-12 (2023)
Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that has a poor prognosis. TOP2A is a key enzyme in DNA replication and is a therapeutic target for breast and other cancers. TOP2A-specific Th1-promoting epitope
Externí odkaz:
https://doaj.org/article/fec34f822e9940a2a43e7cd6e272efd4
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
There are major hurdles to the use of tyrosine kinase inhibitors (TKIs) and any other agents with significant toxicities (which means practically the preponderance of potential effective agents) in the context of prevention/anti-progression (intercep
Externí odkaz:
https://doaj.org/article/9211c2bb6b414530a034a8876d943ad9
Autor:
Lauren R. Corulli, Denise L. Cecil, Ekram Gad, Marlese Koehnlein, Andrew L. Coveler, Jennifer S. Childs, Ronald A. Lubet, Mary L. Disis
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundOverexpression of nonmutated proteins involved in oncogenesis is a mechanism by which such proteins become immunogenic. We questioned whether overexpressed colorectal cancer associated proteins found at higher incidence and associated with
Externí odkaz:
https://doaj.org/article/3015375de6f44692a214a513d19c7329
Autor:
Ronald A. Lubet, Clinton J. Grubbs, Ann M. Bode, Weidong Wen, Peter T. Vedell, Pengyuan Liu, Zara Ghazoui, Ming You, Yan Lu
XLSX file - 87K, Gene Expression Changes Comparing Control Rat Tumors and Rat Tumors Treated with Vorozole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e727191223c872887148649c29b769a
https://doi.org/10.1158/1940-6207.22524285
https://doi.org/10.1158/1940-6207.22524285
PDF File - 32KB, Table 1. Shape similarity scores of 15 proteins Table 2. Docking score of each of the 4 taxifolin enantiomers against EGFR or PI3-K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9c013a4ce37447d2acedec55d54e6d
https://doi.org/10.1158/1940-6207.22523047.v1
https://doi.org/10.1158/1940-6207.22523047.v1