Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Ronald A Li"'
Publikováno v:
Stem Cell Research, Vol 19, Iss , Pp 76-81 (2017)
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) provide an unlimited source of donor cells for potential cardiac regenerative therapies. However, hPSC-CMs are immature. For instance, hPSC-CMs are only 1/10 of the physical size of their
Externí odkaz:
https://doaj.org/article/e6a8f84b6cd54bcfb09793d2a8d851cd
Autor:
Reza Aghavali, Erin G. Roberts, Yosuke K. Kurokawa, Erica Mak, Martin Y.C. Chan, Andy O.T. Wong, Ronald A. Li, Kevin D. Costa
Publikováno v:
Pharmacological Research, Vol 209, Iss , Pp 107459- (2024)
Cardiac screening of newly discovered drugs remains a longstanding challenge for the pharmaceutical industry. While therapeutic efficacy and cardiotoxicity are evaluated through preclinical biochemical and animal testing, 90 % of lead compounds fail
Externí odkaz:
https://doaj.org/article/7fb2a039a28d455ab39a5bb2f8faee3b
Electrophysiological mechanisms of Brugada syndrome: insights from pre-clinical and clinical studies
Autor:
Gary Tse, Ka Hou Christien Li, Victoria Laxton, Yin Wah Fiona Chan, Wendy Keung, Ronald A Li, Bryan P Yan
Publikováno v:
Frontiers in Physiology, Vol 7 (2016)
Brugada syndrome (BrS), is a primary electrical disorder predisposing affected individuals to sudden cardiac death via the development of ventricular tachycardia and fibrillation (VT/VF). Originally, BrS was linked to mutations in the SCN5A, which en
Externí odkaz:
https://doaj.org/article/c4ac3e70aef547e6939a0b9d53a42b51
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125442 (2015)
Global transcriptional analyses have been performed with human embryonic stem cells (hESC) derived cardiomyocytes (CMs) to identify molecules and pathways important for human CM differentiation, but variations in culture and profiling conditions have
Externí odkaz:
https://doaj.org/article/38b6fff10cd64cc8ba036120038f3b04
Autor:
Ellen Poon, Bin Yan, Shaohong Zhang, Stephanie Rushing, Wendy Keung, Lihuan Ren, Deborah K Lieu, Lin Geng, Chi-Wing Kong, Jiaxian Wang, Hau San Wong, Kenneth R Boheler, Ronald A Li
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77784 (2013)
Human (h) embryonic stem cells (ESC) represent an unlimited source of cardiomyocytes (CMs); however, these differentiated cells are immature. Thus far, gene profiling studies have been performed with non-purified or non-chamber specific CMs. Here we
Externí odkaz:
https://doaj.org/article/e0d31478aa624801bc4aabb47b42bfac
Autor:
Boon-Seng Soh, Shi-Yan Ng, Hao Wu, Kristina Buac, Joo-Hye C. Park, Xiaojun Lian, Jiejia Xu, Kylie S Foo, Ulrika Felldin, Xiaobing He, Massimo Nichane, Henry Yang, Lie Bu, Ronald A Li, Bing Lim, Kenneth R Chien
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Nature Communications 7: Article number: 10774 (2016); Published: 8 March 2016; Updated: 19 July 2016. The affiliation details for Boon-Seng Soh, Lei Bu and Ronald A. Li are incorrect in this Article. The correct addresses of these authors are listed
Externí odkaz:
https://doaj.org/article/4e956a7f772741c5afbc122a18d8f823
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43186 (2012)
Melastatin-like transient receptor potential channel 2 (TRPM2) is an oxidant-sensitive and cationic non-selective channel that is expressed in mammalian vascular endothelium. Here we investigated the functional role of TRPM2 channels in hydrogen pero
Externí odkaz:
https://doaj.org/article/548124af05614afda45829bef7d9c8f6
Autor:
Ming Zhan, Daniel R Riordon, Bin Yan, Yelena S Tarasova, Sarah Bruweleit, Kirill V Tarasov, Ronald A Li, Robert P Wersto, Kenneth R Boheler
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42350 (2012)
Embryonic stem cells (ESCs) are pluripotent and have unlimited self-renewal capacity. Although pluripotency and differentiation have been examined extensively, the mechanisms responsible for self-renewal are poorly understood and are believed to invo
Externí odkaz:
https://doaj.org/article/7b138b80fb85481986fda858f5898af3
Autor:
Ji-Dong Fu, Stephanie N Rushing, Deborah K Lieu, Camie W Chan, Chi-Wing Kong, Lin Geng, Kitchener D Wilson, Nipavan Chiamvimonvat, Kenneth R Boheler, Joseph C Wu, Gordon Keller, Roger J Hajjar, Ronald A Li
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27417 (2011)
MicroRNAs (miRs) negatively regulate transcription and are important determinants of normal heart development and heart failure pathogenesis. Despite the significant knowledge gained in mouse studies, their functional roles in human (h) heart remain
Externí odkaz:
https://doaj.org/article/c906e6f1799b400b8bf5c02dcd4e7ff2
Autor:
Kirill V Tarasov, Yelena S Tarasova, Wai Leong Tam, Daniel R Riordon, Steven T Elliott, Gabriela Kania, Jinliang Li, Satoshi Yamanaka, David G Crider, Gianluca Testa, Ronald A Li, Bing Lim, Colin L Stewart, Yie Liu, Jennifer E Van Eyk, Robert P Wersto, Anna M Wobus, Kenneth R Boheler
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2478 (2008)
The transcription factor B-Myb is present in all proliferating cells, and in mice engineered to remove this gene, embryos die in utero just after implantation due to inner cell mass defects. This lethal phenotype has generally been attributed to a pr
Externí odkaz:
https://doaj.org/article/6aa27e5a8cf6435099a228ed5fdb8023