Výsledky vyhledávání - "Ronald Ouwerkerk"

Akademický článek

Direct pixel to pixel principal strain mapping from tagging MRI using end to end deep convolutional neural network (DeepStrain)

Autor: Khaled Z. Abd-Elmoniem, Inas A. Yassine, Nader S. Metwalli, Ahmed Hamimi, Ronald Ouwerkerk, Jatin R. Matta, Mia Wessel, Michael A. Solomon, Jason M. Elinoff, Ahmed M. Ghanem, Ahmed M. Gharib

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)

Abstract Regional soft tissue mechanical strain offers crucial insights into tissue's mechanical function and vital indicators for different related disorders. Tagging magnetic resonance imaging (tMRI) has been the standard method for assessing the m

Externí odkaz: https://doaj.org/article/289b609cbbd642d3b7f30fe70e97a18b

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Akademický článek

Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis

Publikováno v: Redox Biology, Vol 37, Iss , Pp 101710- (2020)

Oxidative stress (OS) in non-alcoholic fatty liver disease (NAFLD) promotes liver injury and inflammation. Treatment with vitamin E (α-tocopherol, αT), a lipid-soluble antioxidant, improves liver injury but also decreases steatosis, thought to be u

Externí odkaz: https://doaj.org/article/f9220f0a50184ef18cbe5a76bb2c5319

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Volanesorsen, an antisense oligonucleotide to apolipoprotein C-III, increases lipoprotein lipase activity and lowers triglycerides in partial lipodystrophy

Autor: Marissa Lightbourne, Megan Startzell, Kimberley D. Bruce, Brianna Brite, Ranganath Muniyappa, Monica Skarulis, Robert Shamburek, Ahmed M. Gharib, Ronald Ouwerkerk, Mary Walter, Robert H. Eckel, Rebecca J. Brown

Publikováno v: Journal of Clinical Lipidology. 16:850-862

Partial lipodystrophy (PL) syndromes involve deficiency of adipose tissue, causing severe insulin resistance and hypertriglyceridemia. Apolipoprotein C-III (apoC-III) is elevated in PL and is thought to contribute to hypertriglyceridemia by inhibitin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f7fc729587191e7377087d23c5b6f3
https://doi.org/10.1016/j.jacl.2022.06.011

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Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake

Publikováno v: Nature Medicine, 27(2), 344-353
Nature Medicine 27 (2021) 2

The carbohydrate–insulin model of obesity posits that high-carbohydrate diets lead to excess insulin secretion, thereby promoting fat accumulation and increasing energy intake. Thus, low-carbohydrate diets are predicted to reduce ad libitum energy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89eb0e814dbf2782a02670a31d66a938
https://doi.org/10.1038/s41591-020-01209-1

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Skeletal Muscle Magnetic Resonance Biomarkers in GNE Myopathy

Autor: Ronald M. Summers, William A. Gahl, Ronald Ouwerkerk, Chia-Ying Liu, Joseph A. Shrader, Jianhua Yao, Nuria Carrillo, Ami Mankodi, Galen O. Joe, William Kovacs

Publikováno v: Neurology

ObjectiveTo characterize muscle involvement and evaluate disease severity in patients with GNE myopathy using skeletal muscle MRI and proton magnetic resonance spectroscopy (1H-MRS).MethodsSkeletal muscle imaging of the lower extremities was performe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dc1f384c8b571a25286307ae50b19c
https://doi.org/10.1212/wnl.0000000000011231

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Direct pixel to pixel principal strain mapping from tagging MRI using end to end deep convolutional neural network (DeepStrain)

Autor: Ahmed Hamimi, Ahmed M. Ghanem, Ahmed M. Gharib, Khaled Z. Abd-Elmoniem, Ronald Ouwerkerk, Inas A. Yassine, Jatin R. Matta, Mia Wessel, Nader S. Metwalli, Jason M. Elinoff, Michael A. Solomon

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Scientific Reports

Regional soft tissue mechanical strain offers crucial insights into tissue's mechanical function and vital indicators for different related disorders. Tagging magnetic resonance imaging (tMRI) has been the standard method for assessing the mechanical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09be157008a91d37c8decc034b1e5807
https://doi.org/10.1038/s41598-021-02279-y

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Native-resolution myocardial principal Eulerian strain mapping using convolutional neural networks and Tagged Magnetic Resonance Imaging

Autor: Ronald Ouwerkerk, Nader S. Metwalli, Jatin R. Matta, Khaled Z. Abd-Elmoniem, Ahmed Hamimi, Inas A. Yassine, Ahmed M. Ghanem, Jason M. Elinoff, Michael A. Solomon, Ahmed M. Gharib

Publikováno v: Comput Biol Med

Background Assessment of regional myocardial function at native pixel-level resolution can play a crucial role in recognizing the early signs of the decline in regional myocardial function. Extensive data processing in existing techniques limits the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df7dc5e486cb44722eb4f21bc41e4de
https://pubmed.ncbi.nlm.nih.gov/34836627

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Proton MR Spectroscopy Measurements of White and Brown Adipose Tissue in Healthy Humans: Relaxation Parameters and Unsaturated Fatty Acids

Autor: Kong Y. Chen, Ahmed Hamimi, Zahraa Abdul Sater, Jatin R. Matta, Janet F. Eary, Ahmed M. Gharib, Ronald Ouwerkerk, Khaled Z. Abd-Elmoniem, Aaron M. Cypess

Publikováno v: Radiology. 299(2)

Background Activation of brown adipose tissue (BAT) in rodents increases lipolysis in white adipose tissue (WAT) and improves glucose tolerance. Adult humans can have metabolically active BAT. Implications for diabetes and obesity in humans require a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e2d9da217a2ae775728b6a93bc010b
https://pubmed.ncbi.nlm.nih.gov/33729011

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