Výsledky vyhledávání - "Ronak Haj Ersan"

2-Phenyl substituted Benzimidazole derivatives: Design, synthesis, and evaluation of their antiproliferative and antimicrobial activities

Autor: Ronak Haj Ersan, Burak Kuzu, Derya Yetkin, Mehmet Abdullah Alagoz, Aylin Dogen, Serdar Burmaoglu, Oztekin Algul

Publikováno v: Medicinal Chemistry Research. 31:1192-1208

The inability to meet the desired outcomes of anticancer treatment and decrease in treatment success of bacterial and fungal infections accelerated research in these areas. Our research group has conducted numerous studies, especially on benzimidazol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb70c7aee19a0fd098cc8a4948bec7f8
https://doi.org/10.1007/s00044-022-02900-3

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Effect of Benzimidazole Compound on Endoplasmic Reticulum Stress and Unfolded Protein Response Signaling Pathways in Hydrogen Peroxide-Induced BEAS-2B Cells

Autor: Aysel Eraslan Sakar, Meral Urhan Kucuk, Ronak Haj Ersan, Oztekin Algul

The main aim of the study was to reveal the effects of endoplasmic reticulum (ER) stress on human bronchial epithelial cells BEAS-2B at gene and protein levels under oxidative stress conditions. The second aim of the study was to investigate whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f954318b5f1c7f27537952894a81c947
https://doi.org/10.21203/rs.3.rs-2332298/v1

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In vitro antiproliferative activity of some fluoro-substituted benzimidazole-based scaffolds

Autor: Ronak Haj Ersan, Nizami Duran

Publikováno v: Bioorganic and Medicinal Chemistry Reports. 4:10-17

In the present work, a series of fluoro-substituted benzimidazole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of these compounds was investigated using MTT assay. Fluoro-substituted benzimidaz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea8e365dbd06dc694a3032689bf65d13
https://doi.org/10.25135/acg.bmcr.25.21.05.2065

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Bisbenzimidazole Derivatives as Potential Antimicrobial Agents: Design, Synthesis, Biological Evaluation and Pharmacophore Analysis

Autor: Kayhan Bolelli, Serdar Burmaoglu, Serpil Gonca, Aylin Döğen, Ronak Haj Ersan, Oztekin Algul

Publikováno v: Pharmaceutical Chemistry Journal. 55:149-158

In an attempt to design and synthesize a potent class of antimicrobials, 1,2-phenylenediamine derivatives were reacted with various aliphatic and heteroaliphatic dicarboxylic acids to generate a small library of 26 head-to-head bisbenzimidazole compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3ec1e46db4f0284925b52247887b1d2
https://doi.org/10.1007/s11094-021-02389-x

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New-Generation Benzimidazole-Based Plasmid Delivery Reagents with High Transfection Efficiencies on the Mammalian Cells

Autor: Ronak Haj Ersan, Burak Kuzu, Furkan Ayaz, Oztekin Algul

Publikováno v: In Vitro Cellular & Developmental Biology - Animal. 56:34-41

Gene transfer and gene therapy studies require high-efficiency gene delivery reagents. By transferring the piece of DNA that we are interested in, we can alter the expression of certain gene or genes to further characterize its role in the cell funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c91d53edc320df53602c564b8e4e5b0
https://doi.org/10.1007/s11626-019-00418-4

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Bisbenzoxazole derivatives had an antiinflammatory effect on in vitro stimulatedmacrophages

Autor: Oztekin Algul, Furkan Ayaz, Ronak Haj Ersan, Qadar Ahmed Isse, Rusmeenee Kheeree

Publikováno v: TURKISH JOURNAL OF CHEMISTRY. 43:963-971

Benzoxazoles are DNA base bioisosteres and studies suggest that their derivatives have antiproliferative activities. Based on their antiproliferative activities they have been mostly studied as new generation anticancer drugs. In our study we exploit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cbb938f2cd7d8f1008d7ad024d993cc
https://doi.org/10.3906/kim-1812-54

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Head-to-head bisbenzazole derivatives as antiproliferative agents: design, synthesis, in vitro activity, and SAR analysis

Autor: Nizami Duran, Mehmet Abdullah Alagöz, Oztekin Algul, Ronak Haj Ersan, Serdar Burmaoglu, Tugba Ertan-Bolelli

Publikováno v: Molecular diversity. 25(4)

In the present work, a series of bisbenzazole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of these compounds was investigated using MTT assay. Bisbenzazole derivatives showed significant antip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47c70d6f4a14ef9704871b7c3eb1caa
https://pubmed.ncbi.nlm.nih.gov/32556804

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An efficient synthesis of novel di-heterocyclic benzazole derivatives and evaluation of their antiproliferative activities

Autor: Nizami Duran, Ronak Haj Ersan, Mehmet Abdullah Alagöz, Serdar Burmaoglu, Oztekin Algul

A series of unsymmetrical nine di-heterocyclic compounds of benzazole derivatives were synthesized at one step via cyclization reaction. The compounds evaluated for in vitro cytotoxic activity against A549, A498, HeLa, and HepG2 cancer cell lines. Th

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