Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ronak Ghanbari-Azarnier"'
Autor:
Zhe Jiang, YoungJun Ju, Amjad Ali, Philip E. D. Chung, Patryk Skowron, Dong-Yu Wang, Mariusz Shrestha, Huiqin Li, Jeff C. Liu, Ioulia Vorobieva, Ronak Ghanbari-Azarnier, Ethel Mwewa, Marianne Koritzinsky, Yaacov Ben-David, James R. Woodgett, Charles M. Perou, Adam Dupuy, Gary D. Bader, Sean E. Egan, Michael D. Taylor, Eldad Zacksenhaus
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Metastatic breast-cancer is a major cause of death in women worldwide, yet the relationship between oncogenic drivers that promote metastatic versus primary cancer is still contentious. To elucidate this relationship in treatment-naive anima
Externí odkaz:
https://doaj.org/article/141fc3ada18346a59e6af3fd9ea5bbbb
Autor:
Philip E. D. Chung, Deena M. A. Gendoo, Ronak Ghanbari-Azarnier, Jeff C. Liu, Zhe Jiang, Jennifer Tsui, Dong-Yu Wang, Xiao Xiao, Bryan Li, Adrian Dubuc, David Shih, Marc Remke, Ben Ho, Livia Garzia, Yaacov Ben-David, Seok-Gu Kang, Sidney Croul, Benjamin Haibe-Kains, Annie Huang, Michael D. Taylor, Eldad Zacksenhaus
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Pineoblastoma is a rare pediatric cancer. Here, the authors present inactivation of Rb plus p53 via a WAP-Cre transgene induces metastatic pineoblastoma resembling human disease, and using this model, predict tricyclic antidepressants as a potential
Externí odkaz:
https://doaj.org/article/8d8533d286084918a97e2d6644e11fc1
Autor:
Eldad Zacksenhaus, Jeff C. Liu, Letizia Granieri, Ioulia Vorobieva, Dong-Yu Wang, Ronak Ghanbari-Azarnier, Huiqin Li, Amjad Ali, Philip E.D. Chung, YoungJun Ju, Zhe Jiang, Mariusz Shrestha
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 4 (2018)
The dual phosphatase CDC25 has recently been identified as a target for diverse triple-negative breast cancers including RB1/PTEN/P53-deficient tumors. Moreover, CDC25 inhibitors effectively synergize with PI3K inhibitors to suppress tumor growth. We
Externí odkaz:
https://doaj.org/article/b800192a59594419840d71c3a1e6fd55
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 7, Pp 712-719 (2013)
Desmoid tumor (also called aggressive fibromatosis) is a lesion of mesenchymal origin that can occur as a sporadic tumor or a manifestation of the preneoplastic syndrome, familial adenomatous polyposis caused by a mutation in adenomatous polyposis co
Externí odkaz:
https://doaj.org/article/c5736d05b134477d840d090aa53cbb6e
Autor:
Benjamin A. Alman, Jay S. Wunder, Weishi Wang, Phil Zhang, Feifei Zheng, Jiayi Hu, Raymond Poon, Heather Whetstone, Ronak Ghanbari- Azarnier, Shingo Sato, Ilkyu Han, Qingxia Wei, Chang Ye Yale Wang
PDF file - 3.4MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250e07a100deb9fd33b16beb15766624
https://doi.org/10.1158/0008-5472.22393466.v1
https://doi.org/10.1158/0008-5472.22393466.v1
Autor:
Ronak Ghanbari-Azarnier, Yaacov Ben-David, Michael D. Taylor, Deena M.A. Gendoo, Ben Ho, Marc Remke, Seok Gu Kang, Benjamin Haibe-Kains, Zhe Jiang, David Shih, Sidney E Croul, Bryan K. Li, Eldad Zacksenhaus, Jeff C. Liu, Xiao Xiao, Jennifer Tsui, Philip E.D. Chung, Adrian M. Dubuc, Dong Yu Wang, Livia Garzia, Annie Huang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Nature Communications
Nature Communications
Pineoblastoma is a rare pediatric cancer induced by germline mutations in the tumor suppressors RB1 or DICER1. Presence of leptomeningeal metastases is indicative of poor prognosis. Here we report that inactivation of Rb plus p53 via a WAP-Cre transg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e61b850bcc2b2c4252c324161b1ff4
https://doaj.org/article/8d8533d286084918a97e2d6644e11fc1
https://doaj.org/article/8d8533d286084918a97e2d6644e11fc1
Autor:
Shingo Sato, Phil Zhang, Feifei Zheng, Jay S. Wunder, Heather Whetstone, Chang Ye Yale Wang, Ronak Ghanbari Azarnier, Raymond Poon, Benjamin A. Alman, Qingxia Wei, Weishi Wang, Ilkyu Han, Jiayi Hu
Publikováno v:
Cancer Research. 72:1013-1022
Like many solid tumors, sarcomas are heterogeneous and include a small fraction of the so-called side population (SP) cells with stem-like tumor-initiating potential. Here, we report that SP cells from a soft tissue tumor of enigmatic origin termed u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220211018b74cdb14d1cd33ec2b6fdcc
https://doi.org/10.1158/0008-5472.can-11-2531
https://doi.org/10.1158/0008-5472.can-11-2531
Autor:
YoungJun Ju, Huiqin Li, Amjad Ali, Eldad Zacksenhaus, Dong-Yu Wang, Mariusz Shrestha, Philip E.D. Chung, Jeff C. Liu, Letizia Granieri, Zhe Jiang, Ronak Ghanbari-Azarnier, Ioulia Vorobieva
Publikováno v:
Molecular & Cellular Oncology. 5:e1481814
The dual phosphatase CDC25 has recently been identified as a target for diverse triple-negative breast cancers including RB1/PTEN/P53-deficient tumors. Moreover, CDC25 inhibitors effectively synergize with PI3K inhibitors to suppress tumor growth. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80bc876b3da1885b329c32299f128b1e
https://doi.org/10.1080/23723556.2018.1481814
https://doi.org/10.1080/23723556.2018.1481814
Autor:
Ronak Ghanbari Azarnier, Philip E.D. Chung, Zhe Jiang, Eldad Zacksenhaus, Agatha Zuchelkowski
Publikováno v:
Cancer Research. 77:2801-2801
Triple-negative breast cancer (TNBCs) is an aggressive subtype with poor prognosis; drug-resistant metastases are common and highly lethal for which identification of therapeutic targets is of major medical interest. Previously we demonstrated that d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6f2aeece088e74378ca08c6e11bd31a
https://doi.org/10.1158/1538-7445.am2017-2801
https://doi.org/10.1158/1538-7445.am2017-2801