Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Rona R, Ramsay"'
Autor:
Rona R. Ramsay, Alen Albreht
Publikováno v:
Chemistry, Vol 3, Iss 3, Pp 959-978 (2021)
We have structure, a wealth of kinetic data, thousands of chemical ligands and clinical information for the effects of a range of drugs on monoamine oxidase activity in vivo. We have comparative information from various species and mutations on kinet
Externí odkaz:
https://doaj.org/article/2bcfd2f5ab9f4755b13d361f1c1ee724
Autor:
Adel Amer, Abdelrahman H. Hegazi, Mohammed Khalil Alshekh, Hany E. A. Ahmed, Saied M. Soliman, Antonin Maniquet, Rona R. Ramsay
Publikováno v:
Royal Society Open Science, Vol 7, Iss 4 (2020)
A new series of N'-substituted benzylidene-2-(4-oxo-2-phenyl-1,4-dihydroquinazolin-3(2H)-yl)acetohydrazide (5a–5h) has been synthesized, characterized by FT-IR, NMR spectroscopy and mass spectrometry and tested against human monoamine oxidase (MAO)
Externí odkaz:
https://doaj.org/article/770c4c2108634a389057c5c03c1db3e7
Autor:
Rona R. Ramsay, Marija R. Popovic-Nikolic, Katarina Nikolic, Elisa Uliassi, Maria Laura Bolognesi
Publikováno v:
Clinical and Translational Medicine, Vol 7, Iss 1, Pp 1-14 (2018)
Abstract Diseases of infection, of neurodegeneration (such as Alzheimer’s and Parkinson’s diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identify potential modulators for m
Externí odkaz:
https://doaj.org/article/f64c404e4da0439c8233adec1796bb0a
Autor:
Rona R. Ramsay, Livia Basile, Antonin Maniquet, Stefanie Hagenow, Matteo Pappalardo, Maria Chiara Saija, Sharon D. Bryant, Alen Albreht, Salvatore Guccione
Publikováno v:
Molecules, Vol 25, Iss 24, p 5908 (2020)
The irreversible inhibitors of monoamine oxidases (MAO) slow neurotransmitter metabolism in depression and neurodegenerative diseases. After oxidation by MAO, hydrazines, cyclopropylamines and propargylamines form a covalent adduct with the flavin co
Externí odkaz:
https://doaj.org/article/67bfa272bc784eb886c8a06c9f0a04b5
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Successful propargylamine drugs such as deprenyl inactivate monoamine oxidase (MAO), a target in multi-faceted approaches to prevent neurodegeneration in the aging population, but the chemical structure and mechanism of the irreversible inhibition ar
Externí odkaz:
https://doaj.org/article/e83048c9959646f28a08618a7e7135f7
Autor:
Rona R. Ramsay
Publikováno v:
Methods in Molecular Biology ISBN: 9781071626429
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9b21e0816a6b1ad629a0f779e1483c1
https://doi.org/10.1007/978-1-0716-2643-6_6
https://doi.org/10.1007/978-1-0716-2643-6_6
Autor:
Rona R, Ramsay
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2558
The covalently bound FAD cofactor in monoamine oxidase (MAO) is reduced by the amine substrate and reoxidized by oxygen. Visible spectroscopy provides a convenient tool to study the interaction of ligands and the kinetics of the half-reactions for me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fec31d4caa888a37f5faaa53778d07f3
https://pubmed.ncbi.nlm.nih.gov/36169856
https://pubmed.ncbi.nlm.nih.gov/36169856
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
Growing evidence supports the view that neurodegenerative diseases have multiple and common mechanisms in their aetiologies. These multifactorial aspects have changed the broadly common assumption that selective drugs are superior to ‘dirty drugs
Externí odkaz:
https://doaj.org/article/7f5cee5a247e426d9aed1c3793677f81
Autor:
Mercedes eUnzeta, Gerard eEsteban, Irene eBolea, Wieslawa Agnieszka Fogel, RONA R. RAMSAY, Moussa B.H. Youdim, Keith F Tipton, Jose eMarco-Contelles
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
Alzheimer's disease (AD), the most common form of adult onset dementia, is an age-related neurodegenerative disorder characterized by progressive memory loss, decline in language skills and other cognitive impairments. Although its etiology is not co
Externí odkaz:
https://doaj.org/article/7bc18a6afc5f497390ee7cd4fdbc5ff1
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
Alzheimer’s disease is a complex and multifactorial disease for which the mechanism is still not fully understood. As new insights into disease progression are discovered, new drugs must be designed to target those aspects of the disease that cause
Externí odkaz:
https://doaj.org/article/c463b10073fb43019ef869f1488c1326