Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Rona Ortenberg"'
Autor:
Erez Nissim Baruch, Rona Ortenberg, Camila Avivi, Liat Anafi, Daniela Dick-Necula, Chani Stossel, Yonatan Moshkovits, Orit Itzhaki, Michal Judith Besser, Jacob Schachter, Iris Barshack, Gal Markel
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Omics analyses often result in dozens to hundreds of potential targets, requiring validation for their biological relevance. Current high-throughput functional investigation methods are frequently labor-intensive, expensive, and display low reproduci
Externí odkaz:
https://doaj.org/article/97011e2deb4142d48b96ebe2f8f2005d
Autor:
Yael Nemlich, Erez Nissim Baruch, Michal Judith Besser, Einav Shoshan, Menashe Bar-Eli, Liat Anafi, Iris Barshack, Jacob Schachter, Rona Ortenberg, Gal Markel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
In metastatic melanoma, ADAR1 is downregulated, facilitating proliferation. Here, the authors show an ADAR1-dependent and RNA-editing-independent regulation of melanoma invasion mediated by ITGB3 expression, which can be reversed when ITGB3 is blocke
Externí odkaz:
https://doaj.org/article/b3931c919fb84915ae92ef05fa08880c
Autor:
Karin Kfir-Elirachman, Rona Ortenberg, Bella Vizel, Michal J Besser, Iris Barshack, Jacob Schachter, Yael Nemlich, Gal Markel
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 4, Pp 401-409 (2018)
BRAF becomes constitutively activated in 50% to 70% of melanoma cases. CEACAM1 has a dual role in melanoma, including facilitation of cell proliferation and suppression of infiltrating lymphocytes, which are consistent with its value as a marker for
Externí odkaz:
https://doaj.org/article/36adb8e2b29244279eb2a07e97353443
Autor:
Alon Vitenshtein, Yiska Weisblum, Sebastian Hauka, Anne Halenius, Esther Oiknine-Djian, Pinchas Tsukerman, Yoav Bauman, Yotam Bar-On, Noam Stern-Ginossar, Jonatan Enk, Rona Ortenberg, Julie Tai, Gal Markel, Richard S. Blumberg, Hartmut Hengel, Stipan Jonjic, Dana G. Wolf, Heiko Adler, Robert Kammerer, Ofer Mandelboim
Publikováno v:
Cell Reports, Vol 15, Iss 11, Pp 2331-2339 (2016)
Cells in our body can induce hundreds of antiviral genes following virus sensing, many of which remain largely uncharacterized. CEACAM1 has been previously shown to be induced by various innate systems; however, the reason for such tight integration
Externí odkaz:
https://doaj.org/article/d604de9f90e5446387a4f99113b42555
Autor:
Rona Ortenberg, Gilli Galore-Haskel, Ilanit Greenberg, Bella Zamlin, Sivan Sapoznik, Eyal Greenberg, Iris Barshack, Camila Avivi, Yulia Feiler, Israel Zan-Bar, Michal J. Besser, Ester Azizi, Friedman Eitan, Jacob Schachter, Gal Markel
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 5, Pp 451-460 (2014)
The prognostic value of the carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) in melanoma was demonstrated more than a decade ago as superior to Breslow score. We have previously shown that intercellular homophilic CEACAM1 interactions prot
Externí odkaz:
https://doaj.org/article/93794b5e9efc4062a0736edc0d2e5860
Autor:
Michal J Besser, Tsipi Shoham, Orit Harari-Steinberg, Naama Zabari, Rona Ortenberg, Arkadi Yakirevitch, Arnon Nagler, Ron Loewenthal, Jacob Schachter, Gal Markel
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57922 (2013)
Natural killer (NK) cells have long been considered as potential agents for adoptive cell therapy for solid cancer patients. Until today most studies utilized autologous NK cells and yielded disappointing results. Here we analyze various modular stra
Externí odkaz:
https://doaj.org/article/954811d642ce4e3ea574b150153a18ed
Autor:
Orit Itzhaki, Eyal Greenberg, Bruria Shalmon, Adva Kubi, Avraham J Treves, Ronnie Shapira-Frommer, Camilla Avivi, Rona Ortenberg, Eytan Ben-Ami, Jacob Schachter, Michal J Besser, Gal Markel
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57160 (2013)
Vasculogenic mimicry (VM) describes functional vascular channels composed only of tumor cells and its presence predicts poor prognosis in melanoma patients. Inhibition of this alternative vascularization pathway might be of clinical importance, espec
Externí odkaz:
https://doaj.org/article/0534320b2f49433a87561bc72c1473b3
Autor:
Sivan Sapoznik, Ohad Hammer, Rona Ortenberg, Michal J. Besser, Tehila Ben-Moshe, Jacob Schachter, Gal Markel
Publikováno v:
Clinical and Developmental Immunology, Vol 2012 (2012)
The immune system fights cancer and sometimes temporarily eliminates it or reaches an equilibrium stage of tumor growth. However, continuous immunological pressure also selects poorly immunogenic tumor variants that eventually escape the immune contr
Externí odkaz:
https://doaj.org/article/160ba8c7a4c7479db5ff46d04f201b6e
Autor:
Eyal Greenberg, Liat Hershkovitz, Orit Itzhaki, Steven Hajdu, Yael Nemlich, Rona Ortenberg, Nir Gefen, Liat Edry, Shira Modai, Yona Keisari, Michal J Besser, Jacob Schachter, Noam Shomron, Gal Markel
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18936 (2011)
MicroRNAs (miRNAs) are small non-coding RNAs with regulatory roles, which are involved in a broad spectrum of physiological and pathological processes, including cancer. A common strategy for identification of miRNAs involved in cell transformation i
Externí odkaz:
https://doaj.org/article/c83c8eb018fb4a90a218b7a8494a17e4
Autor:
Gal Markel, Rachel Seidman, Michal J Besser, Naama Zabari, Rona Ortenberg, Ronnie Shapira, Avraham J Treves, Ron Loewenthal, Arie Orenstein, Arnon Nagler, Jacob Schachter
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5597 (2009)
NK cells are key players in anti tumor immune response, which can be employed in cell-based therapeutic modalities. One of the suggested ways to amplify their anti tumor effect, especially in the field of stem cell transplantation, is by selecting do
Externí odkaz:
https://doaj.org/article/caabac5ef00546278b83e6cc825ebfd2