Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

Autor: Eduardo Nagore, Caroline Hayward, Christopher I. Amos, Douglas F. Easton, Zaida García-Casado, Julie Lang, Anjali K. Henders, Veronica Höiom, Lisa Bowdler, Kathryn P. Burdon, Laura Del Regno, Nick Orr, Per Arne Andresen, Tongwu Zhang, Rose Yang, Myriam Brossard, Eric K. Moses, Dirk Schadendorf, Laura Cattaneo, Casey Rowe, Essen-Heidelberg Investigators, Hans-Joachim Schulze, Jamie E Craig, D. Timothy Bishop, Anne E. Cust, Johan Hansson, David E. Elder, Nelleke A. Gruis, Donato Calista, Wei V. Chen, Abrar A. Qureshi, Amy Hutchinson, Pilar Galan, Leanne Wallace, Jennifer H. Barrett, Nilesh J. Samani, Maria Teresa Landi, Per Helsing, Andreas Hadjisavvas, Fengju Song, Celia Requena, Elizabeth M. Gillanders, Arantxa Rodriguez, Joan Anton Puig-Butille, Blair H. Smith, Mark Smithers, Michael Malasky, Marianna Sanna, Miriam Potrony, Maria A. Loizidou, Evangelos Evangelou, Richard A. Scolyer, Karen A. Pooley, Rachel E. Neale, Mario Falchi, Adèle C. Green, Monica Rodolfo, Ketty Peris, Licia Rivoltini, Mark M. Iles, Catherine M. Olsen, Alexander J. Stratigos, Tadeusz Dębniak, Weiyin Zhou, H. Peter Soyer, Xin Li, Margaret A. Tucker, Rajesh Kumar, Håkan Olsson, Anders Molven, Nicholas G. Martin, Anthony J. Swerdlow, Aurelie Vogt, Lars A. Akslen, Stuart MacGregor, Sarah V. Ward, Hamida Mohamdi, Bruna Dalmasso, Grant W. Montgomery, Rona M. MacKie, Esther Azizi, Gonçalo R. Abecasis, Chiara Menin, Alison M. Dunning, Ibd investigators, Kevin M. Brown, Jiali Han, Veryan Codd, Graham J. Mann, Nicholas K. Hayward, Marko Hočevar, Eitan Friedman, Richard A. Sturm, Paola Queirolo, Qtwin Investigators, Lawrie Wheeler, Lars G. Fritsche, Shenying Fang, Kiarash Khosrotehrani, Nicole A Kukutsch, Pol Gimenez-Xavier, Belynda Hicks, Matthew Zawistowski, Alessia Visconti, Jessica Harris, Chad M. Brummett, Paola Ghiorzo, andMe, David G. Hunter, Veronique Bataille, Julia Newton-Bishop, Srdjan Novaković, Amfs Investigators, Siranoush Manoukian, Jianxin Shi, Mitchell J. Machiela, G. Mark Lathrop, Josep Malvehy, Katerina P. Kypreou, Susana Puig, Dale R. Nyholt, I. Stefanaki, Maria Concetta Fargnoli, Lisa A. Simms, Kerrie McAloney, M. Malt, Adam J. Trower, Matthew Law, Lei Song, Paul D.P. Pharoah, Christian Ingvar, Jiyeon Choi, Alisa M. Goldstein, Jeffrey E. Lee, Mark Harland, Cristina Pellegrini, Daniela Massi, Sarah Simi, Scott D. Gordon, Jacobo Martinez, Florence Demenais, Kristine Jones, Graham L. Radford-Smith, David C. Whiteman, Lorenza Pastorino, Lisa Elefanti, Arcangela De Nicolo, Mario Mandalà, Juliette Randerson-Moor, Q-Mega, Jan Lubinski, Stephen J. Chanock, Marie-Françoise Avril, David L. Duffy, Helen Gogas, Nienke van der Stoep, Peter A. Kanetsky, Georgina V. Long

Publikováno v: Nature Genetics
Nature Genetics, Nature Publishing Group, 2020, 52 (5), pp.494-504. ⟨10.1038/s41588-020-0611-8⟩
Nature genetics
Nature Genetics, 52(5), 494-504. NATURE PUBLISHING GROUP

Meta-analysis of 36,760 cases and 375,188 controls identifies 54 loci associated with susceptibility to cutaneous melanoma. Further analysis combining nevus count and hair color GWAS results provide insights into the genetic architecture of melanoma.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0663ba533ad6d0d069e8827e0d374241
https://discovery.dundee.ac.uk/files/49101915/Landi_2019_main_text_NG_A52232R2_15012020_2_.pdf

Biologic markers of sun exposure and melanoma risk in women: Pooled case-control analysis

Autor: Elizabeth A. Holly, Adèle C. Green, Thomas M. Mack, Roberto Zanetti, Stefano Rosso, Julia A. Newton Bishop, Catherine M. Olsen, Michael S. Zens, Therese A. Stukel, Richard P. Gallagher, C. D'Arcy J. Holman, David C. Whiteman, Margaret R. Karagas, J. Mark Elwood, Marianne Berwick, Anne Østerlind, Rona M. MacKie, Connie Kirkpatrick, Veronique Bataille, Anthony J. Swerdlow, Yu-Mei Chang, Bruce K. Armstrong, Carlotta Sacerdote

Publikováno v: International Journal of Cancer. 129:713-723

A model has been proposed whereby melanomas arise through two distinct pathways dependent on the relative influence of host susceptibility and sun exposure. Such pathways may explain site-specific patterns of melanoma occurrence. To explore this mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad691dc9e898fc914ac9589f367d7e5c
https://doi.org/10.1002/ijc.25691

Genome-wide association study identifies three loci associated with melanoma risk

Autor: Srdjan Novaković, G. Mark Lathrop, Veronica Höiom, Diana Zelenika, Pilar Galan, Julia A. Newton Bishop, Johan Hansson, D. Timothy Bishop, Anne Boland, Nicholas G. Martin, Eve Corda, Maria Teresa Landi, Donato Calista, Elizabeth M. Gillanders, Lisa A. Cannon-Albright, Marie-Françoise Avril, Richard F. Kefford, Tadeusz Dębniak, Thomas Chin-A-Woeng, Graham J. Mann, Bert Bakker, Jennifer H. Barrett, Gilli Galore-Haskel, Peter A. Kanetsky, Paola Ghiorzo, Christian Ingvar, Joanne F. Aitken, Marjan M. Weiss, Giovanna Bianchi-Scarrà, Josep Malvehy, Juliette Randerson-Moor, David E. Elder, Kevin M. Brown, Jan Lubinski, Nicholas K. Hayward, Florence Demenais, Mark Harland, John L. Hopper, Susana Puig, Marko Hočevar, John C. Taylor, Frans A. van Nieuwpoort, Nelleke A. Gruis, Julie Lang, Grant W. Montgomery, Håkan Olsson, Rona M. MacKie, Ivo Gut, Alisa M. Goldstein, Brigitte Bressac-de Paillerets, Mark M. Iles, Wilbert van Workum, Esther Azizi

Publikováno v: Nature Genetics. 41:920-925

We report a genome-wide association study of melanoma conducted by the GenoMEL consortium based on 317K tagging SNPs for 1,650 selected cases and 4,336 controls, with replication in an additional two cohorts (1,149 selected cases and 964 controls fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da10f6941631744914f79c81f4b0ca7
https://doi.org/10.1038/ng.411

Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls

Autor: Håkan Olsson, Nelleke A. Gruis, Elizabeth A. Holly, Anthony A. Swerdlow, Rona M. MacKie, Michael S. Zens, Tim K. Lee, Wilma Bergman, Loic Le Marchand, Veronique Bataille, Adèle C. Green, Christian Ingvar, Mark Elwood, Anne Østerlind, Paige M. Bracci, Richard P. Gallagher, Marianne Berwick, Victor Siskind, Timothy R. Rebbeck, Timothy Bishop, Julia Newton-Bishop, Linda Titus-Ernstoff, Yu-Mei Chang, Peter A. Kanetsky, Bruce K. Armstrong, Peter Sasieni, Margaret R. Karagas, Marc S. Ernstoff, Jennifer H. Barrett

Publikováno v: International Journal of Epidemiology

Background Melanoma risk is related to sun exposure; we have investigated risk variation by tumour site and latitude. Methods We performed a pooled analysis of 15 case-control studies (5700 melanoma cases and 7216 controls), correlating patterns of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390812d86738505158eeb1038d9f66fe
https://doi.org/10.1093/ije/dyp166

Long-Term Protective Effect of Mature DC-LAMP+ Dendritic Cell Accumulation in Sentinel Lymph Nodes Containing Micrometastatic Melanoma

Autor: Alain Spatz, Serge Lebecque, John F. Thompson, Ulrich Keilholz, Martin G. Cook, Bruce Elliott, Stefan Suciu, Raghwa Sharma, Caroline Robert, Elena Musat, Alessandro Testori, Rona M. MacKie, Oliver Gugerli, Alexander M.M. Eggermont, Richard A. Scolyer, Donata Rimoldi, Danielle Liénard, Eric Angevin

Publikováno v: Clinical Cancer Research, 13(13), 3825-3830. American Association for Cancer Research Inc.

Purpose: In a previous immunohistochemical study of dendritic cells (DC) in sentinel lymph nodes (SLN) draining regressing melanomas, we found that the accumulation of mature DC-LAMP+ DCs in SLNs was associated with local expansion of antigen-specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55edffdf8860184552c9edb7ee793e93
https://doi.org/10.1158/1078-0432.ccr-07-0358