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pro vyhledávání: '"Rona M. Barron"'
Publikováno v:
Brain Communications. 3
Primary hippocampal cell cultures are routinely used as an experimentally accessible model platform for the hippocampus and brain tissue in general. Containing multiple cell types including neurons, astrocytes and microglia in a state that can be rea
Autor:
Nadia L Tuzi, Enrico Cancellotti, Herbert Baybutt, Lorraine Blackford, Barry Bradford, Chris Plinston, Anne Coghill, Patricia Hart, Pedro Piccardo, Rona M Barron, Jean C Manson
Publikováno v:
PLoS Biology, Vol 6, Iss 4, p e100 (2008)
The expression of the prion protein (PrP) is essential for transmissible spongiform encephalopathy (TSE) or prion diseases to occur, but the underlying mechanism of infection remains unresolved. To address the hypothesis that glycosylation of host Pr
Externí odkaz:
https://doaj.org/article/cded1fa5196a4c4c9b1ac21ceeb8db25
Publikováno v:
Journal of the Neurological Sciences
The conversion of cellular prion protein (PrP) into a misfolded isoform is central to the development of prion diseases. However, the heterogeneous phenotypes observed in prion disease may be linked with the presence of other misfolded proteins in th