Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Rona K. Graham"'
Autor:
Bibiana K.Y. Wong, Dagmar E. Ehrnhoefer, Rona K. Graham, Dale D.O. Martin, Safia Ladha, Valeria Uribe, Lisa M. Stanek, Sonia Franciosi, Xiaofan Qiu, Yu Deng, Vlad Kovalik, Weining Zhang, Mahmoud A. Pouladi, Lamya S. Shihabuddin, Michael R. Hayden
Publikováno v:
Neurobiology of Disease, Vol 76, Iss , Pp 24-36 (2015)
Huntington Disease (HD) is a progressive neurodegenerative disease caused by an elongated CAG repeat in the huntingtin (HTT) gene that encodes a polyglutamine tract in the HTT protein. Proteolysis of the mutant HTT protein (mHTT) has been detected in
Externí odkaz:
https://doaj.org/article/93e64c557c8447099a3caa50455f7c0b
Autor:
Mahmoud A. Pouladi, Elsa Brillaud, Yuanyun Xie, Paola Conforti, Rona K. Graham, Dagmar E. Ehrnhoefer, Sonia Franciosi, Weining Zhang, Patrick Poucheret, Elsa Compte, Jean-Claude Maurel, Chiara Zuccato, Elena Cattaneo, Christian Néri, Michael R. Hayden
Publikováno v:
Neurobiology of Disease, Vol 48, Iss 3, Pp 282-289 (2012)
Huntington disease (HD), a neurodegenerative disorder caused by an expanded CAG repeat in the HTT gene, remains without a treatment to modify the course of the illness. Lithium, a drug widely used for the treatment of bipolar disorder, has been shown
Externí odkaz:
https://doaj.org/article/a662945d3163413c9b1c8e5189ed755b
Publikováno v:
Neurobiology of Disease, Vol 31, Iss 1, Pp 80-88 (2008)
Huntington's disease (HD) is caused by a progressive loss of striatal medium spiny neurons (MSN). The molecular trigger of HD is a polyglutamine expansion in the Huntingtin protein (Htt). The mutant Htt protein forms insoluble nuclear aggregates whic
Externí odkaz:
https://doaj.org/article/1c4ebfe009384610882acc08e6658146
Autor:
Jeremy M. Van Raamsdonk, Martina Metzler, Elizabeth Slow, Jacqueline Pearson, Claudia Schwab, Jeffrey Carroll, Rona K. Graham, Blair R. Leavitt, Michael R. Hayden
Publikováno v:
Neurobiology of Disease, Vol 26, Iss 1, Pp 189-200 (2007)
The YAC128 mouse model of Huntington disease (HD) exhibits motor abnormalities, cognitive dysfunction and selective neuropathology which are similar to the human disease. Backcrossing YAC128 mice from the FVB/N strain onto the C57BL/6 strain and the
Externí odkaz:
https://doaj.org/article/0d1d1167deae406faa2423f883a48107
Autor:
Paolo Guidetti, Gillian P. Bates, Rona K. Graham, Michael R. Hayden, Blair R. Leavitt, Marcy E. MacDonald, Elizabeth J. Slow, Vanessa C. Wheeler, Ben Woodman, Robert Schwarcz
Publikováno v:
Neurobiology of Disease, Vol 23, Iss 1, Pp 190-197 (2006)
The brain levels of the endogenous excitotoxin quinolinic acid (QUIN) and its bioprecursor, the free radical generator 3-hydroxykynurenine (3-HK), are elevated in early stage Huntington disease (HD). We now examined the status of these metabolites in
Externí odkaz:
https://doaj.org/article/b993d28c31c845319dd537405eba5f0a
Autor:
Jacqueline Shehadeh, Herman B. Fernandes, Melinda M. Zeron Mullins, Rona K. Graham, Blair R. Leavitt, Michael R. Hayden, Lynn A. Raymond
Publikováno v:
Neurobiology of Disease, Vol 21, Iss 2, Pp 392-403 (2006)
Huntington disease (HD), caused by expansion >35 of a polyglutamine tract in huntingtin, results in degeneration of striatal medium spiny neurons (MSNs). Previous studies demonstrated mitochondrial dysfunction, altered intracellular calcium release,
Externí odkaz:
https://doaj.org/article/f0d4546f3e184a33b3bb9da4277700b8
Autor:
Rona K. Graham, Elizabeth J. Slow, Yu Deng, Nagat Bissada, Ge Lu, Jacqueline Pearson, Jacqueline Shehadeh, Blair R. Leavitt, Lynn A. Raymond, Michael R. Hayden
Publikováno v:
Neurobiology of Disease, Vol 21, Iss 2, Pp 444-455 (2006)
Huntington disease (HD) is a devastating neuropsychiatric disease caused by expansion of a trinucleotide repeat (CAG) in the HD gene. Neuropathological changes include the appearance of N-terminal huntingtin fragments, decreased brain weight and apop
Externí odkaz:
https://doaj.org/article/c47e1730cc914f90be9d86554a4eee34
Autor:
Majed Alotaibi, Melissa Lessard-Beaudoin, Kate Busch, Amal Loudghi, Pierrette Gaudreau, Rona K Graham
Publikováno v:
Experimental Aging Research. :1-16
In many neurological disorders, including Alzheimer disease, early olfactory dysfunction is observed.In order to determine if deficits in olfactory memory are present in the elderly and if olfactory dysfunction correlates with cognitive impairment in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7a86985859366ff9b5e14bc8a7616d
https://doi.org/10.1080/0361073x.2022.2160597
https://doi.org/10.1080/0361073x.2022.2160597
Autor:
Frédéric Calon, Laura M. Gonzalez, Mélissa Lessard-Beaudoin, Rona K. Graham, Majed AlOtaibi, Mélanie Plourde, Raphaël Chouinard-Watkins
Publikováno v:
European Journal of Neuroscience. 54:7092-7108
Olfactory dysfunction is observed in several neurological disorders including Mild Cognitive Impairment (MCI) and Alzheimer disease (AD). These deficits occur early and correlate with global cognitive performance, depression and degeneration of olfac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a185550f2c0507b547bad6f5924aa20c
https://doi.org/10.1111/ejn.15472
https://doi.org/10.1111/ejn.15472
Autor:
Gemma Camara, Majed Alotaibi, Melissa Lessard-Beaudoin, Kate Busch, Louis Gendron, Rona K. Graham
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 126:110775
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f71cf48bc72e91aeae0b5964c6cf301e
https://doi.org/10.1016/j.pnpbp.2023.110775
https://doi.org/10.1016/j.pnpbp.2023.110775