Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Rona G. Giffard"'
Autor:
Xiaoyun Sun, Ji-Hye Jung, Oiva Arvola, Michelle R. Santoso, Rona G. Giffard, Phillip C. Yang, Creed M. Stary
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
In the present study, we assessed efficacy of exosomes harvested from human and mouse stem cell cultures in protection of mouse primary astrocyte and neuronal cell cultures following in vitro ischemia, and against ischemic stroke in vivo. Cell media
Externí odkaz:
https://doaj.org/article/fc22a214743a4ce384c7fc1e105f6e75
Autor:
Creed M. Stary, Lijun Xu, Ludmilla A. Voloboueva, Marcela Alcántara-Hernández, Oiva J. Arvola, Juliana Idoyaga, Rona G. Giffard
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Recent studies demonstrate significant neuroimmune changes in postpartum females, a period that also carries an increased risk of stroke. Oxytocin, a major hormone upregulated in the brains of nursing mothers, has been shown to both modulate neuroinf
Externí odkaz:
https://doaj.org/article/4aca29d3bcae4baf802198a416021b02
Autor:
Yi-Bing Ouyang, Yu Lu, Sibiao Yue, Li-Jun Xu, Xiao-Xing Xiong, Robin E. White, Xiaoyun Sun, Rona G. Giffard
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 1, Pp 555-563 (2012)
MicroRNAs (miRNA) are short (~22 nt) single stranded RNAs that downregulate gene expression. Although recent studies indicate extensive miRNA changes in response to ischemic brain injury, there is currently little information on the roles of specific
Externí odkaz:
https://doaj.org/article/fc10a75e481741f99b6a5fec296e508c
Autor:
Carla M. Webster, Stephen Kelly, Maya A. Koike, Valerie Y. Chock, Rona G. Giffard, Midori A. Yenari
Publikováno v:
Neurobiology of Disease, Vol 33, Iss 2, Pp 301-312 (2009)
We previously showed that hypothermia attenuates inflammation in focal cerebral ischemia (FCI) by suppressing activating kinases of nuclear factor-kappa B (NFκB). Here we characterize the inflammatory response in global cerebral ischemia (GCI), and
Externí odkaz:
https://doaj.org/article/fcbfd275fecf4b7685897a3931d260f6
Autor:
Yi-Bing Ouyang, Rona G. Giffard
Publikováno v:
International Journal of Cell Biology, Vol 2012 (2012)
It is commonly believed that sustained elevations in the mitochondrial matrix Ca2+ concentration are a major feature of the intracellular cascade of lethal events during cerebral ischemia. The physical association between the endoplasmic reticulum (E
Externí odkaz:
https://doaj.org/article/ebee1757752f4f958033d2b8ccb20f87
Publikováno v:
Mitochondrion
Brain-enriched microRNA-338 (miR-338) is known to play a central role in brain mitochondrial function, however the role of miR-338 in stroke injury remains unknown. This study investigated the role of miR-338 in injury from transient focal cerebral i
Publikováno v:
The Journal of Neuroscience. 37:3072-3084
Neurogenesis is essential to brain development and plays a central role in the response to brain injury. Stroke and head trauma stimulate proliferation of endogenous neural stem cells (NSCs); however, the survival of young neurons is sharply reduced
Autor:
David J. Clark, Creed M. Stary, Anand N. Rao, Lijun Xu, Rona G. Giffard, Oiva Arvola, De-Yong Liang, Peyman Sahbaie, Yi-Bing Ouyang, Brian B. Griffiths
Publikováno v:
Neuromolecular Med
Mild traumatic brain injury (mTBI) can result in permanent impairment in memory and learning and may be a precursor to other neurological sequelae. Clinical treatments to ameliorate the effects of mTBI are lacking. Inhibition of microRNA-181a (miR-18
Publikováno v:
Mitochondrion. 30:248-254
Neurons in the cornu ammonis 1 (CA1) region of the hippocampus are vulnerable to cerebral ischemia, while dentate gyrus (DG) neurons are more resistant. This effect is mediated by local astrocytes, and may reflect differences in subregional hippocamp
Autor:
Haili Zhang, Rona G. Giffard, Dan Xu, Peyman Sahbaie, David L. Dill, Manhong Wu, Li Jun Xu, Gary Peltz, Ming Zheng, J. David Clark, Xiaoxing Xiong, Yuki Nishimura, Toshihiko Nishimura
Publikováno v:
Genetics. 203:599-609
Haloperidol is an effective antipsychotic agent, but it causes Parkinsonian-like extrapyramidal symptoms in the majority of treated subjects. To address this treatment-limiting toxicity, we analyzed a murine genetic model of haloperidol-induced toxic