The genetic architecture of helminth-specific immune responses in a wild population of Soay sheep (Ovis aries)

Autor: Jill G. Pilkington, Alexandra M. Sparks, Susan E. Johnston, Josephine M. Pemberton, Kathryn A. Watt, Rona Sinclair, Tom N. McNeilly, Daniel H. Nussey

Publikováno v: PLoS Genetics, Vol 15, Iss 11, p e1008461 (2019)
Sparks, A M, Watt, K, Sinclair, R, Pilkington, J G, Pemberton, J M, McNeilly, T N, Nussey, D H & Johnston, S E 2019, ' The genetic architecture of helminth-specific immune responses in a wild population of Soay sheep (Ovis aries) ', PLoS Genetics, vol. 15, no. 11, e1008461, pp. 1-29 . https://doi.org/10.1371/journal.pgen.1008461
PLoS Genetics

Much of our knowledge of the drivers of immune variation, and how these responses vary over time, comes from humans, domesticated livestock or laboratory organisms. While the genetic basis of variation in immune responses have been investigated in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce3c3d91a8ab7eacb3b688a54061e76
https://doaj.org/article/7036a201b27d400183b015f962a3d48b

Gastrointestinal nematode species diversity in Soay sheep kept in a natural environment without active parasite control

Autor: Rona Sinclair, Lynsey Melville, Fiona Kenyon, Kathryn A. Watt, Neil Sargison, Fiona Sargison, Daniel H. Nussey

Publikováno v: Sinclair, R, Melville, L, Sargison, F, Kenyon, F, Nussey, D, Watt, K & Sargison, N 2016, ' Gastrointestinal nematode species diversity in Soay sheep kept in a natural environment without active parasite control ', Veterinary Parasitology, vol. 227, pp. 1-7 . https://doi.org/10.1016/j.vetpar.2016.07.020

Molecular methods based on ITS2 sequence analysis were used to identify strongylid parasites and describe their diversity in a management intervention and anthelmintic drug treatment-free sheep flock. Fourteen different nematode parasite species were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d92d961a566da03aae67094e48ab79d
https://doi.org/10.1016/j.vetpar.2016.07.020

A candidate gene approach to study nematode resistance traits in naturally infected sheep

Autor: Hazel, Wilkie, Valentina, Riggio, Oswald, Matika, Louise, Nicol, Kathryn A, Watt, Rona, Sinclair, Alexandra M, Sparks, Daniel H, Nussey, Josephine M, Pemberton, Ross D, Houston, John, Hopkins

Publikováno v: Veterinary Parasitology

Highlights • SNPs within genes associated with the development of nematode resistance were sequenced. • The SNPs were segregating in two unrelated, domestic and feral, sheep breeds. • More samples are required to determine significant associati

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https://pubmed.ncbi.nlm.nih.gov/28807314