Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ron kleiner"'
Autor:
Rita C. Acúrcio, Ron Kleiner, Daniella Vaskovich‐Koubi, Bárbara Carreira, Yulia Liubomirski, Carolina Palma, Adva Yeheskel, Eilam Yeini, Ana S. Viana, Vera Ferreira, Carlos Araújo, Michael Mor, Natalia T. Freund, Eran Bacharach, João Gonçalves, Mira Toister‐Achituv, Manon Fabregue, Solene Matthieu, Capucine Guerry, Ana Zarubica, Sarit Aviel‐Ronen, Helena F. Florindo, Ronit Satchi‐Fainaro
Publikováno v:
Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)
Abstract The first approved vaccines for human use against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) are nanotechnology‐based. Although they are modular, rapidly produced, and can reduce disease severity, the currently availa
Externí odkaz:
https://doaj.org/article/b5734eacdf3b49c7be9c99d042cb5913
Autor:
Eilam Yeini, Paula Ofek, Sabina Pozzi, Nitzan Albeck, Dikla Ben-Shushan, Galia Tiram, Sapir Golan, Ron Kleiner, Ron Sheinin, Sahar Israeli Dangoor, Shlomit Reich-Zeliger, Rachel Grossman, Zvi Ram, Henry Brem, Thomas M. Hyde, Prerna Magod, Dinorah Friedmann-Morvinski, Asaf Madi, Ronit Satchi-Fainaro
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Glioma-associated microglia/macrophages are central drivers of brain tumor pathology. Here the authors characterize the role of the P-selectin/PSGL-1 axis in the cross-talk between glioblastoma cells and microglia/macrophages and show that the therap
Externí odkaz:
https://doaj.org/article/1f79e03ac9e64447af84689d42d725ab
Autor:
Barbara Carreira, Rita A. Acúrcio, Sabina Pozzi, Ron Kleiner, Liane I. Moura, Ana I. Matos, Daniela vaskovich, Carina Peres, Adelaide Fernandes, Sara Xapelli, Ronit Satchi-Fainaro, Helena F. Florindo
Publikováno v:
Cancer Research. 83:835-835
Sixty percent of melanoma patients present brain metastases, having low response rates to current systemic therapies, which do not prolong survival. New therapeutic options to address this clinical need are urgent. Here, we report the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edff0e471b62de015878db1b3c507d4e
https://doi.org/10.1158/1538-7445.am2023-835
https://doi.org/10.1158/1538-7445.am2023-835
Publikováno v:
Cancer Research. 83:3243-3243
Despite the remarkable efficiency of immune checkpoint modulators against primary and metastatic brain neoplasms, there is a low percentage of responders and clinical trials report severe immune-mediated side effects and disease relapse. An accumulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::911421bebbc46c4777c09cdb56480c42
https://doi.org/10.1158/1538-7445.am2023-3243
https://doi.org/10.1158/1538-7445.am2023-3243
Autor:
Carina Peres, Ana I. Matos, Neta Erez, Helena F. Florindo, Hila Doron, Sabina Pozzi, Eva Zupancic, João Conniot, Ana S. Viana, Pedro M. P. Gois, Liane I.F. Moura, Anna Scomparin, Steffen Jung, Ronit Satchi-Fainaro, Ron Kleiner, Eilam Yeini
Publikováno v:
Nature Nanotechnology. 14:891-901
A low response rate, acquired resistance and severe side effects have limited the clinical outcomes of immune checkpoint therapy. Here, we show that combining cancer nanovaccines with an anti-PD-1 antibody (αPD-1) for immunosuppression blockade and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af9ca2f830640d064f4e847823d6e93
https://doi.org/10.1038/s41565-019-0512-0
https://doi.org/10.1038/s41565-019-0512-0
Autor:
Rita C. Acúrcio, Helena F. Florindo, Carina Peres, Barbara Carreira, Daniella Vaskovich-Koubi, Sabina Pozzi, Ronit Satchi-Fainaro, Ana I. Matos, Liane I.F. Moura, Ron Kleiner
Publikováno v:
Advanced drug delivery reviews. 172
The remarkable success of targeted immunotherapies is revolutionizing cancer treatment. However, tumor heterogeneity and low immunogenicity, in addition to several tumor-associated immunosuppression mechanisms are among the major factors that have pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8881d13a21f0b23da1bc31fc623e27b1
https://pubmed.ncbi.nlm.nih.gov/33711401
https://pubmed.ncbi.nlm.nih.gov/33711401
Autor:
Daniella Vaskovich-Koubi, Ron kleiner, Anat Eldar-Boock, Sabina Pozzi, Dikla Dikla Ben-Shushan, Helena F. Florindo, Ronit Satchi-Fainaro
Publikováno v:
Cancer Research. 82:3520-3520
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death. Low response rate, acquired resistance, severe side effects, highly desmoplastic, and immunosuppressive microenvironment have limited the clinical outcomes o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a6de71740747717297e6318d9c08f8e
https://doi.org/10.1158/1538-7445.am2022-3520
https://doi.org/10.1158/1538-7445.am2022-3520
Autor:
Helena F. Florindo, Ronit Satchi-Fainaro, Anat Eldar-Boock, Dikla Ben-Shushan, Sabina Pozzi, Ron Kleiner, Daniella Vaskovich
Publikováno v:
Cancer Research. 81:1746-1746
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death. Low response rate, acquired resistance, severe side effects, highly desmoplastic and immunosuppressive microenvironment have limited the clinical outcomes of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b67c91d4401bc3838855bed1873f0c0
https://doi.org/10.1158/1538-7445.am2021-1746
https://doi.org/10.1158/1538-7445.am2021-1746
Autor:
Ron Kleiner, Daniella Vaskovich-Koubi, Anat Eldar-Boock, Helena F. Florindo, Eilam Yeini, Yulia Liubomirski, Sabina Pozzi, Galia Tiram, Ronit Satchi-Fainaro
Publikováno v:
Cancer Research. 81:714-714
Dendritic cells (DC) are antigen-presenting cells with an important role in the initiation and regulation of the innate and adaptive arms of the immune system. By efficient presentation of antigens, DC elicit an antigen-specific immune response. Ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::836a86b7a7135e0e30cfe26e253b1eaf
https://doi.org/10.1158/1538-7445.am2021-714
https://doi.org/10.1158/1538-7445.am2021-714
Autor:
Sabina Pozzi, Thomas M. Hyde, Sapir Golan, Prerna Magod, Dikla Ben-Shushan, Paula Ofek, Nitzan Albeck, Henry Brem, Galia Tiram, Asaf Madi, Ron Kleiner, Rachel Grossman, Dinorah Friedmann-Morvinski, Zvi Ram, Ronit Satchi-Fainaro, Ron Sheinin, Eilam Yeini, Shlomit Reich-Zeliger
Publikováno v:
Cancer Research. 81:2716-2716
Glioblastoma (GB) is an aggressive type of brain cancer with high mortality rate. It is a highly angiogenic tumor exhibiting an extremely invasive nature. As such, its brain microenvironment plays a crucial role in its progression. Microglia are the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3460203f8277f07136ae9090f2417832
https://doi.org/10.1158/1538-7445.am2021-2716
https://doi.org/10.1158/1538-7445.am2021-2716