Výsledky vyhledávání - "Ron T. McElmurry"

Rapid generation of Col7a1−/− mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells

Autor: Natasha Y. Frank, Mark A. Kluth, Elise N Durgin, Beau R. Webber, Wendy Mathews, Christopher J. Lees, Kyle T O'Connor, Mark J. Osborn, Jakub Tolar, Markus H. Frank, Cindy R. Eide, Branden S. Moriarity, Christoph Ganss, Ron T. McElmurry, Megan J. Riddle

Publikováno v: Laboratory investigation; a journal of technical methods and pathology

Recessive dystrophic epidermolysis bullosa (RDEB) is a debilitating and ultimately lethal blistering disease caused by mutations to the Col7a1−/− gene. Development of novel cell therapies for the treatment of RDEB would be fostered by having immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a567f891638a6b723a155c37d3ed52d
http://europepmc.org/articles/PMC5623156

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Abcg2-Expressing Side Population Cells Contribute to Cardiomyocyte Renewal through Fusion

Autor: John W. Elrod, Ron T. McElmurry, Yi Ren, Jonathan P. Lambert, Amritha Yellamilli, Steven R. Houser, Jop H. van Berlo, Daniel J. Garry, Sadia Mohsin, Jakub Tolar, Polina Gross

Publikováno v: FASEB J

The adult mammalian heart has a limited regenerative capacity. Therefore, identification of endogenous cells and mechanisms that contribute to cardiac regeneration is essential for the development of targeted therapies. The side population (SP) pheno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbc1e0e2f0861857bae7d110b16d68e
https://doi.org/10.1101/690339

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Thymic Epithelial Cell Support of Thymopoiesis Does Not Require

Autor: Kenneth I. Weinberg, Ron T. McElmurry, Georg A. Holländer, Yan Xing, Michelle J. Smith, Jakub Tolar, Heather E. Stefanski, Sarah L. Parker, Dullei Min, Christine A. Goetz, Bruce R. Blazar

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 201(11)

Age-related thymic involution is characterized by a decrease in thymic epithelial cell (TEC) number and function parallel to a disruption in their spatial organization, resulting in defective thymocyte development and proliferation as well as periphe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c016a72316e131330c79e046774918
https://pubmed.ncbi.nlm.nih.gov/30373854

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Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect

Autor: Jeffrey S. Miller, Peter Hinderlie, Bruce R. Blazar, Ron T. McElmurry, Martin Felices, Jakub Tolar, Laura Bendzick, Sami Chu, Melissa A. Geller, Alexander J. Lenvik

NK cell-based immunotherapies have been gaining traction in the clinic for treatment of cancer. IL-15 is currently being used in number of clinical trials to improve NK cell expansion and function. The objective of this study is to evaluate the effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6774155e7efcae69c3bb6353a54bba32
https://europepmc.org/articles/PMC5821201/

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Mesenchymal stromal cells inhibit murine syngeneic anti-tumor immune responses by attenuating inflammation and reorganizing the tumor microenvironment

Autor: Jaime F. Modiano, Donald Bellgrau, Ron T. McElmurry, Colleen L. Forster, Beth A. Lindborg, Jerome Schaack, Edward A. Zamora, Timothy O'Brien, Mitzi Lewellen, Jakub Tolar

Publikováno v: Cancer Immunology, Immunotherapy. 64:1449-1460

The potential of mesenchymal stromal cells (MSCs) to inhibit anti-tumor immunity is becoming increasingly well recognized, but the precise steps affected by these cells during the development of an anti-tumor immune response remain incompletely under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9283fa3f8862e607d401f0cd3934f75
https://doi.org/10.1007/s00262-015-1749-6

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CRISPR/Cas9-based genetic correction for recessive dystrophic epidermolysis bullosa

Autor: Amber N. McElroy, Ron T. McElmurry, Kirk Twaroski, Mark J. Osborn, Chong Jai Kim, Cindy R. Eide, Anthony P. DeFeo, Megan J. Riddle, Dharmeshkumar Patel, Bruce R. Blazar, Jakub Tolar, Christopher J. Lees, Lily Xia, Beau R. Webber, Cara-lin Lonetree

Publikováno v: NPJ Regenerative Medicine

Recessive dystrophic epidermolysis bullosa (RDEB) is a severe disorder caused by mutations to the COL7A1 gene that deactivate production of a structural protein essential for skin integrity. Haematopoietic cell transplantation can ameliorate some of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f82f52debdc56e9e73d36655bf6828
https://pubmed.ncbi.nlm.nih.gov/28250968

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Expansion and Homing of Adoptively Transferred Human Natural Killer Cells in Immunodeficient Mice Varies with Product Preparation and In Vivo Cytokine Administration: Implications for Clinical Therapy

Autor: Jeffrey S. Miller, Bruce R. Blazar, John E. Wagner, Jakub Tolar, David H. McKenna, Michael R. Verneris, Natalia Lapteva, Cliona M. Rooney, Ron T. McElmurry, Valarie McCullar, Julie M. Curtsinger

Publikováno v: Biology of Blood and Marrow Transplantation. 20:1252-1257

Natural killer (NK) cell efficacy correlates with in vivo proliferation, and we hypothesize that NK cell product manipulations may optimize this endpoint. Xenotransplantation was used to compare good manufacturing practice (GMP) grade freshly activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ca2fe0a5b4a398cbf7facdaf28f6af
https://doi.org/10.1016/j.bbmt.2014.05.004

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Angiotensin receptor blockade mediated amelioration of mucopolysaccharidosis type I cardiac and craniofacial pathology

Autor: Beau R. Webber, Elizabeth A. Braunlin, Benedikt Hallgrímsson, Ron T. McElmurry, Bruce R. Blazar, Mark J. Osborn, Kyle Rudser, Anna Petryk, Michael Muradian, Jakub Tolar, Anthony P. DeFeo

Mucopolysaccharidosis type I (MPS IH) is a lysosomal storage disease (LSD) caused by inactivating mutations to the alpha-L-iduronidase (IDUA) gene. Treatment focuses on IDUA enzyme replacement and currently employed methods can be non-uniform in thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd39e0abef84d134f8a712784df3d6e
https://europepmc.org/articles/PMC5335863/

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miR-29 Regulates Type VII Collagen in Recessive Dystrophic Epidermolysis Bullosa

Autor: Ron T. McElmurry, D. Muldoon, Jakub Tolar, Wendy Mathews, Michael J Vanden Oever

Publikováno v: The Journal of investigative dermatology. 136(10)

Recessive dystrophic epidermolysis bullosa (RDEB) is a complex inherited skin disorder caused by loss-of-function mutations in the COL7A1 gene. For an effective treatment of this disorder to be realized, both a thorough understanding of the regulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48daa29fba5d4ab452795a1995eaa33
https://pubmed.ncbi.nlm.nih.gov/27328306

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