Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Ron R Kopito"'
Autor:
Kirby M Donnelly, Olivia R DeLorenzo, Aprem DA Zaya, Gabrielle E Pisano, Wint M Thu, Liqun Luo, Ron R Kopito, Margaret M Panning Pearce
Publikováno v:
eLife, Vol 9 (2020)
Emerging evidence supports the hypothesis that pathogenic protein aggregates associated with neurodegenerative diseases spread from cell to cell through the brain in a manner akin to infectious prions. Here, we show that mutant huntingtin (mHtt) aggr
Externí odkaz:
https://doaj.org/article/5f26dfbee6a846ff8b36481bb93cc2a8
Autor:
Adi Ben Yehuda, Marwa Risheq, Ofra Novoplansky, Kirill Bersuker, Ron R Kopito, Michal Goldberg, Michael Brandeis
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169054 (2017)
Deposition of ubiquitin conjugates on inclusion bodies composed of protein aggregates is a definitive cytopathological hallmark of neurodegenerative diseases. We show that accumulation of ubiquitin on polyQ IB, associated with Huntington's disease, i
Externí odkaz:
https://doaj.org/article/186781d2e99f40edb3fb2b407ae9c90d
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54541 (2013)
An apparatus that combines dynamic light scattering and Thioflavin T fluorescence detection is used to simultaneously probe fibril formation in polyglutamine peptides, the aggregating subunit associated with Huntington's disease, in vitro. Huntington
Externí odkaz:
https://doaj.org/article/adc6b5f3a9714d63bb81864ae90856cc
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32956 (2012)
Disruption of the polyubiquitin gene Ubc leads to a defect in fetal liver development, which can be partially rescued by increasing the amount of ubiquitin. However, it is still not known why Ubc is required for fetal liver development and the nature
Externí odkaz:
https://doaj.org/article/7cb365735f824e69bd5bdaa85da517c5
Autor:
William T Jackson, Thomas H Giddings, Matthew P Taylor, Sara Mulinyawe, Marlene Rabinovitch, Ron R Kopito, Karla Kirkegaard
Publikováno v:
PLoS Biology, Vol 3, Iss 5, p e156 (2005)
Infection of human cells with poliovirus induces the proliferation of double-membraned cytoplasmic vesicles whose surfaces are used as the sites of viral RNA replication and whose origin is unknown. Here, we show that several hallmarks of cellular au
Externí odkaz:
https://doaj.org/article/8f89b59f2b904086a4019cd67e4a881f
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Ribosomes that stall while translating cytosolic proteins are incapacitated by incomplete nascent chains, termed “arrest peptides” (APs) that are destroyed by the ubiquitin proteasome system (UPS) via a process known as the ribosome-associated qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2688da735a628ee0134ec99e37633243
https://doi.org/10.1073/pnas.2220340120
https://doi.org/10.1073/pnas.2220340120
Autor:
Joshua J Peter, Helge M Magnussen, Paul A DaRosa, David Millrine, Stephen P Matthews, Frederic Lamoliatte, Ramasubramanian Sundaramoorthy, Ron R Kopito, Yogesh Kulathu
Publikováno v:
The EMBO Journal. 41
Protein UFMylation, i.e., post-translational modification with ubiquitin-fold modifier 1 (UFM1), is essential for cellular and endoplasmic reticulum homeostasis. Despite its biological importance, we have a poor understanding of how UFM1 is conjugate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f13c92b89b4f7e58893f4e768a971d
https://doi.org/10.15252/embj.2022111015
https://doi.org/10.15252/embj.2022111015
Autor:
Melissa A. Roberts, Kirandeep K. Deol, Mike Lange, Dara E. Leto, Alyssa J. Mathiowetz, Julian Stevenson, Sayed Hadi Hashemi, David W. Morgens, Emilee Easter, Kartoosh Heydari, Mike A. Nalls, Michael C. Bassik, Martin Kampmann, Ron R. Kopito, Faraz Faghri, James A. Olzmann
Lipid droplets (LDs) are lipid storage organelles that consist of a central core of neutral lipids surrounded by a phospholipid monolayer decorated with a unique set of integral and peripheral proteins. Invariably, at least one member of the perilipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2b8d123d58171067b82812f3e8c603f
https://doi.org/10.1101/2022.08.27.505556
https://doi.org/10.1101/2022.08.27.505556
Autor:
Sven Lyschik, Anna A. Lauer, Tanja Roth, Daniel Janitschke, Markus Hollander, Thorsten Will, Tobias Hartmann, Ron R. Kopito, Volkhard Helms, Marcus O. W. Grimm, Bianca Schrul
Publikováno v:
Frontiers in Cell and Developmental Biology. 10
Cellular lipid metabolism is tightly regulated and requires a sophisticated interplay of multiple subcellular organelles to adapt to changing nutrient supply. PEX19 was originally described as an essential peroxisome biogenesis factor that selectivel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a280750621f55c385689ea85ea17a95
https://doi.org/10.3389/fcell.2022.859052
https://doi.org/10.3389/fcell.2022.859052
Autor:
Joshua J. Peter, Helge M. Magnussen, Paul Anthony DaRosa, David Millrine, Stephen P Matthews, Frederic Lamoliatte, Ramasubramanian Sundaramoorthy, Ron R Kopito, Yogesh Kulathu
Protein UFMylation is emerging as a posttranslational modification essential for endoplasmic reticulum and cellular homeostasis. Despite its biological importance, we have a poor understanding of how UFM1 is conjugated onto substrates. Here, we use a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3819ab41288e8e19a2c2323d5d08546
https://doi.org/10.1101/2022.01.31.478489
https://doi.org/10.1101/2022.01.31.478489