Safety and immunogenicity of NVX-CoV2373 (TAK-019) vaccine in healthy Japanese adults: Interim report of a phase I/II randomized controlled trial

Autor: Taisei Masuda, Kyoko Murakami, Kenkichi Sugiura, Sho Sakui, Ron P Schuring, Mitsuhiro Mori

Publikováno v: Vaccine. 40(24)

We evaluated the safety and immunogenicity of NVX-CoV2373, a recombinant SARS-CoV-2 nanoparticle vaccine, in healthy Japanese participants.This phase 1/2, randomized, observer-blind, placebo-controlled trial conducted in Japan (two sites), enrolled h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc9e9736f49ec28bc98b5f00bd37cce
https://pubmed.ncbi.nlm.nih.gov/35501178

Preventing nerve function impairment in leprosy: validation and updating of a prediction rule.

Autor: Ron P Schuring, Jan H Richardus, Ewout W Steyerberg, David Pahan, William R Faber, Linda Oskam

Publikováno v: PLoS Neglected Tropical Diseases, Vol 2, Iss 8, p e283 (2008)

BACKGROUND: To validate and update a prediction rule for estimating the risk of leprosy-related nerve function impairment (NFI). METHODOLOGY/PRINCIPAL FINDINGS: Prospective cohort using routinely collected data, in which we determined the discriminat

Externí odkaz: https://doaj.org/article/91901f9ed44642d9beecee11b04999e8

Physical Distance, Genetic Relationship, Age, and Leprosy Classification Are Independent Risk Factors for Leprosy in Contacts of Patients with Leprosy

Autor: Jan Hendrik Richardus, Linda Oskam, F. Johannes Moet, David Pahan, Ron P. Schuring

Publikováno v: Journal of Infectious Diseases, 193(3), 346-353. Oxford University Press

Background. Close contacts of patients with leprosy have a higher risk of developing leprosy. Several risk factors have been identified, including genetic relationship and physical distance. Their independent contributions to the risk of developing l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9362005e3e0aa02b8d53d89368cf86bd
https://doi.org/10.1086/499278

Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions

Autor: Linda Oskam, Jan Hendrik Richardus, Ron P. Schuring, Ralf R. Schumann, David Pahan, William R. Faber, Lutz Hamann

Publikováno v: Journal of infectious diseases, 199(12), 1816-1819. Oxford University Press
Journal of Infectious Diseases, 199(12), 1816-1819. Oxford University Press

We investigated the association between a polymorphism of a key innate immunity receptor, Toll-like receptor 1 (TLR1) N248S, and susceptibility to leprosy and its clinical presentation. TLR1 N248S has been shown elsewhere to diminish TLR1 signaling a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4ef4593565a39403db6f17743d21f6
https://pubmed.ncbi.nlm.nih.gov/19456232

Low frequency of the TIRAP S180L polymorphism in Africa, and itspotential role in malaria, sepsis, and leprosy.

Publikováno v: BMC Medical Genetics. 2009, Vol. 10, p65-70. 6p.