CT-based finite element simulating spatial bone damage accumulation predicts metastatic human vertebrae strength and stiffness

Autor: Zahra Soltani, Michelle Xu, Raul Radovitzky, Marc A. Stadelmann, David Hackney, Ron N. Alkalay

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)

Introduction: Pathologic vertebral fractures are devastating for patients with spinal metastases. However, the mechanical process underlying these fractures is poorly understood, limiting physician’s ability to predict which vertebral bodies will f

Externí odkaz: https://doaj.org/article/4432fe90d4744d1c8050df28e4bbf634

Improved estimates of strength and stiffness in pathologic vertebrae with bone metastases using CT-derived bone density compared with radiographic bone lesion quality classification

Autor: Ron N. Alkalay, Marc A. Stadelmann, Michael W. Groff, David B. Hackney, Umesh Mektar, Nicolas Theumann, Roger B. Davis, Sven Hoppe, Florian M. Buck

Publikováno v: J Neurosurg Spine

OBJECTIVE The aim of this study was to compare the ability of 1) CT-derived bone lesion quality (classification of vertebral bone metastases [BM]) and 2) computed CT-measured volumetric bone mineral density (vBMD) for evaluating the strength and stif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d191721694518b00ea78e088650b9178
https://doi.org/10.3171/2021.2.spine202027

Finite element models can reproduce the effect of nucleotomy on the multi-axial compliance of human intervertebral discs

Autor: Ghislain Bernard Maquer, Ron N. Alkalay, Philippe K. Zysset, Peter Vermathen, Sven Hoppe, Roland Stocker, Marc A. Stadelmann

Publikováno v: Stadelmann, Marc André; Stocker, Roland; Maquer, Ghislain; Hoppe, Sven; Vermathen, Peter; Alkalay, Ron N.; Zysset, Philippe (2020). Finite element models can reproduce the effect of nucleotomy on the multi-axial compliance of human intervertebral discs. Computer methods in biomechanics and biomedical engineering, 23(13), pp. 934-944. Taylor & Francis 10.1080/10255842.2020.1773808
Comput Methods Biomech Biomed Engin

Intervertebral disc (IVD) degeneration is a cell-mediated response to progressive structural failure that is associated with chronic back pain. Due to its high socio-economic impact, numerous models have been proposed to investigate disc degeneration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6279d2942308bd32a572a4b5896c224
https://doi.org/10.1080/10255842.2020.1773808

Conventional finite element models estimate the strength of metastatic human vertebrae despite alterations of the bone's tissue and structure

Autor: Philippe K. Zysset, Sven Hoppe, Christopher Lenherr, Dieter D. Bosshardt, Florian M. Buck, Denis Schenk, Marc A. Stadelmann, Nicolas Theumann, Ghislain Bernard Maquer, Ron N. Alkalay

Publikováno v: Bone
Stadelmann, Marc A.; Schenk, Denis E.; Maquer, Ghislain; Lenherr, Christopher; Buck, Florian M; Bosshardt, Dieter; Hoppe, Sven; Theumann, Nicolas; Alkalay, Ron N; Zysset, Philippe K. (2020). Conventional finite element models estimate the strength of metastatic human vertebrae despite alterations of the bone's tissue and structure. Bone, 141(115598), p. 115598. Elsevier 10.1016/j.bone.2020.115598

INTRODUCTION Pathologic vertebral fractures are a major clinical concern in the management of cancer patients with metastatic spine disease. These fractures are a direct consequence of the effect of bone metastases on the anatomy and structure of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86356004d1fec99be09c7468134509ee

Mechanical assessment of the effects of metastatic lytic defect on the structural response of human thoracolumbar spine

Autor: Timothy P. Harrigan, Ron N. Alkalay

Publikováno v: Journal of Orthopaedic Research. 34:1808-1819

To investigate the effects of a clinical lytic defect on the structural response of human thoracolumbar functional spinal unit. A novel CT-compatible mechanical test system was used to image the deformation of a T12-L1 motion segment and measure the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6f7c2eb27bca2966c809c0d2557d367
https://doi.org/10.1002/jor.23154