Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice

Autor: Raffaella Rossin, Ron M. Versteegen, Jeremy Wu, Alisher Khasanov, Hans J. Wessels, Erik J. Steenbergen, Wolter ten Hoeve, Henk M. Janssen, Arthur H. A. M. van Onzen, Peter J. Hudson, Marc S. Robillard

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Current antibody-drug conjugates (ADCs) target internalising receptors on cancer cells. Here, the authors report the development and in vivo validation of a non-internalising ADC with the capacity to target cancer cells and release its therapeutic ca

Externí odkaz: https://doaj.org/article/b6e9e26c80024b1e84795b448f5f9b65

Bioorthogonal Tetrazine Carbamate Cleavage by Highly Reactive trans-Cyclooctene

Autor: Jeremy Wu, Henk M. Janssen, Marc S. Robillard, Wolter ten Hoeve, Raffaella Rossin, Ivo A. W. Filot, Freek J. M. Hoeben, Tong Zhu, Ron M. Versteegen, Arthur H. A. M. van Onzen, Peter J. Hudson

Publikováno v: Journal of the American Chemical Society, 142(25), 10955-10963. American Chemical Society

The high reaction rate of the 'click-to-release' reaction between allylic substituted trans-cyclooctene and tetrazine has enabled exceptional control over chemical and biological processes. Here we report the development of a new bioorthogonal cleava

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046093c090025229ecceb13026d94ddc
http://www.scopus.com/inward/record.url?scp=85087007014&partnerID=8YFLogxK

Bioorthogonal Tetrazine Carbamate Cleavage by Highly Reactive

Autor: Arthur H A M, van Onzen, Ron M, Versteegen, Freek J M, Hoeben, Ivo A W, Filot, Raffaella, Rossin, Tong, Zhu, Jeremy, Wu, Peter J, Hudson, Henk M, Janssen, Wolter, Ten Hoeve, Marc S, Robillard

Publikováno v: Journal of the American Chemical Society. 142(25)

The high rate of the 'click-to-release' reaction between an allylic substituted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6bb924ffa0c797b12707dd6ef07c3450
https://pubmed.ncbi.nlm.nih.gov/32453557

An all-aromatic polypyridine: Monomer and polymer synthesis; Film formation and crosslinking; A candidate fuel cell membrane

Autor: Doetze Jakob Sikkema, Ger Jan Kemperman, Ron M. Versteegen, Jos B.M. Rewinkel, Menno Koeman, Ben Boere, Ferry Brands, Maarten J. Pouderoijen, Henk M. Janssen

Publikováno v: Journal of Power Sources, 379, 234-239. Elsevier

2,6-di (3-pyridyl)phenol and the title polymer are synthesized at 1 kg scale. Polymer is processed and crosslinked without the introduction of non-aromatic moieties after shaping into membranes. Attractive proton conduction, at high temperature (140�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca01efc93289e14672c91375ab8c117
https://doi.org/10.1016/j.jpowsour.2018.01.062

Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice

Autor: Jeremy Wu, Alisher Khasanov, Peter J. Hudson, Ron M. Versteegen, Wolter ten Hoeve, Henk M. Janssen, Raffaella Rossin, Arthur H. A. M. van Onzen, Erik J. Steenbergen, Marc S. Robillard, Hans J. C. T. Wessels

Publikováno v: Nature Communications, 9(1):1484. Nature Publishing Group
Nature Communications, 9, pp.
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, 9,
Nature Communications

Current antibody-drug conjugates (ADCs) target internalising receptors on cancer cells leading to intracellular drug release. Typically, only a subset of patients with solid tumours has sufficient expression of such a receptor, while there are suitab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77b0775e4d21e2277afc8b9588b3e4a
https://research.tue.nl/nl/publications/e37d6b6f-65df-4929-8563-a399982085ef