Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ron M, Lawrence"'
Autor:
Stephanie L. Gresham, P. Roberts, Federico M. Gomez-de-las-Heras, Charles B. Davis, Timothy K. Hart, Ron M. Lawrence, Neil G. Berry, Paul M. O'Neill, Domingo Gargallo, B. Kevin Park, Stephen Hindley, Patrick G. Bray, Giancarlo A. Biagini, James L. Maggs, Amira Mukhtar, Peter Gibbons, P. A. Winstanley, Richard A. Brigandi, Paul A. Stocks, Alison E. Shone, Ramesh Bambal, Martin Bates, Richard P. Bonar-Law, Stephen A. Ward
Publikováno v:
Journal of Medicinal Chemistry. 52:1408-1415
N-tert-Butyl isoquine (4) (GSK369796) is a 4-aminoquinoline drug candidate selected and developed as part of a public-private partnership between academics at Liverpool, MMV, and GSK pharmaceuticals. This molecule was rationally designed based on che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35436c97f1a67b9100d3dc4b1c06355
https://doi.org/10.1021/jm8012618
https://doi.org/10.1021/jm8012618
Publikováno v:
The Journal of Organic Chemistry. 70:5665-5670
[reaction: see text] A protocol for the enantioselective nitro-Mannich coupling between alkyl, aryl, and heterocyclic p-methoxybenzylimines and trimethylsilylnitropropanate catalyzed by a chiral tBu-BOX Cu(II) catalyst is described. It uses the lowes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3420e07ac8af5ee6dc37d2978892fa0
https://doi.org/10.1021/jo050762i
https://doi.org/10.1021/jo050762i
Autor:
Peter W. Scott, Åsa Sjolin, Ron M. Lawrence, Jason W. B. Cooke, Roger Barrett, Darren Caine, Kevin S. Cardwell
Publikováno v:
Tetrahedron: Asymmetry. 14:3627-3631
A convenient, efficient and cost-effective two-stage synthesis of benzyl (3R)-3-amino-2-oxo-1-pyrrolidinecarboxylate (2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]butanediote (2:1) via a crystallisation-induced dynamic resolution process is reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7e3fe7453d939e07fcbd98ec8435bb1
https://doi.org/10.1016/s0957-4166(03)00546-9
https://doi.org/10.1016/s0957-4166(03)00546-9
Autor:
Peter Szeto, Timothy Gallagher, Ron M. Lawrence, Hannah Woodward, John F. Bower, Andrew Williams
Publikováno v:
Organicbiomolecular chemistry. 5(16)
Five and six ring α-phosphono lactams 14–20 are available by reaction of 1,2- and 1,3-cyclic sulfamidates respectively with enolates derived from ethyl dialkylphosphonoacetates 3 and 4. Subsequent Wadsworth–Emmons olefination provides the enanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07177a39eeab0309c65a11b81400e1c
https://pubmed.ncbi.nlm.nih.gov/18019539
https://pubmed.ncbi.nlm.nih.gov/18019539
Autor:
John F. Bower, Ron M. Lawrence, Suda Chakthong, Timothy Gallagher, Andrew Williams, Jakub Švenda, Peter Szeto
Publikováno v:
ChemInform. 37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caaa33f30233b6a6cfe420d2cada6290
https://doi.org/10.1002/chin.200641098
https://doi.org/10.1002/chin.200641098
Autor:
Jakub Švenda, Suda Chakthong, Ron M. Lawrence, Peter Szeto, Andrew Williams, Timothy Gallagher, John F. Bower
Publikováno v:
Organicbiomolecular chemistry. 4(10)
A structurally representative series of 1,2- and 1,3-cyclic sulfamidates react with enolates derived from methyl alpha-phenylthioacetate 9b to give 5- and 6-substituted alpha-phenylthio lactams 20-24. These products provide, via the corresponding sul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6be2136c121384b4fa647d222613516
https://pubmed.ncbi.nlm.nih.gov/16688332
https://pubmed.ncbi.nlm.nih.gov/16688332
Autor:
Peter Szeto, Jonathan P. H. Charmant, Andrew Williams, John F. Bower, Ron M. Lawrence, Timothy Gallagher, Jakub Švenda
Publikováno v:
ChemInform. 36
A structurally diverse series of mono- and disubstituted 1,2- and 1,3-cyclic sulfamidates react with stabilized enolates, including malonate and phosphonoacetate variants, to provide, after lactamization, substituted and α-functionalized pyrrolidino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a998144b45a014a853d2e5d830117ad
https://doi.org/10.1002/chin.200514117
https://doi.org/10.1002/chin.200514117
Autor:
John F, Bower, Jakub, Svenda, Andrew J, Williams, Jonathan P H, Charmant, Ron M, Lawrence, Peter, Szeto, Timothy, Gallagher
Publikováno v:
Organic letters. 6(25)
[reaction: see text] A structurally diverse series of mono- and disubstituted 1,2- and 1,3-cyclic sulfamidates react with stabilized enolates, including malonate and phosphonoacetate variants, to provide, after lactamization, substituted and alpha-fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::92d38b1e130897e3a1b9a4eeb96ba70a
https://pubmed.ncbi.nlm.nih.gov/15575671
https://pubmed.ncbi.nlm.nih.gov/15575671
Publikováno v:
Organic letters. 5(6)
[reaction: see text] 1,2-Cyclic sulfamidates undergo regiospecific nucleophilic displacement with either methyl thioglycolate or alpha-amino esters, followed by lactamization (thermal, base-mediated, or cyanide-catalyzed), to give thiomorpholin-3-one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5730e6a4e3ddd4790169bb2a92178f
https://pubmed.ncbi.nlm.nih.gov/12633078
https://pubmed.ncbi.nlm.nih.gov/12633078
Publikováno v:
Synfacts. 2005:0141-0141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5b65725acc3abebecfba09ce678967b
https://doi.org/10.1055/s-2005-872185
https://doi.org/10.1055/s-2005-872185