Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Ron M, Kerkhoven"'
Autor:
Yibo Xue, Brian Meehan, Elizabeth Macdonald, Sriram Venneti, Xue Qing D. Wang, Leora Witkowski, Petar Jelinic, Tim Kong, Daniel Martinez, Geneviève Morin, Michelle Firlit, Atefeh Abedini, Radia M. Johnson, Regina Cencic, Jay Patibandla, Hongbo Chen, Andreas I. Papadakis, Aurelie Auguste, Iris de Rink, Ron M. Kerkhoven, Nicholas Bertos, Walter H. Gotlieb, Blaise A. Clarke, Alexandra Leary, Michael Witcher, Marie-Christine Guiot, Jerry Pelletier, Josée Dostie, Morag Park, Alexander R. Judkins, Ralf Hass, Douglas A. Levine, Janusz Rak, Barbara Vanderhyden, William D. Foulkes, Sidong Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is driven by SMARCA4 loss. Here the authors demonstrate that SCCOHT cells are highly sensitive to CDK4/6 inhibition and provide mechanistic insights, whereby this druggable vulnerability
Externí odkaz:
https://doaj.org/article/a9bfc57c02f44dfc91dacd68ff8a6a66
Autor:
Annegien Broeks, Sarah Warren, Pia Kvistborg, Richard A Scolyer, Esmee P Hoefsmit, Elisa A Rozeman, Trieu My Van, Petros Dimitriadis, Oscar Krijgsman, Jordan W Conway, Jacqueline E van der Wal, Steven L C Ketelaars, Kaspar Bresser, Ron M Kerkhoven, Jason W Reeves, Ellen W Kapiteijn, Daniel S Peeper, Ton N M Schumacher
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background The profound disparity in response to immune checkpoint blockade (ICB) by cutaneous melanoma (CM) and uveal melanoma (UM) patients is not well understood. Therefore, we characterized metastases of CM and UM from the same metastatic site (l
Externí odkaz:
https://doaj.org/article/57566697358f40ef905dd40c8195aef6
Autor:
Marc J. van de Vijver, Brigitte Sigal-Zafrani, Emmanuel Barillot, Harry Bartelink, Alain Fourquet, Rim Hadhri, Philippe Hupé, Ron M. Kerkhoven, Daoud Sie, Laurent Jacob, Bas Kreike, Kevin Bleakley, Hans Halfwerk, Marc A. Bollet, Nicolas Servant
Purpose: A gene expression signature, predictive for local recurrence after breast-conserving treatment, has previously been identified from a series of 165 young patients with breast cancer. We evaluated this signature on both another platform and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dac4bb284a408b0109451c08275aa37
https://doi.org/10.1158/1078-0432.c.6520737.v1
https://doi.org/10.1158/1078-0432.c.6520737.v1
Autor:
Marc J. van de Vijver, Brigitte Sigal-Zafrani, Emmanuel Barillot, Harry Bartelink, Alain Fourquet, Rim Hadhri, Philippe Hupé, Ron M. Kerkhoven, Daoud Sie, Laurent Jacob, Bas Kreike, Kevin Bleakley, Hans Halfwerk, Marc A. Bollet, Nicolas Servant
PDF file - 203K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44014ff9423e59c5e3b98cd05224296c
https://doi.org/10.1158/1078-0432.22446390
https://doi.org/10.1158/1078-0432.22446390
Autor:
A.C.J. van Akkooi, Judith M. Versluis, Christian U. Blank, Charlotte L. Zuur, Elisa A. Rozeman, Willem M.C. Klop, Esmée P. Hoefsmit, Lindsay G Grijpink-Ongering, María Jesús González González, Sandra Adriaansz, Robyn P. M. Saw, Sydney Ch'ng, Sten Cornelissen, J Stretch, Annegien Broeks, Ton N. Schumacher, A A Torres Acosta, Hanna Eriksson, Ron M. Kerkhoven, B.A. van de Wiel, Petros Dimitriadis, Richard A. Scolyer, Oscar Krijgsman, Daniel S. Peeper, J.B.A.G. Haanen, Omgo E. Nieweg, Karolina Sikorska, Kerwin F. Shannon, Georgina V. Long, W.J. van Houdt, A.M. Menzies, H. Mallo, Irene L.M. Reijers, Andrew J. Spillane
Publikováno v:
Nature Medicine. 27:256-263
Neoadjuvant ipilimumab plus nivolumab showed high pathologic response rates (pRRs) in patients with macroscopic stage III melanoma in the phase 1b OpACIN ( NCT02437279 ) and phase 2 OpACIN-neo ( NCT02977052 ) studies1,2. While the results are promisi
Autor:
Bingtao Hao, Heinz Jacobs, Colin Pritchard, Martijn van Baalen, Peter H.L. Krijger, Ron M. Kerkhoven, Iris de Rink, Mir Farshid Alemdehy, Muhammad Assad Aslam, Ika Nurzijah, Fitriari Izzatunnisa Muhaimin, Jane A. Skok, Paul C.M. van den Berk
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Immunoglobulin heavy chain checkpoint (IgHCC) is a critical step during early B cell development. The role of immunoglobulin heavy chain (IgHC) at this step is well established. However, with the expanding knowledge of RNA in regulating
Autor:
Oscar Krijgsman, Patricia Gonzalez, Olga Balagué Ponz, Margaretha G.M. Roemer, Stefanie Slot, Annegien Broeks, Linde Braaf, Ron M. Kerkhoven, Freek Bot, Krijn van Groningen, Max Beijert, Bauke Ylstra, Daphne de Jong
Publikováno v:
Haematologica, Vol 98, Iss 12 (2013)
Nodal marginal zone lymphoma is a poorly defined entity in the World Health Organization classification, based largely on criteria of exclusion and the diagnosis often remains subjective. Follicular lymphoma lacking t(14;18) has similar characteristi
Externí odkaz:
https://doaj.org/article/cc708e71c3ab433e9e8f1bc542061c44
Autor:
A.M. Menzies, B.A. van de Wiel, J.B.A.G. Haanen, Judith M. Versluis, Ron M. Kerkhoven, Acj van Akkooi, Christian U. Blank, Elisa A. Rozeman, Carolien Bierman, Ilm Reijers, W.J. van Houdt, Georgina V. Long, Oscar Krijgsman, Annegien Broeks, Hanna Eriksson, Richard A. Scolyer, Andrew J. Spillane, T.N. Schumacher, Rpm Saw, Petros Dimitriadis, Karolina Sikorska, María Jesús González González, Esmée P. Hoefsmit
Publikováno v:
Live Talks.
Background Before adjuvant checkpoint inhibition the 5-year overall survival (OS) rate was poor ( Materials and Methods The phase 1b OpACIN trial included 20 stage IIIB/IIIC melanoma patients, which were randomized to receive IPI 3 mg/kg plus NIVO 1
Autor:
Marc A Hogenbirk, Marinus R Heideman, Arno Velds, Paul C M van den Berk, Ron M Kerkhoven, Bas van Steensel, Heinz Jacobs
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69815 (2013)
The Aicda locus encodes the activation induced cytidine deaminase (AID) and is highly expressed in germinal center (GC) B cells to initiate somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes. Besides these I
Externí odkaz:
https://doaj.org/article/4f3946697d894dee97a6365ed48f3ee5
Autor:
Christian U. Blank, Elisa A. Rozeman, Ines Pires da Silva, Esmée P. Hoefsmit, Kaspar Bresser, Annegien Broeks, Ton N. Schumacher, Ellen Kapiteijn, Richard A. Scolyer, Trieu-My Van, Jason Reeves, Oscar Krijgsman, Daniel S. Peeper, Steven L. C. Ketelaars, Jordan Conway, Ron M. Kerkhoven, Jacqueline E. van der Wal, Georgina V. Long, Sarah Warren, Petros Dimitriadis, Pia Kvistborg
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, 8(2). BMJ PUBLISHING GROUP
Journal for ImmunoTherapy of Cancer
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, 8(2). BMJ PUBLISHING GROUP
Journal for ImmunoTherapy of Cancer
BackgroundThe profound disparity in response to immune checkpoint blockade (ICB) by cutaneous melanoma (CM) and uveal melanoma (UM) patients is not well understood. Therefore, we characterized metastases of CM and UM from the same metastatic site (li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104977900a329903a1fe0ba46dec9971
https://doi.org/10.1136/jitc-2020-001501
https://doi.org/10.1136/jitc-2020-001501