Výsledky vyhledávání

Phage-based biocontrol strategies and their application in agriculture and aquaculture

Autor: Ron L. Dy, Peter C. Fineran, Luciano A. Rigano

Publikováno v: Biochemical Society Transactions. 46:1605-1613

Meeting global food demands for a growing human population with finite natural resources is a major challenge. Aquaculture and agriculture are critical to satisfy food requirements, yet suffer significant losses from bacterial diseases. Therefore, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee832c5ea880ccd9ea6a6cba45b3add
https://doi.org/10.1042/bst20180178

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Akademický článek

Cytotoxic chromosomal targeting by CRISPR/Cas systems can reshape bacterial genomes and expel or remodel pathogenicity islands.

Autor: Reuben B Vercoe, James T Chang, Ron L Dy, Corinda Taylor, Tamzin Gristwood, James S Clulow, Corinna Richter, Rita Przybilski, Andrew R Pitman, Peter C Fineran

Publikováno v: PLoS Genetics, Vol 9, Iss 4, p e1003454 (2013)

In prokaryotes, clustered regularly interspaced short palindromic repeats (CRISPRs) and their associated (Cas) proteins constitute a defence system against bacteriophages and plasmids. CRISPR/Cas systems acquire short spacer sequences from foreign ge

Externí odkaz: https://doaj.org/article/1ca8c083e7304659ae3af02bdfbfea2b

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AbiEi binds cooperatively to the Type IV abiE toxin-antitoxin operator via a positively-charged surface and causes DNA bending and negative autoregulation

Autor: Anne Ilse Maria Vogel, Ron L. Dy, Simon A. Jackson, Tim R. Blower, Peter C. Fineran, Robert D. Fagerlund, Hannah G. Hampton

Publikováno v: Journal of molecular biology, 2018, Vol.430(8), pp.1141-1156 [Peer Reviewed Journal]

Bacteria resist phage infection using multiple strategies, including CRISPR-Cas and abortive infection (Abi) systems. Abi systems provide population-level protection from phage predation, via “altruistic” cell suicide. It has recently been shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e639405caee9c1ed428527c12ad603ce
http://dro.dur.ac.uk/24233/

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Remarkable Mechanisms in Microbes to Resist Phage Infections

Autor: Ron L. Dy, George P. C. Salmond, Corinna Richter, Peter C. Fineran

Publikováno v: Annual Review of Virology. 1:307-331

Bacteriophages (phages) specifically infect bacteria and are the most abundant biological entities on Earth. The constant exposure to phage infection imposes a strong selective pressure on bacteria to develop viral resistance strategies that promote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f562979999eec8c82dea107dea37991e
https://doi.org/10.1146/annurev-virology-031413-085500

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A widespread bacteriophage abortive infection system functions through a Type IV toxin–antitoxin mechanism

Autor: Koen Semeijn, Ron L. Dy, Peter C. Fineran, Rita Przybilski, George P. C. Salmond

Publikováno v: Nucleic Acids Research

Bacterial abortive infection (Abi) systems are ‘altruistic’ cell death systems that are activated by phage infection and limit viral replication, thereby providing protection to the bacterial population. Here, we have used a novel approach of scr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70dd425846a028eb38242e9b211aeb0e
https://doi.org/10.1093/nar/gkt1419

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A widely conserved molecular switch controls quorum sensing and symbiosis island transfer inMesorhizobium lotithrough expression of a novel antiactivator

Autor: Victor M. Komarovsky, Joshua P. Ramsay, George P. C. Salmond, Michael F. Hynes, Ron L. Dy, John T. Sullivan, Anthony S. Major, Clive W. Ronson

Publikováno v: Molecular Microbiology. 87:1-13

Summary ICEMlSymR7A of Mesorhizobium loti is an integrative and conjugative element (ICE) that confers the ability to form a nitrogen-fixing symbiosis with Lotus species. Horizontal transfer is activated by TraR and N-acyl-homoserine lactone (AHL), w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55f3de15e92adccbd5663fb335778b3b
https://doi.org/10.1111/mmi.12079

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Gene regulation by engineered CRISPR-Cas systems

Autor: Ron L. Dy, Peter C. Fineran

Publikováno v: Current opinion in microbiology. 18

The clustered regularly interspaced short palindromic repeat (CRISPR) arrays and their CRISPR associated (Cas) proteins constitute adaptive immune systems in bacteria and archaea that provide protection from bacteriophages, plasmids and other mobile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3a97c44dffb25edcca9685e6bc3cb2
https://pubmed.ncbi.nlm.nih.gov/24637219

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Priming in the Type I-F CRISPR-Cas system triggers strand-independent spacer acquisition, bi-directionally from the primed protospacer

Autor: Rebecca E. McKenzie, James T. Chang, Peter C. Fineran, Corinda Taylor, Raymond H.J. Staals, Bridget N.J. Watson, Corinna Richter, Matthew B. McNeil, Ron L. Dy

Publikováno v: Nucleic acids research, 42(13), 8516-8526
Nucleic Acids Research
Nucleic acids research 42 (2014) 13

Clustered regularly interspaced short palindromic repeats (CRISPR), in combination with CRISPR associated (cas) genes, constitute CRISPR-Cas bacterial adaptive immune systems. To generate immunity, these systems acquire short sequences of nucleic aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50613ddf198b19e90cc87faf154f565c
https://research.wur.nl/en/publications/priming-in-the-type-i-f-crispr-cas-system-triggers-strand-indepen

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Cytotoxic Chromosomal Targeting by CRISPR/Cas Systems Can Reshape Bacterial Genomes and Expel or Remodel Pathogenicity Islands

Autor: James T. Chang, Ron L. Dy, Tamzin Gristwood, Peter C. Fineran, Corinda Taylor, Rita Przybilski, Reuben B. Vercoe, Andrew R. Pitman, Corinna Richter, James S. Clulow

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 9, Iss 4, p e1003454 (2013)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbadc9c881a4b8608b7c7f3479379703
http://europepmc.org/articles/PMC3630108

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A widely conserved molecular switch controls quorum sensing and symbiosis island transfer in Mesorhizobium loti through expression of a novel antiactivator

Autor: Joshua P, Ramsay, Anthony S, Major, Victor M, Komarovsky, John T, Sullivan, Ron L, Dy, Michael F, Hynes, George P C, Salmond, Clive W, Ronson

Publikováno v: Molecular microbiology. 87(1)

ICEMlSym(R7A) of Mesorhizobium loti is an integrative and conjugative element (ICE) that confers the ability to form a nitrogen-fixing symbiosis with Lotus species. Horizontal transfer is activated by TraR and N-acyl-homoserine lactone (AHL), which c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f22b40a3d8a9196c03391ff3724e9f7
https://pubmed.ncbi.nlm.nih.gov/23106190

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