Determination of in vitro immunotoxic potencies of a series of perfluoralkylsubstances (PFASs) in human Namalwa B lymphocyte and human Jurkat T lymphocyte cells

Autor: Aafke W. F. Janssen, Wendy Jansen Holleboom, Deborah Rijkers, Jochem Louisse, Sjoerdtje A. Hoekstra, Sanne Schild, Misha F. Vrolijk, Ron L. A. P. Hoogenboom, Karsten Beekmann

Publikováno v: Frontiers in Toxicology, Vol 6 (2024)

Exposure to PFASs is associated to several adverse health effects, such as immunotoxicity. Immunotoxic effects of PFOA and PFOS, including a reduced antibody response in both experimental animals and humans, have been reported. However, there is limi

Externí odkaz: https://doaj.org/article/1fdaed18e8dc44ae98f85dd2c4aeab56

A Strategy to Replace the Mouse Bioassay for Detecting and Identifying Lipophilic Marine Biotoxins by Combining the Neuro-2a Bioassay and LC-MS/MS Analysis

Autor: Marcia Bodero, Arjen Gerssen, Liza Portier, Mirjam D. Klijnstra, Ron L. A. P. Hoogenboom, Leonardo Guzmán, Peter J. M. Hendriksen, Toine F. H. Bovee

Publikováno v: Marine Drugs, Vol 16, Iss 12, p 501 (2018)

Marine biotoxins in fish and shellfish can cause several symptoms in consumers, such as diarrhea, amnesia, or even death by paralysis. Monitoring programs are in place for testing shellfish on a regular basis. In some countries testing is performed u

Externí odkaz: https://doaj.org/article/6856227e61354d71a775ef9d2d07e8e1

First Report on the Occurrence of Tetrodotoxins in Bivalve Mollusks in The Netherlands

Autor: Arjen Gerssen, Toine H. F. Bovee, Mirjam D. Klijnstra, Marnix Poelman, Liza Portier, Ron L. A. P. Hoogenboom

Publikováno v: Toxins, Vol 10, Iss 11, p 450 (2018)

Tetrodotoxin (TTX) is traditionally associated with seafood from tropical regions, but recently TTX was detected in bivalve mollusks in more temperate European waters. In The Netherlands it was therefore decided to monitor TTX in shellfish harvested

Externí odkaz: https://doaj.org/article/344c72fe06ad414d8d89f70fc31f525a

Perfluoroalkyl substances (PFASs) decrease the expression of recombination-activating genes (RAG1 and RAG2) in human B lymphoma Namalwa cells

Autor: Aafke W. F. Janssen, Jochem Louisse, Deborah Rijkers, Nicole E. T. Pinckaers, Sjoerdtje A. Hoekstra, Ron L. A. P. Hoogenboom, Ad A. C. M. Peijnenburg, Karsten Beekmann

Publikováno v: Archives of Toxicology, 97(2), 457-468
Archives of Toxicology 97 (2023) 2

Per- and polyfluoroalkyl substances (PFASs) are omnipresent and have been shown to induce a wide range of adverse effects, including hepatotoxicity, developmental toxicity and immunotoxicity. So far, little information is available about the mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732d892073b0709f703bf22dc744132d
https://doi.org/10.1007/s00204-022-03405-z

Identification of phosphodiesterase type-5 (PDE-5) inhibitors in herbal supplements using a tiered approach and associated consumer risk

Autor: Felicia Akuamoa, Toine F. H. Bovee, Ruud van Dam, Lilian Maro, Sebastiaan Wesseling, Jacques Vervoort, Ivonne M. C. M. Rietjens, Ron L. A. P. Hoogenboom

Publikováno v: Food Additives and Contaminants-Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 39 (2022) 6
Food Additives and Contaminants-Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, 39(6), 1021-1032

The use of herbal supplements for improved sexual performance is a common practice amongst the youth and some senior citizens in Ghana. These products are considered ‘natural’ and greatly preferred over synthetic alternatives due to the assurance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842ba26851e2d72a6000a5aebac9faf9
https://doi.org/10.1080/19440049.2022.2052972