Determination of in vitro immunotoxic potencies of a series of perfluoralkylsubstances (PFASs) in human Namalwa B lymphocyte and human Jurkat T lymphocyte cells

Autor: Aafke W. F. Janssen, Wendy Jansen Holleboom, Deborah Rijkers, Jochem Louisse, Sjoerdtje A. Hoekstra, Sanne Schild, Misha F. Vrolijk, Ron L. A. P. Hoogenboom, Karsten Beekmann

Publikováno v: Frontiers in Toxicology, Vol 6 (2024)

Exposure to PFASs is associated to several adverse health effects, such as immunotoxicity. Immunotoxic effects of PFOA and PFOS, including a reduced antibody response in both experimental animals and humans, have been reported. However, there is limi

Externí odkaz: https://doaj.org/article/1fdaed18e8dc44ae98f85dd2c4aeab56

Perfluoroalkyl substances (PFASs) decrease the expression of recombination-activating genes (RAG1 and RAG2) in human B lymphoma Namalwa cells

Autor: Aafke W. F. Janssen, Jochem Louisse, Deborah Rijkers, Nicole E. T. Pinckaers, Sjoerdtje A. Hoekstra, Ron L. A. P. Hoogenboom, Ad A. C. M. Peijnenburg, Karsten Beekmann

Publikováno v: Archives of Toxicology, 97(2), 457-468
Archives of Toxicology 97 (2023) 2

Per- and polyfluoroalkyl substances (PFASs) are omnipresent and have been shown to induce a wide range of adverse effects, including hepatotoxicity, developmental toxicity and immunotoxicity. So far, little information is available about the mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732d892073b0709f703bf22dc744132d
https://doi.org/10.1007/s00204-022-03405-z

Identification of phosphodiesterase type-5 (PDE-5) inhibitors in herbal supplements using a tiered approach and associated consumer risk

Autor: Felicia Akuamoa, Toine F. H. Bovee, Ruud van Dam, Lilian Maro, Sebastiaan Wesseling, Jacques Vervoort, Ivonne M. C. M. Rietjens, Ron L. A. P. Hoogenboom

Publikováno v: Food Additives and Contaminants-Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 39 (2022) 6
Food Additives and Contaminants-Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, 39(6), 1021-1032

The use of herbal supplements for improved sexual performance is a common practice amongst the youth and some senior citizens in Ghana. These products are considered ‘natural’ and greatly preferred over synthetic alternatives due to the assurance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842ba26851e2d72a6000a5aebac9faf9
https://doi.org/10.1080/19440049.2022.2052972

Current Insights into Monitoring, Bioaccumulation, and Potential Health Effects of Microplastics Present in the Food Chain

Autor: Leonard W. D. van Raamsdonk, Meike van der Zande, Albert A. Koelmans, Ron L. A. P. Hoogenboom, Ruud J. B. Peters, Maria J. Groot, Ad A. C. M. Peijnenburg, Yannick J. A. Weesepoel

Publikováno v: Foods, Vol 9, Iss 1, p 72 (2020)

Microplastics (MPs) are considered an emerging issue as environmental pollutants and a potential health threat. This review will focus on recently published data on concentrations in food, possible effects, and monitoring methods. Some data are avail

Externí odkaz: https://doaj.org/article/17d9450692034c0f9a7e9510ac17ed69

The Need and Potential of Biosensors to Detect Dioxins and Dioxin-Like Polychlorinated Biphenyls along the Milk, Eggs and Meat Food Chain

Autor: Aize Kijlstra, Bastiaan G. Meerburg, Willem Haasnoot, Ron L. A. P. Hoogenboom, Imke J. M. De Boer, Jeerasak Chobtang

Publikováno v: Sensors, Vol 11, Iss 12, Pp 11692-11716 (2011)

Dioxins and dioxin-like polychlorinated biphenyls (DL-PCBs) are hazardous toxic, ubiquitous and persistent chemical compounds, which can enter the food chain and accumulate up to higher trophic levels. Their determination requires sophisticated metho

Externí odkaz: https://doaj.org/article/7cbb48b594314c11987fec3171f1cf9e