Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Ron Korstanje"'
Autor:
Hope Dang, Raul Castro-Portuguez, Luis Espejo, Grant Backer, Samuel Freitas, Erica Spence, Jeremy Meyers, Karissa Shuck, Emily A. Gardea, Leah M. Chang, Jonah Balsa, Niall Thorns, Caroline Corban, Teresa Liu, Shannon Bean, Susan Sheehan, Ron Korstanje, George L. Sutphin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Tryptophan metabolism through the kynurenine pathway influences molecular processes critical to healthy aging including immune signaling, redox homeostasis, and energy production. Aberrant kynurenine metabolism occurs during normal aging and
Externí odkaz:
https://doaj.org/article/d818b49f9ce9488ab1b9a7b0ec1eae58
Autor:
Callan O'Connor, Gregory R Keele, Whitney Martin, Timothy Stodola, Daniel Gatti, Brian R Hoffman, Ron Korstanje, Gary A Churchill, Laura G Reinholdt
Publikováno v:
PLoS Genetics, Vol 20, Iss 4, p e1011248 (2024)
The health risks that arise from environmental exposures vary widely within and across human populations, and these differences are largely determined by genetic variation and gene-by-environment (gene-environment) interactions. However, risk assessm
Externí odkaz:
https://doaj.org/article/8001d05cf09240178e416101081e5df1
Autor:
Bradford T. Hull, Kayla M. Miller, Caroline Corban, Grant Backer, Susan Sheehan, Ron Korstanje, George L. Sutphin
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 599 (2024)
Age is the primary risk factor for neurodegenerative diseases such as Alzheimer’s and Huntington’s disease. Alzheimer’s disease is the most common form of dementia and a leading cause of death in the elderly population of the United States. No
Externí odkaz:
https://doaj.org/article/bef735e36d3c4f668da9249f8e418de8
Autor:
Courtney Willey, Ron Korstanje
Publikováno v:
Frontiers in Zoology, Vol 19, Iss 1, Pp 1-8 (2022)
Abstract Unique genetic adaptations are present in bears of every species across the world. From (nearly) shutting down important organs during hibernation to preventing harm from lifestyles that could easily cause metabolic diseases in humans, bears
Externí odkaz:
https://doaj.org/article/5bc57c362ac14b79905223092414069e
Autor:
Gregory R. Keele, Ji-Gang Zhang, John Szpyt, Ron Korstanje, Steven P. Gygi, Gary A. Churchill, Devin K. Schweppe
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112715- (2023)
Summary: Maintenance of protein homeostasis degrades with age, contributing to aging-related decline and disease. Previous studies have primarily surveyed transcriptional aging changes. To define the effects of age directly at the protein level, we p
Externí odkaz:
https://doaj.org/article/0ebf66b87b984c858446f29df12b141a
Publikováno v:
Laboratory Animal Research, Vol 38, Iss 1, Pp 1-9 (2022)
Abstract Background The convertase subtilisin/kexin family 1 gene (PCSK1) has been associated in various human genetics studies with a wide spectrum of metabolic phenotypes, including early-onset obesity, hyperphagia, diabetes insipidus, and others.
Externí odkaz:
https://doaj.org/article/6a5a63445e254868ad0f842a73009920
Autor:
Yuka Takemon, Joel M Chick, Isabela Gerdes Gyuricza, Daniel A Skelly, Olivier Devuyst, Steven P Gygi, Gary A Churchill, Ron Korstanje
Publikováno v:
eLife, Vol 10 (2021)
Little is known about the molecular changes that take place in the kidney during the aging process. In order to better understand these changes, we measured mRNA and protein levels in genetically diverse mice at different ages. We observed distinctiv
Externí odkaz:
https://doaj.org/article/890b27ddf1e64386900475149093834c
Autor:
Chieh Ming Liao, Vera Christine Wulfmeyer, Maxine Swallow, Christine Susanne Falk, Hermann Haller, Ron Korstanje, Anette Melk, Roland Schmitt
Publikováno v:
Cells, Vol 10, Iss 6, p 1437 (2021)
Cellular senescence, a stress-induced state of irreversible cell cycle arrest, is associated with organ dysfunction and age-related disease. While immortalized cell lines bypass key pathways of senescence, important mechanisms of cellular senescence
Externí odkaz:
https://doaj.org/article/fd4eb7fb10fd46b6a50570d67f87253f
Autor:
Jason A Bubier, George L Sutphin, Timothy J Reynolds, Ron Korstanje, Axis Fuksman-Kumpa, Erich J Baker, Michael A Langston, Elissa J Chesler
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214523 (2019)
Understanding the biological mechanisms behind aging, lifespan and healthspan is becoming increasingly important as the proportion of the world's population over the age of 65 grows, along with the cost and complexity of their care. BigData oriented
Externí odkaz:
https://doaj.org/article/5a79fd5028db45588e00dc965f82eab9
Autor:
Theun de Groot, Lars Damen, Leanne Kosse, Mohammad Alsady, Rosalinda Doty, Ruben Baumgarten, Susan Sheehan, Johan van der Vlag, Ron Korstanje, Peter M T Deen
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189485 (2017)
Glycogen synthase kinase 3 (GSK3) plays an important role in the development of diabetes mellitus and renal injury. GSK3 inhibition increases glucose uptake in insulin-insensitive muscle and adipose tissue, while it reduces albuminuria and glomerulos
Externí odkaz:
https://doaj.org/article/fc0e4e661fe24763ab22800ae06b1802