Alternative computational protocols for supercharging protein surfaces for reversible unfolding and retention of stability.

Autor: Bryan S Der, Christien Kluwe, Aleksandr E Miklos, Ron Jacak, Sergey Lyskov, Jeffrey J Gray, George Georgiou, Andrew D Ellington, Brian Kuhlman

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e64363 (2013)

Reengineering protein surfaces to exhibit high net charge, referred to as "supercharging", can improve reversibility of unfolding by preventing aggregation of partially unfolded states. Incorporation of charged side chains should be optimized while c

Externí odkaz: https://doaj.org/article/b678fc5e8c334b6b916ec9554493b6f6

Improving physical distancing among healthcare workers in a pediatric intensive care unit

Autor: Anna C, Sick-Samuels, Sara, Cosgrove, Clare, Rock, Alejandra, Salinas, Opeyemi, Oladapo-Shittu, Ayse P, Gurses, Briana, Vecchio-Pagan, Patience, Osei, Yea-Jen, Hsu, Ron, Jacak, Kristina K, Zudock, Kianna M, Blount, Kenneth V, Bowden, Sara, Keller

Publikováno v: Infection Control and Hospital Epidemiology

Background:Healthcare workers (HCWs) not adhering to physical distancing recommendations is a risk factor for acquisition of severe acute respiratory coronavirus virus 2 (SARS-CoV-2). The study objective was to assess the impact of interventions to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f9acc8d31ee4cb951227423c38af24
https://pubmed.ncbi.nlm.nih.gov/34903308

Viruses at Solid-Water Interfaces: A Systematic Assessment of Interactions Driving Adsorption

Autor: Michael Sander, Antonius Armanious, Meret Aeppli, Tamar Kohn, Therese Sigstam, Ron Jacak, Dominik Refardt

Publikováno v: Environmental sciencetechnology. 50(2)

Adsorption to solid-water interfaces is a major process governing the fate of waterborne viruses in natural and engineered systems. The relative contributions of different interaction forces to adsorption and their dependence on the physicochemical p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82be5591909fba40124146835b65de20
https://pubmed.ncbi.nlm.nih.gov/26636722

A structural bioinformatics approach for identifying proteins predisposed to bind linear epitopes on pre-selected target proteins

Autor: Ron Jacak, Eun Jung Choi, Brian Kuhlman

We have developed a protocol for identifying proteins that are predisposed to bind linear epitopes on target proteins of interest. The protocol searches through the protein database for proteins (scaffolds) that are bound to peptides with sequences s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6a6a813edbbfb0e25a7ee61b2c1121

Community-Wide Assessment of Protein-Interface Modeling Suggests Improvements to Design Methodology

Autor: Libin Cao, Anne Poupon, Brian G. Pierce, Howook Hwang, Ying Chen, Victor L. Hsu, Hasup Lee, Yangyu Huang, Daisuke Kihara, Juan Fernández-Recio, Vladimir Potapov, Aroop Sircar, Chaok Seok, Timothy A. Whitehead, Jérôme Azé, Nir Ben Tal, Seren Soner, Brian Kuhlman, P. Benjamin Stranges, Nobuyuki Uchikoga, Sanbo Qin, Xinqi Gong, Yi Xiao, Carlos J. Camacho, Yaoqi Zhou, Gideon Schreiber, Ora Schueler-Furman, Paul A. Bates, Krishna Praneeth Kilambi, Joël Janin, Mati Cohen, Julie C. Mitchell, Panwen Wang, Cunxin Wang, Raed Khashan, Mayuko Takeda-Shitaka, Lin Li, Martin Zacharias, Alexander Tropsha, Genki Terashi, Xiaofan Li, David Baker, Jian Zhan, Julie Bernauer, Zohar Itzhaki, Mainak Guharoy, Eva-Maria Strauch, Xiaoqin Zou, Thom Vreven, Hahnbeom Park, Sheng-You Huang, Stephen Bush, Daron M. Standley, Feng Yang, Yuko Tsuchiya, Fan Jiang, Jacob E. Corn, Takashi Ishida, Chunhua Li, Junsu Ko, Robert G. Hall, Thomas Bourquard, Iain H. Moal, Weiyi Zhang, C.M. Driggers, Nir London, Jessica L. Morgan, Ron Jacak, Haruki Nakamura, Laura Pérez-Cano, Denis Fouches, Bin Liu, Yutaka Akiyama, Omar N. A. Demerdash, Yuval Inbar, Xianjin Xu, Yuedong Yang, Dachuan Guo, Masahito Ohue, Turkan Haliloglu, Jeffrey J. Gray, Juan Esquivel-Rodríguez, Alexandre M. J. J. Bonvin, Pemra Ozbek, Sarel J. Fleishman, Şefik Kerem Ovali, Charles H. Robert, Huan-Xiang Zhou, Eiji Kanamori, Yuri Matsuzaki, Carles Pons, Zhiping Weng, Kengo Kinoshita, Shoshana J. Wodak, Shiyong Liu, Panagiotis L. Kastritis

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2011, 414 (2), in press. ⟨10.1016/j.jmb.2011.09.031⟩
Journal of Molecular Biology, Elsevier, 2011, in press. ⟨10.1016/j.jmb.2011.09.031⟩
Journal of Molecular Biology, 2011, 414 (2), in press. ⟨10.1016/j.jmb.2011.09.031⟩
Journal of Molecular Biology, 414(2), 289. Academic Press Inc.

International audience; The CAPRI (Critical Assessment of Predicted Interactions) and CASP (Critical Assessment of protein Structure Prediction) experiments have demonstrated the power of community-wide tests of methodology in assessing the current s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc9fe98b9e40ef44a6829a3e83984a1
https://hal.inria.fr/inria-00637848