Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Ron J, Bouchard"'
Publikováno v:
Neurobiology of Disease, Vol 144, Iss , Pp 105023- (2020)
Externí odkaz:
https://doaj.org/article/e313d125b308492b92a755494ac2f0d7
Publikováno v:
Neurobiology of Disease, Vol 136, Iss , Pp 104743- (2020)
Rho GTPases play a central role in neuronal survival; however, the antagonistic relationship between Rac and Rho in the regulation of motor neuron survival remains poorly defined. In the current study, we demonstrate that treatment with NSC23766, a s
Externí odkaz:
https://doaj.org/article/164c1d9f09b04e759dd92dc0dee22349
Autor:
Nathan Duval, Whitney A. Sumner, Anna G. Andrianakos, Josie J. Gray, Ron J. Bouchard, Heather M. Wilkins, Daniel A. Linseman
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
The molecular mechanisms leading to motor neuron death in amyotrophic lateral sclerosis (ALS) are unknown; however, several studies have provided evidence of a central role for intrinsic apoptosis. Bcl-2 homology-3 domain (BH3)-only proteins are pro-
Externí odkaz:
https://doaj.org/article/eaa9ca77aebf44828307083c019709c8
Publikováno v:
Data in Brief
Data in Brief, Vol 6, Iss, Pp 998-1006 (2016)
Data in Brief, Vol 6, Iss, Pp 998-1006 (2016)
The data included in this article comprise raw and processed images of fixed cells at baseline and subjected to various experimental perturbations. This dataset includes images of HUVEC cells fixed and subsequently incubated at either 37°C or room t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee81326ecff206d51ec3830f2e4e6f0
Publikováno v:
Journal of Neurochemistry. 136:918-930
Communications between neurons and glial cells play an important role in regulating homeostasis in the central nervous system. cAMP response element-binding protein (CREB), a transcription factor, is down-regulated by neurotoxins, which are known to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45be216091ddff909cdd723bd57ab518
https://doi.org/10.1111/jnc.13497
https://doi.org/10.1111/jnc.13497
Publikováno v:
Neurobiol Dis
Neurobiology of Disease, Vol 136, Iss, Pp 104743-(2020)
Neurobiology of Disease, Vol 136, Iss, Pp 104743-(2020)
Rho GTPases play a central role in neuronal survival; however, the antagonistic relationship between Rac and Rho in the regulation of motor neuron survival remains poorly defined. In the current study, we demonstrate that treatment with NSC23766, a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5352019152ef1a4743e38e0ca8e016e9
https://doi.org/10.1016/j.nbd.2020.104743
https://doi.org/10.1016/j.nbd.2020.104743
Autor:
Klaus Aktories, Ron J. Bouchard, Sai Anandi Ramaswami, Trisha R. Stankiewicz, Daniel A. Linseman
Publikováno v:
Journal of Biological Chemistry. 290:9363-9376
Background: Rac GTPase is essential for the survival of primary cerebellar granule neurons (CGNs). Results: NSC23766-mediated Rac inhibition induces CGN apoptosis through deactivation of prosurvival MEK5/ERK5 signaling. Conclusion: Targeted inhibitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::decd525ca9dab4c09cb5046002651cff
https://doi.org/10.1074/jbc.m114.575217
https://doi.org/10.1074/jbc.m114.575217
Autor:
Nathan Duval, Josie J. Gray, Ron J. Bouchard, Heather M. Wilkins, Anna G. Andrianakos, Daniel A. Linseman, Whitney A. Sumner
Publikováno v:
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Frontiers in Cellular Neuroscience, Vol 12 (2018)
The molecular mechanisms leading to motor neuron death in amyotrophic lateral sclerosis (ALS) are unknown; however, several studies have provided evidence of a central role for intrinsic apoptosis. Bcl-2 homology-3 domain (BH3)-only proteins are pro-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862668646ff2e1c7bb66282cf509535e
https://pubmed.ncbi.nlm.nih.gov/29440992
https://pubmed.ncbi.nlm.nih.gov/29440992
Autor:
Guey Chuen Perng, Ron J. Bouchard, Benedikt B. Kaufer, Jane E.B. Reusch, P. Mason McClatchey, Aamir Shahzad, Nicholas L. Baird, Peter G. E. Kennedy, Donald H. Gilden, Jacqueline L. Bowlin, Randall J. Cohrs, Amy C. Keller, Hussain Badani
Publikováno v:
Journal of neurovirology. 22(5)
Varicella zoster virus (VZV) is a ubiquitous alphaherpesvirus that establishes latency in ganglionic neurons throughout the neuraxis after primary infection. Here, we show that VZV infection induces a time-dependent significant change in mitochondria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491042afad22a24379fb1559f2f6c18d
https://pubmed.ncbi.nlm.nih.gov/27245593
https://pubmed.ncbi.nlm.nih.gov/27245593
Publikováno v:
Journal of Neurochemistry. 123:919-931
Glucagon-like peptide-1 (GLP-1)-based therapies are currently available for the treatment of type 2 diabetes, based on their actions on pancreatic β cells. GLP-1 is also known to exert neuroprotective actions. To determine its mechanism of action, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00df25c2b56c042ed241f73e57dc60ec
https://doi.org/10.1111/jnc.12036
https://doi.org/10.1111/jnc.12036