Výsledky vyhledávání - "Ron G. RosenfeLd"

Review

The IGF System: Molecular Biology, Physiology, and Clinical Applications Ron G. Rosenfeld Charles T. Roberts, Jr.

Autor: Baumrucker, Craig R.

Publikováno v: The Quarterly Review of Biology, 2000 Jun 01. 75(2), 225-226.

Externí odkaz: https://www.jstor.org/stable/2664366

Akademický článek

Screening a large pediatric cohort with GH deficiency for mutations in genes regulating pituitary development and GH secretion: Frequencies, phenotypes and growth outcomesResearch in context

Autor: Werner F. Blum, Jürgen Klammt, Serge Amselem, Heike M. Pfäffle, Marie Legendre, Marie-Laure Sobrier, Marie-Pierre Luton, Christopher J. Child, Christine Jones, Alan G. Zimmermann, Charmian A. Quigley, Gordon B. Cutler, Jr, Cheri L. Deal, Jan Lebl, Ron G. Rosenfeld, John S. Parks, Roland W. Pfäffle

Publikováno v: EBioMedicine, Vol 36, Iss , Pp 390-400 (2018)

Background: Pituitary development and GH secretion are orchestrated by multiple genes including GH1, GHRHR, GLI2, HESX1, LHX3, LHX4, PROP1, POU1F1, and SOX3. We aimed to assess their mutation frequency and clinical relevance in children with severe G

Externí odkaz: https://doaj.org/article/eb38d45a2af84fb1a420e9f01ae4ca4c

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Akademický článek

Dominant-negative STAT5B mutations cause growth hormone insensitivity with short stature and mild immune dysregulation

Autor: Jürgen Klammt, David Neumann, Evelien F. Gevers, Shayne F. Andrew, I. David Schwartz, Denise Rockstroh, Roberto Colombo, Marco A. Sanchez, Doris Vokurkova, Julia Kowalczyk, Louise A. Metherell, Ron G. Rosenfeld, Roland Pfäffle, Mehul T. Dattani, Andrew Dauber, Vivian Hwa

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Severe growth hormone insensitivity syndrome (GHIS) with immunodeficiency is caused by autosomal recessive mutations in STAT5B. Here the authors report heterozygous STAT5B mutations with dominant-negative effects, causing mild GHIS without immune def

Externí odkaz: https://doaj.org/article/2f6935ea40d3432bb5ef0a1b2cc1c995

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Akademický článek

Pregnancy-Associated Plasma Protein (PAPP)-A2 in Physiology and Disease

Autor: Vicente Barrios, Julie A. Chowen, Álvaro Martín-Rivada, Santiago Guerra-Cantera, Jesús Pozo, Shoshana Yakar, Ron G. Rosenfeld, Luis A. Pérez-Jurado, Juan Suárez, Jesús Argente

Publikováno v: Cells, Vol 10, Iss 12, p 3576 (2021)

The growth hormone (GH)/insulin-like growth factor (IGF) axis plays fundamental roles during development, maturation, and aging. Members of this axis, composed of various ligands, receptors, and binding proteins, are regulated in a tissue- and time-s

Externí odkaz: https://doaj.org/article/7137f6b70c424230a9041cc9a0718ec4

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Akademický článek

Mutations in pregnancy‐associated plasma protein A2 cause short stature due to low IGF‐I availability

Publikováno v: EMBO Molecular Medicine, Vol 8, Iss 4, Pp 363-374 (2016)

Abstract Mutations in multiple genes of the growth hormone/IGF‐I axis have been identified in syndromes marked by growth failure. However, no pathogenic human mutations have been reported in the six high‐affinity IGF‐binding proteins (IGFBPs) o

Externí odkaz: https://doaj.org/article/224828b64cec4bdd98548afe1c5d47d5

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Efficacy and Safety of Once-Weekly Somatrogon Compared with Once-Daily Somatropin (Genotropin®) in Japanese Children with Pediatric Growth Hormone Deficiency: Results from a Randomized Phase 3 Study

Autor: Reiko Horikawa, Toshiaki Tanaka, Yukihiro Hasegawa, Tohru Yorifuji, David Ng, Ron G. Rosenfeld, Yuko Hoshino, Akifumi Okayama, Daisuke Shima, Roy Gomez, Aleksandra Pastrak, Orlando Castellanos

Publikováno v: Hormone Research in Paediatrics. 95:275-285

Introduction: Somatrogon is a long-acting recombinant human growth hormone being developed as a once-weekly treatment for children with growth hormone deficiency (GHD). The objective of this phase 3 study (NCT03874013) was to compare the efficacy and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82b58ad5fa34116be688bc1aac26447
https://doi.org/10.1159/000524600

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The History of the Insulin-Like Growth Factor System

Autor: Bradley S. Miller, Alan D. Rogol, Ron G. Rosenfeld

Publikováno v: Hormone research in paediatrics. 95(6)

The growth hormone (GH)–insulin-like growth factor (IGF) cascade is central to the regulation of growth and metabolism. This article focuses on the history of the components of the IGF system, with an emphasis on the peptide hormones, IGF-I and -II

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a33254331c52aad3c20dd988e4529f7
https://pubmed.ncbi.nlm.nih.gov/36446332

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