Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Ron E. Savage"'
Autor:
Ron E. Savage, Ian W. Flinn, John C. Byrd, Farrukh T. Awan, Sudharshan Eathiraj, Deborah M. Stephens, Lyndsey A. Szuszkiewicz, Kate Tith, Sean D. Reiff, Kerry A. Rogers, Jennifer A. Woyach
Publikováno v:
Blood. 132:3136-3136
Background: Aberrant activation of B-cell receptor (BCR) signaling is considered to be a major oncogenic mechanism that leads to the development and progression of multiple B-cell malignancies. ARQ 531 is a reversible ATP competitive inhibitor of BTK
Autor:
Chang-Rung Chen, Jean-Marc Lapierre, Jeffrey D. Szwaya, Yanbin Liu, Nivedita Namdev, Deirdre Lowe, Ron E. Savage, Cathy O. Bull, Thomas C K Chan, Mark A. Ashwell, Dennis S. France
Publikováno v:
Cancer Research. 70:4501-4501
An activating somatic mutation in BRAF kinase (V600E) is found in approximately 70% of melanomas, 50% of papillary thyroid cancers and 10% of colon cancers, fueling interest in BRAF (V600E) as a therapeutic target for cancer treatment. We have previo