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pro vyhledávání: '"Ron Des Jong"'
Autor:
Saul H. Rosenberg, Tongmei Li, Gui-Dong Zhu, Keith W. Woods, Jason N. Abrams, Jürgen Dinges, Eric F. Johnson, Tilman Oltersdorf, Clarissa G. Jakob, Qun Li, John E. Fisher, Xuesong Liu, Vincent S. Stoll, Garrick Packard, Ron Des Jong, Sheela A. Thomas, Vincent L. Giranda, Xiaohong Song, Yan Luo, Vered Klinghofer, Jianchun Gong, Yan Shi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2000-2007
Structure-based design and synthesis of the 3,4'-bispyridinylethylene series led to the discovery of 3-isoquinolinylpyridine 13a as a potent PKB/Akt inhibitor with an IC(50) of 1.3nM against Akt1. Compound 13a shows excellent selectivity against dist